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Fusion gene ID: 5546 |
FusionGeneSummary for CARM1_PLA2G4C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CARM1_PLA2G4C | Fusion gene ID: 5546 | Hgene | Tgene | Gene symbol | CARM1 | PLA2G4C | Gene ID | 10498 | 8605 |
| Gene name | coactivator associated arginine methyltransferase 1 | phospholipase A2 group IVC | |
| Synonyms | PRMT4 | CPLA2-gamma | |
| Cytomap | 19p13.2 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-arginine methyltransferase CARM1protein arginine N-methyltransferase 4 | cytosolic phospholipase A2 gammaphospholipase A2, group IVC (cytosolic, calcium-independent) | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q86X55 | Q9UP65 | |
| Ensembl transtripts involved in fusion gene | ENST00000327064, ENST00000344150, | ENST00000599111, ENST00000354276, ENST00000413144, ENST00000599921, ENST00000596510, | |
| Fusion gene scores | * DoF score | 9 X 5 X 9=405 | 1 X 1 X 1=1 |
| # samples | 11 | 1 | |
| ** MAII score | log2(11/405*10)=-1.88041838424733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CARM1 [Title/Abstract] AND PLA2G4C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CARM1 | GO:0016571 | histone methylation | 19405910 |
| Tgene | PLA2G4C | GO:0046475 | glycerophospholipid catabolic process | 10085124 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A891-01A | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000327064 | ENST00000599111 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| Frame-shift | ENST00000327064 | ENST00000354276 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| Frame-shift | ENST00000327064 | ENST00000413144 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| Frame-shift | ENST00000327064 | ENST00000599921 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| 5CDS-5UTR | ENST00000327064 | ENST00000596510 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| Frame-shift | ENST00000344150 | ENST00000599111 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| Frame-shift | ENST00000344150 | ENST00000354276 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| Frame-shift | ENST00000344150 | ENST00000413144 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| Frame-shift | ENST00000344150 | ENST00000599921 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
| 5CDS-5UTR | ENST00000344150 | ENST00000596510 | CARM1 | chr19 | 10982598 | + | PLA2G4C | chr19 | 48558306 | - |
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FusionProtFeatures for CARM1_PLA2G4C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CARM1 | PLA2G4C |
| Methylates (mono- and asymmetric dimethylation) theguanidino nitrogens of arginyl residues in several proteinsinvolved in DNA packaging, transcription regulation, pre-mRNAsplicing, and mRNA stability. Recruited to promoters upon geneactivation together with histone acetyltransferases fromEP300/P300 and p160 families, methylates histone H3 at 'Arg-17'(H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a),leading to activate transcription via chromatin remodeling. Duringnuclear hormone receptor activation and TCF7L2/TCF4 activation,acts synergically with EP300/P300 and either one of the p160histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTRor CTNNB1/beta-catenin to activate transcription. During myogenictranscriptional activation, acts together with NCOA3/ACTR as acoactivator for MEF2C. During monocyte inflammatory stimulation,acts together with EP300/P300 as a coactivator for NF-kappa-B.Acts as coactivator for PPARG, promotes adipocyte differentiationand the accumulation of brown fat tissue. Plays a role in theregulation of pre-mRNA alternative splicing by methylation ofsplicing factors. Also seems to be involved in p53/TP53transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at'Arg-580' and 'Arg-604' in the KIX domain, which impairs itsinteraction with CREB and inhibits CREB-dependent transcriptionalactivation. Also methylates arginine residues in RNA-bindingproteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.{ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:19405910}. | Has a preference for arachidonic acid at the sn-2position of phosphatidylcholine as compared with palmitic acid.{ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:9705332}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CARM1_PLA2G4C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CARM1_PLA2G4C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CARM1 | TP53, PRMT1, PABPN1, MEF2D, MYOD1, MYOG, NRIP1, NCOA3, CREBBP, HIST1H3A, EP300, NCOA2, RELA, SRCAP, CREB1, FOS, NCOA1, GRIP1, CTNNB1, MYC, STAT5A, PARP1, NR1H4, ARID1A, SMARCA4, SMARCC2, SMARCC1, NFKB1, SMARCE1, SMARCB1, ACTB, SMARCD1, H3F3A, CEBPB, TERF2, WDR5, AXIN1, AFF1, IRF4, ELAVL1, CUL3, CUL5, CUL2, CUL1, COPS5, CAND1, RABGAP1, TP63, METTL21C, HNRNPA1, DNAJA3, NUDT21, QKI, DAXX, MALT1, PYGO1, SPAG8, UBE2I, FAF1, SUPT5H, HSPH1, ILK, PARVA, PPAT, UGP2, XPO7, DROSHA, TNRC6B, CACYBP, NUDCD3, KAT2B, KIAA1191, NECAP2, HEY2, CNN3, FOSL2, TICAM1, IL36A, TEX33, FASN, HNRNPK, PXDNL, SNRPC, CTBP1, NTRK1, KRAS, IFI16, DZIP3, MTMR14, MTMR6, MTMR8, HRSP12, CEP170B, KIAA1683, ALDOA, GTSE1, SH3BP5L, KIF16B, MED9, RBM4, HN1L, ETV4, WDR4, ARFGAP1, PRCC, DGCR14, C1orf94, RAB39B, RAB11A, ATP6V1G1, VASN, BRCA1, ESR1 | PLA2G4C | S100A10, APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CARM1_PLA2G4C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CARM1_PLA2G4C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CARM1 | C0033860 | Psoriasis | 1 | CTD_human |
| Tgene | PLA2G4C | C0036341 | Schizophrenia | 1 | PSYGENET |
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