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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5527

FusionGeneSummary for CARD11_ITGA11

check button Fusion gene summary
Fusion gene informationFusion gene name: CARD11_ITGA11
Fusion gene ID: 5527
HgeneTgene
Gene symbol

CARD11

ITGA11

Gene ID

84433

22801

Gene namecaspase recruitment domain family member 11integrin subunit alpha 11
SynonymsBENTA|BIMP3|CARMA1|IMD11|IMD11A|PPBLHsT18964
Cytomap

7p22.2

15q23

Type of geneprotein-codingprotein-coding
Descriptioncaspase recruitment domain-containing protein 11CARD-containing MAGUK protein 1bcl10-interacting maguk protein 3carma 1integrin alpha-11
Modification date2018051920180519
UniProtAcc

Q9BXL7

Q9UKX5

Ensembl transtripts involved in fusion geneENST00000396946, ENST00000315757, 
ENST00000423218, ENST00000562826, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 5 X 3=60
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CARD11 [Title/Abstract] AND ITGA11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCARD11

GO:0031295

T cell costimulation

17287217


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW339880CARD11chr7

2945832

+ITGA11chr15

68609658

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000396946ENST00000315757CARD11chr7

2945832

+ITGA11chr15

68609658

+
intron-3CDSENST00000396946ENST00000423218CARD11chr7

2945832

+ITGA11chr15

68609658

+
intron-intronENST00000396946ENST00000562826CARD11chr7

2945832

+ITGA11chr15

68609658

+

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FusionProtFeatures for CARD11_ITGA11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CARD11

Q9BXL7

ITGA11

Q9UKX5

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding toDPP4 induces T-cell proliferation and NF-kappa-B activation in aT-cell receptor/CD3-dependent manner. Activates NF-kappa-B viaBCL10 and IKK. Stimulates the phosphorylation of BCL10. Alsoactivates the TORC1 signaling pathway.{ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195,ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:28628108}. Integrin alpha-11/beta-1 is a receptor for collagen.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CARD11_ITGA11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CARD11_ITGA11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CARD11_ITGA11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CARD11_ITGA11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCARD11C0036920Sezary Syndrome2CTD_human
HgeneCARD11C0079744Diffuse Large B-Cell Lymphoma2CTD_human
HgeneCARD11C0007134Renal Cell Carcinoma1CTD_human
HgeneCARD11C0011615Dermatitis, Atopic1CTD_human
HgeneCARD11C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneCARD11C0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneCARD11C1847973Persistent Polyclonal B-Cell Lymphocytosis1ORPHANET;UNIPROT