FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5511

FusionGeneSummary for CAPZB_APITD1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPZB_APITD1
Fusion gene ID: 5511
HgeneTgene
Gene symbol

CAPZB

APITD1

Gene ID

832

378708

Gene namecapping actin protein of muscle Z-line subunit betacentromere protein S
SynonymsCAPB|CAPPB|CAPZAPITD1|CENP-S|FAAP16|MHF1
Cytomap

1p36.13

1p36.22

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betacentromere protein SFANCM associated histone fold protein 1FANCM-interacting histone fold protein 1Fanconi anemia-associated polypeptide of 16 kDaapoptosis-inducing TAF9-like domain-containing protein 1apoptosis-inducing, TAF9-like domain 1
Modification date2018052320180523
UniProtAcc

P47756

Ensembl transtripts involved in fusion geneENST00000401084, ENST00000264203, 
ENST00000375142, ENST00000433834, 
ENST00000264202, ENST00000482808, 
ENST00000375144, 		ENST00000602296, 
ENST00000602787, ENST00000309048, 
ENST00000462462, 
Fusion gene scores* DoF score14 X 14 X 9=17641 X 1 X 1=1
# samples 221
** MAII scorelog2(22/1764*10)=-3.00327513203286
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: CAPZB [Title/Abstract] AND APITD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAPITD1

GO:0006281

DNA repair

20347429

TgeneAPITD1

GO:0006974

cellular response to DNA damage stimulus

20347429


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-B5-A0JN-01ACAPZBchr1

19811930

-APITD1chr1

10500404

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000401084ENST00000602296CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-intronENST00000401084ENST00000602787CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-intronENST00000401084ENST00000309048CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-3UTRENST00000401084ENST00000462462CAPZBchr1

19811930

-APITD1chr1

10500404

+
5UTR-intronENST00000264203ENST00000602296CAPZBchr1

19811930

-APITD1chr1

10500404

+
5UTR-intronENST00000264203ENST00000602787CAPZBchr1

19811930

-APITD1chr1

10500404

+
5UTR-intronENST00000264203ENST00000309048CAPZBchr1

19811930

-APITD1chr1

10500404

+
5UTR-3UTRENST00000264203ENST00000462462CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-intronENST00000375142ENST00000602296CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-intronENST00000375142ENST00000602787CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-intronENST00000375142ENST00000309048CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-3UTRENST00000375142ENST00000462462CAPZBchr1

19811930

-APITD1chr1

10500404

+
intron-intronENST00000433834ENST00000602296CAPZBchr1

19811930

-APITD1chr1

10500404

+
intron-intronENST00000433834ENST00000602787CAPZBchr1

19811930

-APITD1chr1

10500404

+
intron-intronENST00000433834ENST00000309048CAPZBchr1

19811930

-APITD1chr1

10500404

+
intron-3UTRENST00000433834ENST00000462462CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-intronENST00000264202ENST00000602296CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-intronENST00000264202ENST00000602787CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-intronENST00000264202ENST00000309048CAPZBchr1

19811930

-APITD1chr1

10500404

+
5CDS-3UTRENST00000264202ENST00000462462CAPZBchr1

19811930

-APITD1chr1

10500404

+
5UTR-intronENST00000482808ENST00000602296CAPZBchr1

19811930

-APITD1chr1

10500404

+
5UTR-intronENST00000482808ENST00000602787CAPZBchr1

19811930

-APITD1chr1

10500404

+
5UTR-intronENST00000482808ENST00000309048CAPZBchr1

19811930

-APITD1chr1

10500404

+
5UTR-3UTRENST00000482808ENST00000462462CAPZBchr1

19811930

-APITD1chr1

10500404

+
intron-intronENST00000375144ENST00000602296CAPZBchr1

19811930

-APITD1chr1

10500404

+
intron-intronENST00000375144ENST00000602787CAPZBchr1

19811930

-APITD1chr1

10500404

+
intron-intronENST00000375144ENST00000309048CAPZBchr1

19811930

-APITD1chr1

10500404

+
intron-3UTRENST00000375144ENST00000462462CAPZBchr1

19811930

-APITD1chr1

10500404

+

Top

FusionProtFeatures for CAPZB_APITD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPZB

P47756

APITD1

F-actin-capping proteins bind in a Ca(2+)-independentmanner to the fast growing ends of actin filaments (barbed end)thereby blocking the exchange of subunits at these ends. Unlikeother capping proteins (such as gelsolin and severin), theseproteins do not sever actin filaments. Plays a role in theregulation of cell morphology and cytoskeletal organization.{ECO:0000269|PubMed:21834987}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CAPZB_APITD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CAPZB_APITD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAPZBTWF2, MRPL20, PTN, BCCIP, UIMC1, DMWD, MEPCE, PPP2R2B, RPP14, BLNK, SP1, CD2AP, UBE2Q2, CDK2, FAM21C, ARHGAP17, LRRK2, BAG3, HSPA8, CAPZA1, ESR1, BRCA1, MDC1, PAXIP1, TP53BP1, MAGOH, EIF4A3, FN1, VCAM1, ITGA4, PAN2, VHL, FBXO6, HECW2, AHCY, CAPZA2, DCTPP1, HEXA, TUBB3, PAPSS1, TP53, HUWE1, CUL7, OBSL1, CCDC8, BMI1, SIRT6, DAPK1, MARK3, STAP1, PLEKHO2, SH3KBP1, ARPC2, ARPC3, ARPC5, ARPC5L, DCTN2, DCTN4, DLD, LRRC16A, MCFD2, PCID2, CNOT2, DCTN1, DCTN6, DDX53, MYO5B, NAPA, RPAP3, TMOD3, TOMM40, TPM2, UBL7, NTRK1, RPGRIP1L, DBN1, MARK2, FLNA, GAK, MYH9, MYH11, PPP1CB, PPP1CC, VCL, IQGAP1, PDLIM7, VPS26A, SYNPO, CNOT1, LIMA1, ANLN, MYO5C, MYO19, MYO18A, MCM2, GLI1, U2AF2, CDC73, CDH1, DUSP8, RCSD1, PLEKHO1, ACTR1B, STYX, COX15, TRIM25, TES, RNF169APITD1FANCM, FANCA, FANCG, FANCF, FANCB, C17orf70, STRA13, FANCL, BLM, TOP3A, RMI1, C19orf40, RMI2, C1orf86, APP, RPA1, FANCE, FANCC, RPA2, HOMEZ, CENPO, CENPT, CENPK, CENPU, CENPH, APITD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CAPZB_APITD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CAPZB_APITD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAPZBC0024667Animal Mammary Neoplasms1CTD_human
HgeneCAPZBC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCAPZBC0948089Acute Coronary Syndrome1CTD_human