FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5488

FusionGeneSummary for CAPRIN1_CAPRIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPRIN1_CAPRIN1
Fusion gene ID: 5488
HgeneTgene
Gene symbol

CAPRIN1

CAPRIN1

Gene ID

4076

4076

Gene namecell cycle associated protein 1cell cycle associated protein 1
SynonymsGPIAP1|GPIP137|GRIP137|M11S1|RNG105|p137GPIGPIAP1|GPIP137|GRIP137|M11S1|RNG105|p137GPI
Cytomap

11p13

11p13

Type of geneprotein-codingprotein-coding
Descriptioncaprin-1GPI-anchored membrane protein 1GPI-anchored protein p137GPI-p137RNA granule protein 105activation/proliferation-associated protein 1caprin 1cytoplasmic activation- and proliferation-associated protein 1cytoplasmic activation/proliferation-caprin-1GPI-anchored membrane protein 1GPI-anchored protein p137GPI-p137RNA granule protein 105activation/proliferation-associated protein 1caprin 1cytoplasmic activation- and proliferation-associated protein 1cytoplasmic activation/proliferation-
Modification date2018051920180519
UniProtAcc

Q14444

Q14444

Ensembl transtripts involved in fusion geneENST00000341394, ENST00000389645, 
ENST00000532820, ENST00000530820, 
ENST00000529307, ENST00000533657, 
ENST00000341394, ENST00000389645, 
ENST00000532820, ENST00000530820, 
ENST00000529307, ENST00000533657, 
Fusion gene scores* DoF score8 X 8 X 6=3846 X 5 X 4=120
# samples 88
** MAII scorelog2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPRIN1 [Title/Abstract] AND CAPRIN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ215232CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000341394ENST00000341394CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-intronENST00000341394ENST00000389645CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-intronENST00000341394ENST00000532820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-intronENST00000341394ENST00000530820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-intronENST00000341394ENST00000529307CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-3UTRENST00000341394ENST00000533657CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-3UTRENST00000389645ENST00000341394CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000389645ENST00000389645CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000389645ENST00000532820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000389645ENST00000530820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000389645ENST00000529307CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-3UTRENST00000389645ENST00000533657CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-3UTRENST00000532820ENST00000341394CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000532820ENST00000389645CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000532820ENST00000532820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000532820ENST00000530820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000532820ENST00000529307CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-3UTRENST00000532820ENST00000533657CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-3UTRENST00000530820ENST00000341394CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000530820ENST00000389645CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000530820ENST00000532820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000530820ENST00000530820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000530820ENST00000529307CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-3UTRENST00000530820ENST00000533657CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-3UTRENST00000529307ENST00000341394CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000529307ENST00000389645CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000529307ENST00000532820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000529307ENST00000530820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-intronENST00000529307ENST00000529307CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
intron-3UTRENST00000529307ENST00000533657CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-3UTRENST00000533657ENST00000341394CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-intronENST00000533657ENST00000389645CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-intronENST00000533657ENST00000532820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-intronENST00000533657ENST00000530820CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-intronENST00000533657ENST00000529307CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+
3UTR-3UTRENST00000533657ENST00000533657CAPRIN1chr11

34122200

-CAPRIN1chr11

34122240

+

Top

FusionProtFeatures for CAPRIN1_CAPRIN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPRIN1

Q14444

CAPRIN1

Q14444

May regulate the transport and translation of mRNAs ofproteins involved in synaptic plasticity in neurons and cellproliferation and migration in multiple cell types. Binds directlyand selectively to MYC and CCND2 RNAs. In neuronal cells, directlybinds to several mRNAs associated with RNA granules, includingBDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 andKPNB1 mRNAs, but not to rRNAs. {ECO:0000269|PubMed:17210633}. May regulate the transport and translation of mRNAs ofproteins involved in synaptic plasticity in neurons and cellproliferation and migration in multiple cell types. Binds directlyand selectively to MYC and CCND2 RNAs. In neuronal cells, directlybinds to several mRNAs associated with RNA granules, includingBDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 andKPNB1 mRNAs, but not to rRNAs. {ECO:0000269|PubMed:17210633}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CAPRIN1_CAPRIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CAPRIN1_CAPRIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CAPRIN1_CAPRIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CAPRIN1_CAPRIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource