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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5442

FusionGeneSummary for CAPN12_LGALS7

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPN12_LGALS7
Fusion gene ID: 5442
HgeneTgene
Gene symbol

CAPN12

LGALS7

Gene ID

147968

653499

Gene namecalpain 12galectin 7B
Synonyms-GAL7|Gal-7|HKL-14|LGALS7|PI7
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptioncalpain-12CANP 12calcium-activated neutral proteinase 12galectin-7keratinocyte lectin 14lectin galactoside-binding soluble 7lectin, galactoside-binding, soluble, 7Bp53-induced gene 1 proteinp53-induced protein 1
Modification date2018052320180519
UniProtAcc

Q6ZSI9

P47929

Ensembl transtripts involved in fusion geneENST00000601953, ENST00000328867, 
ENST00000378626, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CAPN12 [Title/Abstract] AND LGALS7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-ZS-A9CF-01ACAPN12chr19

39232417

-LGALS7chr19

39263743

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000601953ENST00000378626CAPN12chr19

39232417

-LGALS7chr19

39263743

-
Frame-shiftENST00000328867ENST00000378626CAPN12chr19

39232417

-LGALS7chr19

39263743

-

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FusionProtFeatures for CAPN12_LGALS7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPN12

Q6ZSI9

LGALS7

P47929

Calcium-regulated non-lysosomal thiol-protease.{ECO:0000250}. Could be involved in cell-cell and/or cell-matrixinteractions necessary for normal growth control. Pro-apoptoticprotein that functions intracellularly upstream of JNK activationand cytochrome c release. {ECO:0000269|PubMed:11706006}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CAPN12_LGALS7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAPN12_LGALS7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAPN12LGALS7USP15, USP38, USP1, WIPI1, INSIG2, TCF3, CDK2, COPS5, ESR1, HECW2, TUBG1, EZH2, SUZ12, HNRNPA1, IFI16, XPO1, MCM2, TUBA3C, LGALS7B, USP4, DPYSL5, DPYSL4, NAMPT, DPYSL2, GAB1, PIK3C3, POLA2, MKS1, VPS13B, APAF1, TUBB3, METTL3, POLE2, ADSS, KLHL8, TUBB8, RHEB, DOCK7, PALD1, TUBA4A, VWA9, MTPAP, PKN2, DDX19B, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAPN12_LGALS7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CAPN12_LGALS7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLGALS7C0007137Squamous cell carcinoma1CTD_human
TgeneLGALS7C0024667Animal Mammary Neoplasms1CTD_human
TgeneLGALS7C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneLGALS7C0026640Mouth Neoplasms1CTD_human