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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 557

FusionGeneSummary for ACTG1_RPS5

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTG1_RPS5
Fusion gene ID: 557
HgeneTgene
Gene symbol

ACTG1

RPS5

Gene ID

71

6193

Gene nameactin gamma 1ribosomal protein S5
SynonymsACT|ACTG|DFNA20|DFNA26|HEL-176S5
Cytomap

17q25.3

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionactin, cytoplasmic 2cytoskeletal gamma-actinepididymis luminal protein 17640S ribosomal protein S5small ribosomal subunit protein uS7
Modification date2018052220180523
UniProtAcc

P63261

P46782

Ensembl transtripts involved in fusion geneENST00000331925, ENST00000573283, 
ENST00000575842, ENST00000575087, 
ENST00000601521, ENST00000598098, 
ENST00000598495, ENST00000196551, 
ENST00000596046, 
Fusion gene scores* DoF score25 X 19 X 11=52256 X 6 X 2=72
# samples 346
** MAII scorelog2(34/5225*10)=-3.94182438571791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTG1 [Title/Abstract] AND RPS5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ227834ACTG1chr17

79477287

+RPS5chr19

58898661

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000331925ENST00000601521ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000331925ENST00000598098ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000331925ENST00000598495ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000331925ENST00000196551ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000331925ENST00000596046ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000573283ENST00000601521ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000573283ENST00000598098ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000573283ENST00000598495ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000573283ENST00000196551ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000573283ENST00000596046ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575842ENST00000601521ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575842ENST00000598098ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575842ENST00000598495ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575842ENST00000196551ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575842ENST00000596046ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575087ENST00000601521ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575087ENST00000598098ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575087ENST00000598495ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575087ENST00000196551ACTG1chr17

79477287

+RPS5chr19

58898661

+
intron-5UTRENST00000575087ENST00000596046ACTG1chr17

79477287

+RPS5chr19

58898661

+

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FusionProtFeatures for ACTG1_RPS5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTG1

P63261

RPS5

P46782

Actins are highly conserved proteins that are involvedin various types of cell motility and are ubiquitously expressedin all eukaryotic cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACTG1_RPS5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACTG1_RPS5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTG1_RPS5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneACTG1P63261DB11638ArtenimolActin, cytoplasmic 2small moleculeapproved|investigational
TgeneRPS5P46782DB11638Artenimol40S ribosomal protein S5small moleculeapproved|investigational

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RelatedDiseases for ACTG1_RPS5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTG1C1858172Deafness, Autosomal Dominant 205CTD_human;UNIPROT
HgeneACTG1C0007621Neoplastic Cell Transformation1CTD_human
HgeneACTG1C0009363Congenital ocular coloboma (disorder)1CTD_human
HgeneACTG1C0024667Animal Mammary Neoplasms1CTD_human
HgeneACTG1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneACTG1C0029456Osteoporosis1CTD_human
HgeneACTG1C0376634Craniofacial Abnormalities1CTD_human
HgeneACTG1C0497552Congenital neurologic anomalies1CTD_human
HgeneACTG1C0948089Acute Coronary Syndrome1CTD_human
HgeneACTG1C3281235BARAITSER-WINTER SYNDROME 21UNIPROT