FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5505

FusionGeneSummary for CAPZA2_ABCB1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPZA2_ABCB1
Fusion gene ID: 5505
HgeneTgene
Gene symbol

CAPZA2

ABCB1

Gene ID

830

5243

Gene namecapping actin protein of muscle Z-line subunit alpha 2ATP binding cassette subfamily B member 1
SynonymsCAPPA2|CAPZABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1
Cytomap

7q31.2

7q21.12

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit alpha-2F-actin capping protein alpha-2 subunitcapZ alpha-2capping actin protein of muscle Z-line alpha subunit 2capping protein (actin filament) muscle Z-line, alpha 2multidrug resistance protein 1ATP-binding cassette, sub-family B (MDR/TAP), member 1P glycoproteinP-glycoprotein 1colchicin sensitivitydoxorubicin resistance
Modification date2018052320180527
UniProtAcc

P47755

P08183

Ensembl transtripts involved in fusion geneENST00000361183, ENST00000458284, 
ENST00000490693, ENST00000466023, 
ENST00000265724, ENST00000543898, 
ENST00000488737, 
Fusion gene scores* DoF score5 X 4 X 7=1404 X 4 X 3=48
# samples 74
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPZA2 [Title/Abstract] AND ABCB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCB1

GO:0000086

G2/M transition of mitotic cell cycle

19384922

TgeneABCB1

GO:0045332

phospholipid translocation

8898203

TgeneABCB1

GO:0099040

ceramide translocation

8898203


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-A73F-01ACAPZA2chr7

116451156

+ABCB1chr7

87168661

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000361183ENST00000265724CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-3CDSENST00000361183ENST00000543898CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-intronENST00000361183ENST00000488737CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-3CDSENST00000458284ENST00000265724CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-3CDSENST00000458284ENST00000543898CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-intronENST00000458284ENST00000488737CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-3CDSENST00000490693ENST00000265724CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-3CDSENST00000490693ENST00000543898CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-intronENST00000490693ENST00000488737CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-3CDSENST00000466023ENST00000265724CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-3CDSENST00000466023ENST00000543898CAPZA2chr7

116451156

+ABCB1chr7

87168661

-
intron-intronENST00000466023ENST00000488737CAPZA2chr7

116451156

+ABCB1chr7

87168661

-

Top

FusionProtFeatures for CAPZA2_ABCB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPZA2

P47755

ABCB1

P08183

F-actin-capping proteins bind in a Ca(2+)-independentmanner to the fast growing ends of actin filaments (barbed end)thereby blocking the exchange of subunits at these ends. Unlikeother capping proteins (such as gelsolin and severin), theseproteins do not sever actin filaments. Energy-dependent efflux pump responsible for decreaseddrug accumulation in multidrug-resistant cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CAPZA2_ABCB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CAPZA2_ABCB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAPZA2TWF2, RBBP6, ELAVL1, ARRB2, BLNK, CD2AP, LRRK2, PAN2, AASDHPPT, CAPZA1, PTMA, PSMG1, RPL18A, SGTA, STRAP, CAPZB, PKM, CUL7, OBSL1, CCDC8, DAPK1, CSPP1, STAP1, ACTR1B, ACTR1A, ARAP1, CNOT3, KIAA1671, MTCL1, CNOT10, CNOT1, FAM21C, FAM21A, RLTPR, KIAA1033, DCTN1, LRRC16A, KIAA0196, DCTN3, PLEKHO2, TNKS1BP1, SVIL, SH3KBP1, KIAA1211, DCTN2, DCTN4, CNOT2, RQCD1, SH3BP1, ACTR10, CNOT8, PLEKHO1, CNOT11, DCTN5, CNOT7, CCS, CNOT6, CNOT6L, WASH6P, WASH3P, RAVER1, PPP1R9A, DCTN6, FHL2, CCDC53, RBM18, ARPC2, ACTR2, ARPC3, PSMB6, MYO5A, MYO5C, HSPB2, RPGRIP1L, ACTA1, ACTG1, ACTN4, ACTN1, ADD1, ADD3, AP2A1, ALDH3A2, DST, BST2, CAMK2G, DBN1, MARK2, FLNA, MLH1, MYH9, MYO1C, PCDH7, PPP1CB, IQGAP1, PDLIM7, SYNPO, ANLN, MYO19, MYO18A, CFL1, CFL2, AP2M1, CLIC1, CLTA, CLTB, CLTC, COX6C, CPM, DAB2, DAPK3, CTTN, EPS15, FDX1, FLII, FLNB, GNAI2, GSN, HADHA, ITPR1, ITPR2, ITPR3, ABLIM1, LMO7, MLLT4, MYO1B, MYH10, MYO1E, MYO5B, MYO6, PPP1R12A, NAP1L1, NAP1L4, OGDH, ORC4, PFKM, PIK3C2A, PLEC, PPP1CA, PSMC5, PSMD4, TWF1, RAB1A, SIPA1, SPTAN1, SPTBN1, SPTBN2, SSFA2, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, TPM4, CORO2A, LUZP1, CLTCL1, PICALM, SORBS2, PKP4, NUMB, HIP1R, LRRFIP2, MTFR1, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC5, ARPC4, ARPC1B, ACTR3, LRPPRC, FARP1, FLOT1, CDIPT, IPO7, SMC2, MYL12A, GAS2L1, TRIOBP, AKAP2, LIMCH1, SIPA1L3, N4BP3, MPRIP, COBL, SPECC1L, FBXO46, MACF1, CORO1C, PLEKHG3, RAI14, TIMM13, RACGAP1, PACSIN3, TMOD3, CARD10, LIMA1, GTSE1, NCKIPSD, LIN7C, BMP2K, UNC45A, CORO1B, CGN, MICAL3, STAMBPL1, ARHGAP21, AFAP1, ZNF106, INF2, INTS3, AHNAK, TANGO6, WDR76, BICC1, ARPC5L, KCTD10, FAM161A, TUBB6, MYPN, PPP1R9B, LRCH3, STON2, DOCK7, DIXDC1, SSH2, PHLDB2, NEXN, SPECC1, FCHO2, FGD4, MISP, CHMP4B, MYL6B, ARHGAP42, AMOTL1, PPP1R18, GAS2L3, TPRN, MCM2, GLI1, DUSP8, RCSD1, STYX, DLST, TRIM25, G3BP1ABCB1DHX9, PIM1, LNX1, PSMB8, FBXO15, UBA7, MAPKAP1, CD4, BCCIP, MAPRE1, CUL7, LGALS3, NEDD4, NTRK1, FBXL13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CAPZA2_ABCB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneABCB1P08183DB09031MiltefosineMultidrug resistance protein 1small moleculeapproved|investigational
TgeneABCB1P08183DB00778RoxithromycinMultidrug resistance protein 1small moleculeapproved|investigational|withdrawn

