	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 5473

FusionGeneSummary for CAPNS1_CAPNS1

Fusion gene summary

Fusion gene information	Fusion gene name: CAPNS1_CAPNS1
	Fusion gene ID: 5473
		Hgene	Tgene
	Gene symbol	CAPNS1	CAPNS1
	Gene ID	826	826
	Gene name	calpain small subunit 1	calpain small subunit 1
	Synonyms	CALPAIN4\|CANP\|CANPS\|CAPN4\|CDPS\|CSS1	CALPAIN4\|CANP\|CANPS\|CAPN4\|CDPS\|CSS1
	Cytomap	19q13.12	19q13.12
	Type of gene	protein-coding	protein-coding
	Description	calpain small subunit 1CANP small subunitcalcium-activated neutral proteinase small subunitcalcium-dependent protease small subunit 1calcium-dependent protease, small subunitcalpain 4, small subunit (30K)calpain regulatory subunitcalpain, small pol	calpain small subunit 1CANP small subunitcalcium-activated neutral proteinase small subunitcalcium-dependent protease small subunit 1calcium-dependent protease, small subunitcalpain 4, small subunit (30K)calpain regulatory subunitcalpain, small pol
	Modification date	20180522	20180522
	UniProtAcc	P04632	P04632
	Ensembl transtripts involved in fusion gene	ENST00000246533, ENST00000589146, ENST00000587718, ENST00000590874, ENST00000588815, ENST00000588780,	ENST00000246533, ENST00000589146, ENST00000587718, ENST00000590874, ENST00000588815, ENST00000588780,
Fusion gene scores	* DoF score	13 X 12 X 5=780	5 X 6 X 1=30
	# samples	14	7
	** MAII score	log2(14/780*10)=-2.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/30*10)=1.22239242133645 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CAPNS1 [Title/Abstract] AND CAPNS1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW366590	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
ChiTaRS3.1			AW405342	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000246533	ENST00000246533	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000246533	ENST00000589146	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000246533	ENST00000587718	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000246533	ENST00000590874	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000246533	ENST00000588815	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000246533	ENST00000588780	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
intron-3UTR	ENST00000589146	ENST00000246533	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
intron-intron	ENST00000589146	ENST00000589146	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
intron-3UTR	ENST00000589146	ENST00000587718	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
intron-intron	ENST00000589146	ENST00000590874	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
intron-3UTR	ENST00000589146	ENST00000588815	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
intron-intron	ENST00000589146	ENST00000588780	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000587718	ENST00000246533	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000587718	ENST00000589146	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000587718	ENST00000587718	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000587718	ENST00000590874	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000587718	ENST00000588815	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000587718	ENST00000588780	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000590874	ENST00000246533	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000590874	ENST00000589146	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000590874	ENST00000587718	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000590874	ENST00000590874	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000590874	ENST00000588815	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000590874	ENST00000588780	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000588815	ENST00000246533	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000588815	ENST00000589146	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000588815	ENST00000587718	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000588815	ENST00000590874	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000588815	ENST00000588815	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000588815	ENST00000588780	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000588780	ENST00000246533	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000588780	ENST00000589146	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000588780	ENST00000587718	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000588780	ENST00000590874	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-3UTR	ENST00000588780	ENST00000588815	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
5CDS-intron	ENST00000588780	ENST00000588780	CAPNS1	chr19	36636912	-	CAPNS1	chr19	36641152	+
3UTR-3CDS	ENST00000246533	ENST00000246533	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000246533	ENST00000589146	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000246533	ENST00000587718	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000246533	ENST00000590874	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000246533	ENST00000588815	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000246533	ENST00000588780	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-3CDS	ENST00000589146	ENST00000246533	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000589146	ENST00000589146	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000589146	ENST00000587718	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000589146	ENST00000590874	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000589146	ENST00000588815	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000589146	ENST00000588780	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-3CDS	ENST00000587718	ENST00000246533	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000587718	ENST00000589146	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000587718	ENST00000587718	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000587718	ENST00000590874	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000587718	ENST00000588815	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000587718	ENST00000588780	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-3CDS	ENST00000590874	ENST00000246533	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000590874	ENST00000589146	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000590874	ENST00000587718	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000590874	ENST00000590874	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000590874	ENST00000588815	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000590874	ENST00000588780	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-3CDS	ENST00000588815	ENST00000246533	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000588815	ENST00000589146	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000588815	ENST00000587718	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000588815	ENST00000590874	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000588815	ENST00000588815	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
3UTR-intron	ENST00000588815	ENST00000588780	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-3CDS	ENST00000588780	ENST00000246533	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000588780	ENST00000589146	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000588780	ENST00000587718	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000588780	ENST00000590874	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000588780	ENST00000588815	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+
intron-intron	ENST00000588780	ENST00000588780	CAPNS1	chr19	36640961	+	CAPNS1	chr19	36633620	+

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FusionProtFeatures for CAPNS1_CAPNS1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAPNS1 P04632	CAPNS1 P04632
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis ofsubstrates involved in cytoskeletal remodeling and signaltransduction.	Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis ofsubstrates involved in cytoskeletal remodeling and signaltransduction.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CAPNS1_CAPNS1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAPNS1_CAPNS1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CAPNS1_CAPNS1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CAPNS1_CAPNS1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CAPNS1	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	CAPNS1	C0033578	Prostatic Neoplasms	1	CTD_human

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Fusion gene ID: 5473

FusionGeneSummary for CAPNS1_CAPNS1

FusionProtFeatures for CAPNS1_CAPNS1

FusionGeneSequence for CAPNS1_CAPNS1

FusionGenePPI for CAPNS1_CAPNS1

RelatedDrugs for CAPNS1_CAPNS1

RelatedDiseases for CAPNS1_CAPNS1