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Fusion gene ID: 5516 |
FusionGeneSummary for CAPZB_ITGB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CAPZB_ITGB1 | Fusion gene ID: 5516 | Hgene | Tgene | Gene symbol | CAPZB | ITGB1 | Gene ID | 832 | 3688 |
| Gene name | capping actin protein of muscle Z-line subunit beta | integrin subunit beta 1 | |
| Synonyms | CAPB|CAPPB|CAPZ | CD29|FNRB|GPIIA|MDF2|MSK12|VLA-BETA|VLAB | |
| Cytomap | 1p36.13 | 10p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, beta | integrin beta-1glycoprotein IIaintegrin VLA-4 beta subunitintegrin beta 1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)very late activation protein, beta polypeptide | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P47756 | P05556 | |
| Ensembl transtripts involved in fusion gene | ENST00000401084, ENST00000264203, ENST00000375142, ENST00000433834, ENST00000264202, ENST00000482808, ENST00000375144, | ENST00000423113, ENST00000396033, ENST00000302278, ENST00000374956, ENST00000484088, | |
| Fusion gene scores | * DoF score | 14 X 14 X 9=1764 | 4 X 5 X 2=40 |
| # samples | 22 | 5 | |
| ** MAII score | log2(22/1764*10)=-3.00327513203286 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CAPZB [Title/Abstract] AND ITGB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ITGB1 | GO:0007159 | leukocyte cell-cell adhesion | 1715889 |
| Tgene | ITGB1 | GO:0010710 | regulation of collagen catabolic process | 10455171 |
| Tgene | ITGB1 | GO:0033627 | cell adhesion mediated by integrin | 12807887|17158881 |
| Tgene | ITGB1 | GO:0051897 | positive regulation of protein kinase B signaling | 24044949 |
| Tgene | ITGB1 | GO:1903078 | positive regulation of protein localization to plasma membrane | 10455171 |
| Tgene | ITGB1 | GO:2000273 | positive regulation of signaling receptor activity | 24044949 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA420172 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000401084 | ENST00000423113 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000401084 | ENST00000396033 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000401084 | ENST00000302278 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000401084 | ENST00000374956 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-intron | ENST00000401084 | ENST00000484088 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000264203 | ENST00000423113 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000264203 | ENST00000396033 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000264203 | ENST00000302278 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000264203 | ENST00000374956 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-intron | ENST00000264203 | ENST00000484088 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000375142 | ENST00000423113 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000375142 | ENST00000396033 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000375142 | ENST00000302278 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000375142 | ENST00000374956 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-intron | ENST00000375142 | ENST00000484088 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000433834 | ENST00000423113 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000433834 | ENST00000396033 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000433834 | ENST00000302278 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000433834 | ENST00000374956 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-intron | ENST00000433834 | ENST00000484088 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000264202 | ENST00000423113 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000264202 | ENST00000396033 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000264202 | ENST00000302278 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000264202 | ENST00000374956 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-intron | ENST00000264202 | ENST00000484088 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000482808 | ENST00000423113 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000482808 | ENST00000396033 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000482808 | ENST00000302278 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000482808 | ENST00000374956 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-intron | ENST00000482808 | ENST00000484088 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000375144 | ENST00000423113 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000375144 | ENST00000396033 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000375144 | ENST00000302278 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-3CDS | ENST00000375144 | ENST00000374956 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
| intron-intron | ENST00000375144 | ENST00000484088 | CAPZB | chr1 | 19665947 | + | ITGB1 | chr10 | 33200902 | - |
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FusionProtFeatures for CAPZB_ITGB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CAPZB | ITGB1 |
| F-actin-capping proteins bind in a Ca(2+)-independentmanner to the fast growing ends of actin filaments (barbed end)thereby blocking the exchange of subunits at these ends. Unlikeother capping proteins (such as gelsolin and severin), theseproteins do not sever actin filaments. Plays a role in theregulation of cell morphology and cytoskeletal organization.{ECO:0000269|PubMed:21834987}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CAPZB_ITGB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CAPZB_ITGB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CAPZB_ITGB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | ITGB1 | P05556 | DB00098 | Antithymocyte immunoglobulin (rabbit) | Integrin beta-1 | biotech | approved |
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RelatedDiseases for CAPZB_ITGB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CAPZB | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | CAPZB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | CAPZB | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
| Tgene | ITGB1 | C0006663 | Calcinosis | 1 | CTD_human |
| Tgene | ITGB1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | ITGB1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | ITGB1 | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
| Tgene | ITGB1 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | ITGB1 | C0017639 | Gliosis | 1 | CTD_human |
| Tgene | ITGB1 | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | ITGB1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | ITGB1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | ITGB1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | ITGB1 | C0878544 | Cardiomyopathies | 1 | CTD_human |
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