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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5471

FusionGeneSummary for CAPN7_ACTR2

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPN7_ACTR2
Fusion gene ID: 5471
HgeneTgene
Gene symbol

CAPN7

ACTR2

Gene ID

23473

10097

Gene namecalpain 7ARP2 actin related protein 2 homolog
SynonymsCALPAIN7|PALBHARP2
Cytomap

3p25.1

2p14

Type of geneprotein-codingprotein-coding
Descriptioncalpain-7calpain like proteasehomolog of Aspergillus Nidulans PALBpalB homologactin-related protein 2actin-like protein 2
Modification date2018052220180519
UniProtAcc

Q9Y6W3

P61160

Ensembl transtripts involved in fusion geneENST00000253693, ENST00000260641, 
ENST00000476840, ENST00000542850, 
ENST00000377982, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 2=24
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CAPN7 [Title/Abstract] AND ACTR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAPN7

GO:0010634

positive regulation of epithelial cell migration

23855590

HgeneCAPN7

GO:0097264

self proteolysis

20849418

TgeneACTR2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE811631CAPN7chr3

15288912

+ACTR2chr2

65495891

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000253693ENST00000260641CAPN7chr3

15288912

+ACTR2chr2

65495891

+
5CDS-intronENST00000253693ENST00000476840CAPN7chr3

15288912

+ACTR2chr2

65495891

+
5CDS-intronENST00000253693ENST00000542850CAPN7chr3

15288912

+ACTR2chr2

65495891

+
5CDS-3UTRENST00000253693ENST00000377982CAPN7chr3

15288912

+ACTR2chr2

65495891

+

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FusionProtFeatures for CAPN7_ACTR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPN7

Q9Y6W3

ACTR2

P61160

Calcium-regulated non-lysosomal thiol-protease.{ECO:0000250}. Functions as ATP-binding component of the Arp2/3 complexwhich is involved in regulation of actin polymerization andtogether with an activating nucleation-promoting factor (NPF)mediates the formation of branched actin networks. Seems tocontact the pointed end of the daughter actin filament.{ECO:0000269|PubMed:9000076}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CAPN7_ACTR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAPN7_ACTR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAPN7_ACTR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CAPN7_ACTR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneACTR2C0036341Schizophrenia1PSYGENET