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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5525

FusionGeneSummary for CARD10_LGALS2

check button Fusion gene summary
Fusion gene informationFusion gene name: CARD10_LGALS2
Fusion gene ID: 5525
HgeneTgene
Gene symbol

CARD10

LGALS2

Gene ID

29775

3958

Gene namecaspase recruitment domain family member 10galectin 3
SynonymsBIMP1|CARMA3CBP35|GAL3|GALBP|GALIG|L31|LGALS2|MAC2
Cytomap

22q13.1

14q22.3

Type of geneprotein-codingprotein-coding
Descriptioncaspase recruitment domain-containing protein 10Bcl10 binding protein and activator of NFKBCARD-containing MAGUK 3 proteinCARD-containing MAGUK protein 3carma 3galectin-335 kDa lectinIgE-binding proteinMAC-2 antigenadvanced glycation end-product receptor 3carbohydrate-binding protein 35galactose-specific lectin 3laminin-binding proteinlectin L-29lectin, galactoside-binding, soluble, 3
Modification date2018051920180527
UniProtAcc

Q9BWT7

P05162

Ensembl transtripts involved in fusion geneENST00000403299, ENST00000406271, 
ENST00000251973, ENST00000494166, 
ENST00000215886, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 1 X 4=16
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CARD10 [Title/Abstract] AND LGALS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCARD10

GO:0007250

activation of NF-kappaB-inducing kinase activity

11259443

TgeneLGALS2

GO:0002548

monocyte chemotaxis

10925302

TgeneLGALS2

GO:0030593

neutrophil chemotaxis

10925302

TgeneLGALS2

GO:0045806

negative regulation of endocytosis

19706535

TgeneLGALS2

GO:0048245

eosinophil chemotaxis

10925302

TgeneLGALS2

GO:0048246

macrophage chemotaxis

10925302

TgeneLGALS2

GO:0050918

positive chemotaxis

10925302

TgeneLGALS2

GO:0070232

regulation of T cell apoptotic process

8692888

TgeneLGALS2

GO:0071674

mononuclear cell migration

10925302

TgeneLGALS2

GO:0071677

positive regulation of mononuclear cell migration

10925302

TgeneLGALS2

GO:0090280

positive regulation of calcium ion import

10925302

TgeneLGALS2

GO:2001200

positive regulation of dendritic cell differentiation

16116184

TgeneLGALS2

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

22761016


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-BC-A217-01ACARD10chr22

37911980

-LGALS2chr22

37967938

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000403299ENST00000215886CARD10chr22

37911980

-LGALS2chr22

37967938

-
intron-3CDSENST00000406271ENST00000215886CARD10chr22

37911980

-LGALS2chr22

37967938

-
In-frameENST00000251973ENST00000215886CARD10chr22

37911980

-LGALS2chr22

37967938

-
intron-3CDSENST00000494166ENST00000215886CARD10chr22

37911980

-LGALS2chr22

37967938

-

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FusionProtFeatures for CARD10_LGALS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CARD10

Q9BWT7

LGALS2

P05162

Activates NF-kappa-B via BCL10 and IKK. This protein binds beta-galactoside. Its physiologicalfunction is not yet known.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CARD10_LGALS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CARD10_LGALS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CARD10BCL10, ATXN7, IKBKG, CARD10, KLHL12, GFOD1, CAPZA2, DBN1, MYO1C, KIF20A, MYO19, CDC5L, FAM167ALGALS2IKBKG, APP, LTA, TUBA1B, TUBB, SDCBP, SDCBP2, TRIM16


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CARD10_LGALS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CARD10_LGALS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLGALS2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneLGALS2C0027051Myocardial Infarction1CTD_human
TgeneLGALS2C0520459Necrotizing Enterocolitis1CTD_human