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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5548

FusionGeneSummary for CARM1_ZBTB32

check button Fusion gene summary
Fusion gene informationFusion gene name: CARM1_ZBTB32
Fusion gene ID: 5548
HgeneTgene
Gene symbol

CARM1

ZBTB32

Gene ID

10498

27033

Gene namecoactivator associated arginine methyltransferase 1zinc finger and BTB domain containing 32
SynonymsPRMT4FAXF|FAZF|Rog|TZFP|ZNF538
Cytomap

19p13.2

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionhistone-arginine methyltransferase CARM1protein arginine N-methyltransferase 4zinc finger and BTB domain-containing protein 32FANCC-interacting proteinfanconi anemia zinc finger proteinrepressor of GATAtestis zinc finger proteinzinc finger protein 538
Modification date2018052720180522
UniProtAcc

Q86X55

Q9Y2Y4

Ensembl transtripts involved in fusion geneENST00000327064, ENST00000344150, 
ENST00000392197, ENST00000442282, 
ENST00000262630, 
Fusion gene scores* DoF score9 X 5 X 9=4052 X 2 X 2=8
# samples 112
** MAII scorelog2(11/405*10)=-1.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: CARM1 [Title/Abstract] AND ZBTB32 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCARM1

GO:0016571

histone methylation

19405910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-B5-A5OE-01ACARM1chr19

10982598

+ZBTB32chr19

36206659

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000327064ENST00000392197CARM1chr19

10982598

+ZBTB32chr19

36206659

+
5CDS-intronENST00000327064ENST00000442282CARM1chr19

10982598

+ZBTB32chr19

36206659

+
5CDS-intronENST00000327064ENST00000262630CARM1chr19

10982598

+ZBTB32chr19

36206659

+
Frame-shiftENST00000344150ENST00000392197CARM1chr19

10982598

+ZBTB32chr19

36206659

+
5CDS-intronENST00000344150ENST00000442282CARM1chr19

10982598

+ZBTB32chr19

36206659

+
5CDS-intronENST00000344150ENST00000262630CARM1chr19

10982598

+ZBTB32chr19

36206659

+

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FusionProtFeatures for CARM1_ZBTB32


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CARM1

Q86X55

ZBTB32

Q9Y2Y4

Methylates (mono- and asymmetric dimethylation) theguanidino nitrogens of arginyl residues in several proteinsinvolved in DNA packaging, transcription regulation, pre-mRNAsplicing, and mRNA stability. Recruited to promoters upon geneactivation together with histone acetyltransferases fromEP300/P300 and p160 families, methylates histone H3 at 'Arg-17'(H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a),leading to activate transcription via chromatin remodeling. Duringnuclear hormone receptor activation and TCF7L2/TCF4 activation,acts synergically with EP300/P300 and either one of the p160histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTRor CTNNB1/beta-catenin to activate transcription. During myogenictranscriptional activation, acts together with NCOA3/ACTR as acoactivator for MEF2C. During monocyte inflammatory stimulation,acts together with EP300/P300 as a coactivator for NF-kappa-B.Acts as coactivator for PPARG, promotes adipocyte differentiationand the accumulation of brown fat tissue. Plays a role in theregulation of pre-mRNA alternative splicing by methylation ofsplicing factors. Also seems to be involved in p53/TP53transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at'Arg-580' and 'Arg-604' in the KIX domain, which impairs itsinteraction with CREB and inhibits CREB-dependent transcriptionalactivation. Also methylates arginine residues in RNA-bindingproteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.{ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:19405910}. DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptionaltransactivator and transcriptional repressor. Probably exerts itsrepressor effect by preventing GATA3 from binding to DNA. May playa role in regulating the differentiation and activation of helperT-cells (By similarity). {ECO:0000250,ECO:0000269|PubMed:10572087}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CARM1_ZBTB32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CARM1_ZBTB32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CARM1TP53, PRMT1, PABPN1, MEF2D, MYOD1, MYOG, NRIP1, NCOA3, CREBBP, HIST1H3A, EP300, NCOA2, RELA, SRCAP, CREB1, FOS, NCOA1, GRIP1, CTNNB1, MYC, STAT5A, PARP1, NR1H4, ARID1A, SMARCA4, SMARCC2, SMARCC1, NFKB1, SMARCE1, SMARCB1, ACTB, SMARCD1, H3F3A, CEBPB, TERF2, WDR5, AXIN1, AFF1, IRF4, ELAVL1, CUL3, CUL5, CUL2, CUL1, COPS5, CAND1, RABGAP1, TP63, METTL21C, HNRNPA1, DNAJA3, NUDT21, QKI, DAXX, MALT1, PYGO1, SPAG8, UBE2I, FAF1, SUPT5H, HSPH1, ILK, PARVA, PPAT, UGP2, XPO7, DROSHA, TNRC6B, CACYBP, NUDCD3, KAT2B, KIAA1191, NECAP2, HEY2, CNN3, FOSL2, TICAM1, IL36A, TEX33, FASN, HNRNPK, PXDNL, SNRPC, CTBP1, NTRK1, KRAS, IFI16, DZIP3, MTMR14, MTMR6, MTMR8, HRSP12, CEP170B, KIAA1683, ALDOA, GTSE1, SH3BP5L, KIF16B, MED9, RBM4, HN1L, ETV4, WDR4, ARFGAP1, PRCC, DGCR14, C1orf94, RAB39B, RAB11A, ATP6V1G1, VASN, BRCA1, ESR1ZBTB32TXNIP, RHOXF2, FANCC, GATA2, ZBTB16, ELF2, HOXD4, ZNF490, ATXN1, ERVK-6, AR, MVP, PITX1, PRKAB2, FMOD, DAB1, MLX, RBPMS, PRDM1, C6orf165


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CARM1_ZBTB32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CARM1_ZBTB32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCARM1C0033860Psoriasis1CTD_human