Top

RelatedDiseases for CAPZA2_ABCB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABCB1C0011570Mental Depression5PSYGENET
TgeneABCB1C0011581Depressive disorder5PSYGENET
TgeneABCB1C0041696Unipolar Depression5PSYGENET
TgeneABCB1C1269683Major Depressive Disorder5PSYGENET
TgeneABCB1C0036341Schizophrenia4PSYGENET
TgeneABCB1C0041755Adverse reaction to drug4CTD_human
TgeneABCB1C0003873Rheumatoid Arthritis2CTD_human
TgeneABCB1C0005586Bipolar Disorder2PSYGENET
TgeneABCB1C0009404Colorectal Neoplasms2CTD_human
TgeneABCB1C0014544Epilepsy2CTD_human
TgeneABCB1C0027765nervous system disorder2CTD_human
TgeneABCB1C0027947Neutropenia2CTD_human
TgeneABCB1C0004936Mental disorders1CTD_human
TgeneABCB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneABCB1C0014836Escherichia coli Infections1CTD_human
TgeneABCB1C0014859Esophageal Neoplasms1CTD_human
TgeneABCB1C0018798Congenital Heart Defects1CTD_human
TgeneABCB1C0020651Hypotension, Orthostatic1CTD_human
TgeneABCB1C0022665Kidney Neoplasm1CTD_human
TgeneABCB1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneABCB1C0024809Marijuana Abuse1CTD_human
TgeneABCB1C0027497Nausea1CTD_human
TgeneABCB1C0027609Neonatal Abstinence Syndrome1PSYGENET
TgeneABCB1C0027627Neoplasm Metastasis1CTD_human
TgeneABCB1C0027819Neuroblastoma1CTD_human
TgeneABCB1C0030201Pain, Postoperative1CTD_human
TgeneABCB1C0030567Parkinson Disease1CTD_human
TgeneABCB1C0030569Secondary Parkinson Disease1CTD_human
TgeneABCB1C0031117Peripheral Neuropathy1CTD_human
TgeneABCB1C0033975Psychotic Disorders1PSYGENET
TgeneABCB1C0040715Chromosomal translocation1CTD_human
TgeneABCB1C0042963Vomiting1CTD_human
TgeneABCB1C0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneABCB1C0206686Adrenocortical carcinoma1CTD_human
TgeneABCB1C0235032Neurotoxicity Syndromes1CTD_human
TgeneABCB1C0338831Manic1PSYGENET
TgeneABCB1C0376545Hematologic Neoplasms1CTD_human
TgeneABCB1C0993582Arthritis, Experimental1CTD_human
TgeneABCB1C1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneABCB1C1458155Mammary Neoplasms1CTD_human
TgeneABCB1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneABCB1C2239176Liver carcinoma1CTD_human
TgeneABCB1C4277682Chemical and Drug Induced Liver Injury1CTD_human