FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5556

FusionGeneSummary for CASC15_CAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: CASC15_CAP2
Fusion gene ID: 5556
HgeneTgene
Gene symbol

CASC15

CAP2

Gene ID

401237

10486

Gene namecancer susceptibility 15cyclase associated actin cytoskeleton regulatory protein 2
SynonymsCANT|LINC00340|lnc-SOX4-1-
Cytomap

6p22.3

6p22.3

Type of genencRNAprotein-coding
Descriptioncancer susceptibility 15 (non-protein coding)cancer susceptibility candidate 15 (non-protein coding)long intergenic non-protein coding RNA 340adenylyl cyclase-associated protein 22810452G09RikCAP 2CAP, adenylate cyclase-associated protein, 2
Modification date2018051720180524
UniProtAcc

P40123

Ensembl transtripts involved in fusion geneENST00000605917, ENST00000229922, 
ENST00000489374, ENST00000378990, 
ENST00000493172, ENST00000465994, 
Fusion gene scores* DoF score7 X 5 X 4=1406 X 4 X 4=96
# samples 76
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CASC15 [Title/Abstract] AND CAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-85-A4CL-01ACASC15chr6

22020771

+CAP2chr6

17463227

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000605917ENST00000229922CASC15chr6

22020771

+CAP2chr6

17463227

+
intron-3CDSENST00000605917ENST00000489374CASC15chr6

22020771

+CAP2chr6

17463227

+
intron-intronENST00000605917ENST00000378990CASC15chr6

22020771

+CAP2chr6

17463227

+
intron-intronENST00000605917ENST00000493172CASC15chr6

22020771

+CAP2chr6

17463227

+
intron-intronENST00000605917ENST00000465994CASC15chr6

22020771

+CAP2chr6

17463227

+

Top

FusionProtFeatures for CASC15_CAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASC15

CAP2

P40123

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. May have a regulatory bifunctional role.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CASC15_CAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CASC15_CAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CASC15CAP2CAP1, ACTG1, YWHAE, PRPF40A, ARHGEF1, CSNK2A2, MCM4, NCKAP1, ACTB, CFL2, CAP2, MT1P3, EGFR, CFL1, MED4, MED23, POTEI, TWF2, BCL7A, BCL7C, ACTA2, ACTBL2, STYX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CASC15_CAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CASC15_CAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource