FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5492

FusionGeneSummary for CAPRIN1_THOC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPRIN1_THOC1
Fusion gene ID: 5492
HgeneTgene
Gene symbol

CAPRIN1

THOC1

Gene ID

4076

9984

Gene namecell cycle associated protein 1THO complex 1
SynonymsGPIAP1|GPIP137|GRIP137|M11S1|RNG105|p137GPIHPR1|P84|P84N5
Cytomap

11p13

18p11.32

Type of geneprotein-codingprotein-coding
Descriptioncaprin-1GPI-anchored membrane protein 1GPI-anchored protein p137GPI-p137RNA granule protein 105activation/proliferation-associated protein 1caprin 1cytoplasmic activation- and proliferation-associated protein 1cytoplasmic activation/proliferation-THO complex subunit 1hTREX84nuclear matrix protein p84tho1
Modification date2018051920180523
UniProtAcc

Q14444

Q96FV9

Ensembl transtripts involved in fusion geneENST00000341394, ENST00000389645, 
ENST00000532820, ENST00000530820, 
ENST00000529307, ENST00000533657, 
ENST00000261600, ENST00000582313, 
Fusion gene scores* DoF score8 X 8 X 6=3844 X 5 X 3=60
# samples 86
** MAII scorelog2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: CAPRIN1 [Title/Abstract] AND THOC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTHOC1

GO:0006406

mRNA export from nucleus

17190602

TgeneTHOC1

GO:0006915

apoptotic process

10512864

TgeneTHOC1

GO:0032784

regulation of DNA-templated transcription, elongation

15870275

TgeneTHOC1

GO:0046784

viral mRNA export from host cell nucleus

18974867


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-EO-A3KU-01ACAPRIN1chr11

34074586

+THOC1chr18

224994

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341394ENST00000261600CAPRIN1chr11

34074586

+THOC1chr18

224994

-
intron-intronENST00000341394ENST00000582313CAPRIN1chr11

34074586

+THOC1chr18

224994

-
intron-3CDSENST00000389645ENST00000261600CAPRIN1chr11

34074586

+THOC1chr18

224994

-
intron-intronENST00000389645ENST00000582313CAPRIN1chr11

34074586

+THOC1chr18

224994

-
intron-3CDSENST00000532820ENST00000261600CAPRIN1chr11

34074586

+THOC1chr18

224994

-
intron-intronENST00000532820ENST00000582313CAPRIN1chr11

34074586

+THOC1chr18

224994

-
intron-3CDSENST00000530820ENST00000261600CAPRIN1chr11

34074586

+THOC1chr18

224994

-
intron-intronENST00000530820ENST00000582313CAPRIN1chr11

34074586

+THOC1chr18

224994

-
5UTR-3CDSENST00000529307ENST00000261600CAPRIN1chr11

34074586

+THOC1chr18

224994

-
5UTR-intronENST00000529307ENST00000582313CAPRIN1chr11

34074586

+THOC1chr18

224994

-
intron-3CDSENST00000533657ENST00000261600CAPRIN1chr11

34074586

+THOC1chr18

224994

-
intron-intronENST00000533657ENST00000582313CAPRIN1chr11

34074586

+THOC1chr18

224994

-

Top

FusionProtFeatures for CAPRIN1_THOC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPRIN1

Q14444

THOC1

Q96FV9

May regulate the transport and translation of mRNAs ofproteins involved in synaptic plasticity in neurons and cellproliferation and migration in multiple cell types. Binds directlyand selectively to MYC and CCND2 RNAs. In neuronal cells, directlybinds to several mRNAs associated with RNA granules, includingBDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 andKPNB1 mRNAs, but not to rRNAs. {ECO:0000269|PubMed:17210633}. Required for efficient export of polyadenylated RNA.Acts as component of the THO subcomplex of the TREX complex whichis thought to couple mRNA transcription, processing and nuclearexport, and which specifically associates with spliced mRNA andnot with unspliced pre-mRNA. TREX is recruited to spliced mRNAs bya transcription-independent mechanism, binds to mRNA upstream ofthe exon-junction complex (EJC) and is recruited in asplicing- and cap-dependent manner to a region near the 5' end ofthe mRNA where it functions in mRNA export to the cytoplasm viathe TAP/NFX1 pathway. The TREX complex is essential for the exportof Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAsand infectious virus production. Regulates transcriptionalelongation of a subset of genes. Involved in genome stability bypreventing co-transcriptional R-loop formation. Participates in an apoptotic pathway which ischaracterized by activation of caspase-6, increases in theexpression of BAK1 and BCL2L1 and activation of NF-kappa-B. Thispathway does not require p53/TP53, nor does the presence ofp53/TP53 affect the efficiency of cell killing. Activates a G2/Mcell cycle checkpoint prior to the onset of apoptosis. Apoptosisis inhibited by association with RB1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CAPRIN1_THOC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CAPRIN1_THOC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAPRIN1PINX1, PRMT1, G3BP1, GIGYF2, SIRT7, TSG101, CUL3, CUL1, COPS5, CAND1, APP, CIRBP, ESR1, IGSF8, FBXO6, TARDBP, WBP4, PIN1, RPA3, RPA2, RPA1, FXR1, FXR2, STAU1, RNF2, BMI1, SIRT6, CDK2, ILK, RPS6KB2, HNRNPA1, NTRK1, RPL7, YBX1, NF2, EGFR, CYLD, DNM1L, BRCA1, RPS6, G3BP2THOC1RB1, DDX39B, ALYREF, THOC2, THOC5, NCBP1, THOC3, THOC7, THOC6, IK, SF3B2, SF3B1, ZCCHC8, UTRN, ZC3H15, UBR7, RRP9, XPO4, VPS53, TRMT112, TPM3, TPM1, USP13, ZNF830, DHX8, THOC1, FRA10AC1, SAP30BP, WDR77, RPA3, RPA2, RPA1, RABGEF1, TRIM54, MOAP1, USHBP1, OBSL1, RNF2, LUZP4, DSCC1, KRAS, ADAR, DHX9, FMR1, GSN, PRMT1, SP110, NFKBIL1, FXR1, DUSP11, TOP3B, BCLAF1, EIF4A3, ZC3H11A, THRAP3, C17orf85, DDX39A, KIF1C, B4GALT7, ZC3H13, ZZEF1, ZC3H3, CHTOP, RBM15B, MRPS17, GTSE1, C14orf166, RBM27, BCCIP, SCAF1, ZC3H14, CAAP1, TDRD3, FYTTD1, POLDIP3, SARNP, PWWP2A, ATG4A, TARSL2, C19orf47, RBM33, ZFC3H1, C15orf52, NEDD4, MRPL12, MTNR1B, DLST, PDHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CAPRIN1_THOC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CAPRIN1_THOC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource