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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 5455

FusionGeneSummary for CAPN1_TNKS1BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPN1_TNKS1BP1
Fusion gene ID: 5455
HgeneTgene
Gene symbol

CAPN1

TNKS1BP1

Gene ID

823

85456

Gene namecalpain 1tankyrase 1 binding protein 1
SynonymsCANP|CANP1|CANPL1|SPG76|muCANP|muCLTAB182
Cytomap

11q13.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptioncalpain-1 catalytic subunitCANP 1calcium-activated neutral proteinase 1calpain 1, (mu/I) large subunitcalpain mu-typecalpain, large polypeptide L1calpain-1 large subunitcell proliferation-inducing gene 30 proteincell proliferation-inducing protein182 kDa tankyrase-1-binding proteintankyrase 1 binding protein 1, 182kDatankyrase 1-binding protein of 182 kDatestis secretory sperm-binding protein Li 206a
Modification date2018052320180522
UniProtAcc

P07384

Q9C0C2

Ensembl transtripts involved in fusion geneENST00000533820, ENST00000533129, 
ENST00000524773, ENST00000279247, 
ENST00000527469, ENST00000527323, 
ENST00000358252, ENST00000532437, 
ENST00000530920, 
Fusion gene scores* DoF score7 X 7 X 6=2946 X 6 X 2=72
# samples 76
** MAII scorelog2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPN1 [Title/Abstract] AND TNKS1BP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAPN1

GO:0006508

proteolysis

2400579|2407243|16411745|21531719

HgeneCAPN1

GO:0050790

regulation of catalytic activity

8954105|9271093

HgeneCAPN1

GO:0097264

self proteolysis

8769305|8954105


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A6B5-01ACAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000533820ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000533820ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000533820ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000533129ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000533129ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000533129ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000524773ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000524773ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000524773ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000279247ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000279247ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000279247ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
3UTR-3CDSENST00000527469ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
3UTR-3CDSENST00000527469ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
3UTR-intronENST00000527469ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000527323ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000527323ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000527323ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-

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FusionProtFeatures for CAPN1_TNKS1BP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPN1

P07384

TNKS1BP1

Q9C0C2

Calcium-regulated non-lysosomal thiol-protease whichcatalyzes limited proteolysis of substrates involved incytoskeletal remodeling and signal transduction.{ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:2400579}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+42299_106152715Calcium bindingNote=1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+42299_106152715Calcium bindingNote=1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+32199_106152715Calcium bindingNote=1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+42299_106152715Calcium bindingNote=1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+42299_106152715Calcium bindingNote=1
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252-8121723_172916571818MotifNuclear localization signal
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437-7111723_172916571553MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422302_333152715Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422598_609152715Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422628_639152715Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422302_333152715Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422598_609152715Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422628_639152715Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321302_333152715Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321598_609152715Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321628_639152715Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422302_333152715Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422598_609152715Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422628_639152715Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422302_333152715Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422598_609152715Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422628_639152715Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422541_576152715DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+42255_354152715DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422585_618152715DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422615_650152715DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422680_714152715DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422541_576152715DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+42255_354152715DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422585_618152715DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422615_650152715DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422680_714152715DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321541_576152715DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+32155_354152715DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321585_618152715DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321615_650152715DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321680_714152715DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422541_576152715DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+42255_354152715DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422585_618152715DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422615_650152715DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422680_714152715DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422541_576152715DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+42255_354152715DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422585_618152715DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422615_650152715DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422680_714152715DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422355_526152715RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422527_542152715RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422543_713152715RegionNote=Domain IV
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422355_526152715RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422527_542152715RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422543_713152715RegionNote=Domain IV
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321355_526152715RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321527_542152715RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321543_713152715RegionNote=Domain IV
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422355_526152715RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422527_542152715RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422543_713152715RegionNote=Domain IV
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422355_526152715RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422527_542152715RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422543_713152715RegionNote=Domain IV
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252-8121010_134016571818Compositional biasNote=Gly-rich
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252-812127_76716571818Compositional biasNote=Pro-rich
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252-8121572_172916571818Compositional biasNote=Arg/Glu/Lys-rich (charged)
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252-8122_10316571818Compositional biasNote=Arg/Glu/Lys/Pro-rich (charged)
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437-7111010_134016571553Compositional biasNote=Gly-rich
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437-711127_76716571553Compositional biasNote=Pro-rich
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437-7111572_172916571553Compositional biasNote=Arg/Glu/Lys-rich (charged)
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437-7112_10316571553Compositional biasNote=Arg/Glu/Lys/Pro-rich (charged)
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252-8121629_163516571818MotifNuclear localization signal
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437-7111629_163516571553MotifNuclear localization signal
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252-8121450_154216571818RegionNote=Tankyrase-binding
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252-812210_157216571818RegionNote=Acidic
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437-7111450_154216571553RegionNote=Tankyrase-binding
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437-711210_157216571553RegionNote=Acidic


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FusionGeneSequence for CAPN1_TNKS1BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CAPN1_ENST00000533820_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

>In-frame_CAPN1_ENST00000533820_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

>In-frame_CAPN1_ENST00000533129_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

>In-frame_CAPN1_ENST00000533129_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

>In-frame_CAPN1_ENST00000524773_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

>In-frame_CAPN1_ENST00000524773_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

>In-frame_CAPN1_ENST00000279247_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

>In-frame_CAPN1_ENST00000279247_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

>In-frame_CAPN1_ENST00000527323_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

>In-frame_CAPN1_ENST00000527323_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_225aa
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CAPN1_ENST00000533820_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG

>In-frame_CAPN1_ENST00000533820_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG

>In-frame_CAPN1_ENST00000533129_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG

>In-frame_CAPN1_ENST00000533129_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG

>In-frame_CAPN1_ENST00000524773_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG

>In-frame_CAPN1_ENST00000524773_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG

>In-frame_CAPN1_ENST00000279247_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG

>In-frame_CAPN1_ENST00000279247_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG

>In-frame_CAPN1_ENST00000527323_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG

>In-frame_CAPN1_ENST00000527323_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_675nt
ATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGC
CATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCC
TTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAA
CTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCC
ATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCAT
TTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAG
CGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CAPN1_ENST00000533820_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_1345nt
GAAAGTCGGGCCGAACGGGGCAGGGACTTACCCAAGGTCACGCAGCGAGCCCGGTCCCCCTGCGTTCCCCGGGGAGCGCTGAGCCGGGAC
GCGGCGGTGGGGTGGGGAAGGGGAGTGGCGCGGCCCTGCGGGGTGAGGCTGCCGTTTGCTGAGTGTCCGGCAGGGGTCTGCTCGCTGCCA
GCCCGGCCCCTCCTCAGAGCAGCTGCCGCAGCCCGAGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAG
TGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGC
GATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCT
CCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCT
GCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACG
GCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGG
CTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTC
CCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCA
CTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCA
GGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCGAACTCCCCCCACACC
TTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCT
CCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACC

>In-frame_CAPN1_ENST00000533820_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_1343nt
GAAAGTCGGGCCGAACGGGGCAGGGACTTACCCAAGGTCACGCAGCGAGCCCGGTCCCCCTGCGTTCCCCGGGGAGCGCTGAGCCGGGAC
GCGGCGGTGGGGTGGGGAAGGGGAGTGGCGCGGCCCTGCGGGGTGAGGCTGCCGTTTGCTGAGTGTCCGGCAGGGGTCTGCTCGCTGCCA
GCCCGGCCCCTCCTCAGAGCAGCTGCCGCAGCCCGAGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAG
TGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGC
GATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCT
CCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCT
GCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACG
GCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGG
CTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTC
CCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCA
CTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCA
GGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCGAACTCCCCCCACACC
TTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCT
CCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACC

>In-frame_CAPN1_ENST00000533129_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_1202nt
CTCTCGCGGAATTGGCCCCCGGCCTGCGGAGGGAGGGGCGGGGAGACACCGTGAGTAAGAGATAGTCAGAGACCGATGTCGGAGGAGATC
ATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATC
AAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCC
CAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCC
CAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACT
CTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTG
CGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGC
AAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAA
GCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCC
CTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTT
ATGCACTTTGTATCACCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTC
CTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTG
ATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGC

>In-frame_CAPN1_ENST00000533129_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_1200nt
CTCTCGCGGAATTGGCCCCCGGCCTGCGGAGGGAGGGGCGGGGAGACACCGTGAGTAAGAGATAGTCAGAGACCGATGTCGGAGGAGATC
ATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATC
AAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCC
CAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCC
CAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACT
CTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTG
CGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGC
AAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAA
GCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCC
CTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTT
ATGCACTTTGTATCACCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTC
CTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTG
ATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGC

>In-frame_CAPN1_ENST00000524773_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_1227nt
TGGCCCCCGGCCTGCGGAGGGAGGGGCGGGGAGACACCGTGAGTAAGAGATAGTCAGAGACCGTGCCGGAGAGATAAGGGAGAGCCGAGA
GGAAGCGGGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGG
CCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCG
TGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCG
TCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCT
CTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGG
CATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTC
CGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGA
AGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCA
GGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCT
GAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTG
GTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTT
ATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTAC

>In-frame_CAPN1_ENST00000524773_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_1225nt
TGGCCCCCGGCCTGCGGAGGGAGGGGCGGGGAGACACCGTGAGTAAGAGATAGTCAGAGACCGTGCCGGAGAGATAAGGGAGAGCCGAGA
GGAAGCGGGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGG
CCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCG
TGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCG
TCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCT
CTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGG
CATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTC
CGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGA
AGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCA
GGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCT
GAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTG
GTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTT
ATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTAC

>In-frame_CAPN1_ENST00000279247_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_1270nt
AAGGAGAGAGGGAGGGCGGAGGGCGGAGGGGCGGCGGGAGGAGGGCGGGGAGGAGCGCTCTTCCTGGTTGGGCCCTGCCCTGAGCTGCCA
CCGGGAAGCCAGCCTCAGGGACTGCAGCGACCCCCAAACACCCCTCCCCCAGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTG
GGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATG
AGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACC
TGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTA
CCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACC
GAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTG
AGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGC
CCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGA
AGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAG
CCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCG
AACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGC
TTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTG
TATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGCCACTTGAAACAATAAATAAAGT

>In-frame_CAPN1_ENST00000279247_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_1268nt
AAGGAGAGAGGGAGGGCGGAGGGCGGAGGGGCGGCGGGAGGAGGGCGGGGAGGAGCGCTCTTCCTGGTTGGGCCCTGCCCTGAGCTGCCA
CCGGGAAGCCAGCCTCAGGGACTGCAGCGACCCCCAAACACCCCTCCCCCAGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTG
GGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATG
AGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACC
TGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTA
CCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACC
GAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTG
AGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGC
CCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGA
AGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAG
CCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCG
AACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGC
TTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTG
TATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGCCACTTGAAACAATAAATAAAGT

>In-frame_CAPN1_ENST00000527323_chr11_64951063_+_TNKS1BP1_ENST00000358252_chr11_57068515_-_1367nt
GGGATCCGGGAAAGGAGAGGTGGCCGGCACGCCTGGGAACTGGGAAATCCCTTTCCTGGATTCACTGGGAGCACCGGGAGGTGGCTGAGA
ACCCTACTTCTGTGAGGGGAGCAGTGAGGCAGGGAAACCCTAGGTTTGGGGATGGATAAGCAGGGGCAGGAGAGCAGAGCTTGCAGGCAG
GAGCCCAGGTTCTAGTCTTGGGAAGGCCTGGGTTCTGAGCAGGCCCATCTGTCCGGCAGGATGTCGGAGGAGATCATCACGCCGGTGTAC
TGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAG
GATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTAC
AAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGAT
GGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTC
CTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGC
TCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTG
GGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAG
AAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACG
GCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCA
CCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCC
TCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGT
GGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGCCACTTGAAACAATAA

>In-frame_CAPN1_ENST00000527323_chr11_64951063_+_TNKS1BP1_ENST00000532437_chr11_57068515_-_1365nt
GGGATCCGGGAAAGGAGAGGTGGCCGGCACGCCTGGGAACTGGGAAATCCCTTTCCTGGATTCACTGGGAGCACCGGGAGGTGGCTGAGA
ACCCTACTTCTGTGAGGGGAGCAGTGAGGCAGGGAAACCCTAGGTTTGGGGATGGATAAGCAGGGGCAGGAGAGCAGAGCTTGCAGGCAG
GAGCCCAGGTTCTAGTCTTGGGAAGGCCTGGGTTCTGAGCAGGCCCATCTGTCCGGCAGGATGTCGGAGGAGATCATCACGCCGGTGTAC
TGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAG
GATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTAC
AAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGAT
GGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTC
CTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGC
TCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTG
GGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAG
AAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACG
GCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCA
CCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCC
TCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGT
GGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGCCACTTGAAACAATAA


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FusionGenePPI for CAPN1_TNKS1BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAPN1PSEN2, CAST, NFKBIA, FANCA, FANCC, PALB2, FANCG, GAS2, CLEC4G, RAD21, ARRB2, SIRT7, HIF1A, ECT2, FN1, VCAM1, ITGA4, PRMT5, SH3BGR, FHL2, TINAGL1, CREG1, ECHS1, NDUFB7, SLIT3, GPT, CTSC, PTGDS, AES, NFE2L1, ACTC1, MYBPC3, ACTN2, DES, COL1A1, VIM, SPTAN1, BAG3, STAT3, HNRNPD, ASS1, BZW2, BCCIP, CNDP2, EIF4E, EIF6, G6PD, GNS, LDHAL6B, PEPD, PFAS, SLC9A3R1, SMEK2, YWHAQ, CASP7, EEF2, GBP2, GINS2, GINS3, GLA, GLS, HSPA9, MVD, RAP1GDS1, RPS6KA1, TP53, NMT1, ATG5, LGALS3, KNG1, FNTB, CAPNS2, ATP6V1A, GSTO1, MAN2A1, EIF2A, HNRNPR, NIT1, SKIV2L2, SYNCRIP, NTRK1, CEP164, KATNA1, CAPNS1, COG1, POLA2, ANKRD17, CARS2, F2R, GRIN2B, FBXL12, MCM2, CD99L2, TRIP12, CD109, CAPN8, CAPN2, NEFM, RP9, NES, KTN1, FNTA, INA, TBC1D22B, ZIC1TNKS1BP1TNKS, TNKS2, SIRT7, TSG101, HNRNPK, DYNC1H1, CBX3, VCP, CSNK2A1, CNOT6L, CNOT6, NLK, RABGEF1, DCTN3, SPC25, SPTBN1, RNF219, MMP7, CAPZA2, CNOT7, WRAP73, AURKA, CCAR1, EIF4G1, NTRK1, IFI16, XPO1, CNOT2, XRCC3, RAB11A, CNOT1, MCM2, CDC5L, RC3H1, CDH1, NANOS2, CNOT11, TOB1, RIBC1, GADD45B, BTRC, NFKB1, G3BP1, HEY1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAPN1_TNKS1BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CAPN1_TNKS1BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAPN1C0025202melanoma1CTD_human
HgeneCAPN1C0029134Optic Neuritis1CTD_human