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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5430

FusionGeneSummary for CANX_PLAT

check button Fusion gene summary
Fusion gene informationFusion gene name: CANX_PLAT
Fusion gene ID: 5430
HgeneTgene
Gene symbol

CANX

PLAT

Gene ID

821

5327

Gene namecalnexinplasminogen activator, tissue type
SynonymsCNX|IP90|P90T-PA|TPA
Cytomap

5q35.3

8p11.21

Type of geneprotein-codingprotein-coding
Descriptioncalnexinmajor histocompatibility complex class I antigen-binding protein p88tissue-type plasminogen activatoralteplaseplasminogen/activator kringlereteplaset-plasminogen activator
Modification date2018052220180523
UniProtAcc

P27824

P00750

Ensembl transtripts involved in fusion geneENST00000504734, ENST00000415618, 
ENST00000452673, ENST00000247461, 
ENST00000512607, ENST00000503126, 
ENST00000270189, ENST00000429089, 
ENST00000220809, ENST00000352041, 
ENST00000519510, ENST00000429710, 
ENST00000524009, 
Fusion gene scores* DoF score9 X 11 X 4=39627 X 5 X 11=1485
# samples 1226
** MAII scorelog2(12/396*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/1485*10)=-2.51387940265967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CANX [Title/Abstract] AND PLAT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLAT

GO:0031639

plasminogen activation

12694198|17849409|24196407

TgenePLAT

GO:0045861

negative regulation of proteolysis

1695900


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-AK-3444-01ACANXchr5

179157926

+PLATchr8

42051245

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000504734ENST00000270189CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000504734ENST00000429089CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000504734ENST00000220809CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000504734ENST00000352041CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000504734ENST00000519510CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000504734ENST00000429710CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000504734ENST00000524009CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000415618ENST00000270189CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000415618ENST00000429089CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000415618ENST00000220809CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000415618ENST00000352041CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000415618ENST00000519510CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000415618ENST00000429710CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000415618ENST00000524009CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000452673ENST00000270189CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000452673ENST00000429089CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000452673ENST00000220809CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000452673ENST00000352041CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000452673ENST00000519510CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000452673ENST00000429710CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000452673ENST00000524009CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000247461ENST00000270189CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000247461ENST00000429089CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000247461ENST00000220809CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000247461ENST00000352041CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000247461ENST00000519510CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000247461ENST00000429710CANXchr5

179157926

+PLATchr8

42051245

-
5CDS-intronENST00000247461ENST00000524009CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000512607ENST00000270189CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000512607ENST00000429089CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000512607ENST00000220809CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000512607ENST00000352041CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000512607ENST00000519510CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000512607ENST00000429710CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000512607ENST00000524009CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000503126ENST00000270189CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000503126ENST00000429089CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000503126ENST00000220809CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000503126ENST00000352041CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000503126ENST00000519510CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000503126ENST00000429710CANXchr5

179157926

+PLATchr8

42051245

-
intron-intronENST00000503126ENST00000524009CANXchr5

179157926

+PLATchr8

42051245

-

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FusionProtFeatures for CANX_PLAT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CANX

P27824

PLAT

P00750

Calcium-binding protein that interacts with newlysynthesized glycoproteins in the endoplasmic reticulum. It may actin assisting protein assembly and/or in the retention within theER of unassembled protein subunits. It seems to play a major rolein the quality control apparatus of the ER by the retention ofincorrectly folded proteins. Associated with partial T-cellantigen receptor complexes that escape the ER of immaturethymocytes, it may function as a signaling complex regulatingthymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CANX_PLAT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CANX_PLAT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CANXLRP1, APOB, EDEM1, PIGK, LCT, CALR, CD1D, EBI3, CD3D, ITGB1, F8, TF, SLC6A4, TSHR, SLC2A1, SLC4A1, LPA, SVIP, BSCL2, ZNRF4, HDAC5, AMFR, L1CAM, NDRG1, ELAVL1, SIRT7, TCF3, UBXN4, CUL3, CAND1, POMP, LMAN1, OPRD1, CHRNA5, CFTR, SERPINF2, KCNH2, BCAP31, UBXN6, TOR1A, PRKCSH, GANAB, RPN2, ASGR1, VCP, PKD2, LDLR, SERPINA1, CSNK2A1, PGRMC1, ATF2, MTNR1A, SMURF2, UBL4A, YIPF3, CLN5, PDIA3, ADRB2, PTGIR, FBXO6, RPA3, RPA2, RPA1, WWOX, NPHS1, LGR4, STAU1, HUWE1, ERLIN2, TRAF6, PMP22, CUL7, CCDC8, SUZ12, RNF2, BMI1, EGFR, FOXRED2, EMC1, PPT1, FAM187B, OGFOD3, POMK, POGLUT1, WNT3A, CHST8, PLTP, CHST9, HNRNPA1, ABCC1, ABCC3, ATP13A1, ACADM, APMAP, ATL3, ATP1B1, ATP2B1, ATP2B3, ATP2B4, CCT4, DARS, DDOST, DNAJA1, EPRS, HSP90AA1, KPNA3, KPNA4, PDIA6, PPP2R1A, PTBP1, RAB2A, RPN1, RPS5, SEC61B, SLC25A3, TECR, CCT3, CCT6A, CLTC, COPB1, CYC1, ETFA, HSP90B1, IDH3A, IPO9, KDSR, KPNA2, MOGS, COX2, NCLN, PC, PSMC2, RAB1A, RAB1B, RCN1, SPTAN1, TUFM, UQCRC2, NTRK1, EWSR1, MDM2, TCTN2, TCTN3, TCTN1, CLU, GBA, LNPEP, ATXN3, SLC33A1, CHST15, RFWD3, CHMP4B, EDEM2, ERBB3, ESRRB, GABRA1, U2AF2, GGT1, TMEM258, CDC73, DERL1, PTPRN, ACP5, CD1E, P2RX2, CLEC2D, BRINP2, GXYLT1, NRROS, CHST6, TMEM5, LIPG, HYAL3, ADAM21, UST, CD1B, DPEP3, DNASE2, GABRG2, ADAM30, P2RX5, TMPRSS11B, AMIGO3, IL27RA, MPPE1, CPA5, DCT, ST3GAL2, WNT16, OPCML, GAL3ST1, FUCA2, C12orf49, NCEH1, SMPD1, B3GNT3, CCNJL, AGT, ARSG, FUT9, TOR3A, A4GALT, IGSF6, TRHDE, GPR114, TMPRSS3, SERPINA5, SCNN1D, CHST14, TMED6, WNT7A, ST8SIA3, PTPRA, PTPRE, PTPRO, MTNR1B, COX15, DLST, SDHA, SOAT1, VDAC1, EDEM3, TAP1, TRIM25, RNF185, GRIN1PLATCLEC3B, CALR, PLAU, KRT8, ANXA2, SERPINI1, SERPINA5, F2, SERPINE1, FGA, LRP1, HMGB1, F10, FN1, LAMA1, TERF2, POT1, PDGFC, FGL1, DCN, TMEM25, PTPRK, IFNA14, LAMA3, SERPINB2, SERPING1, SERPINA10, PLA2G10, SERPINB6, SERPINE2, IGFBP1, DEFA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CANX_PLAT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCANXP27824DB00031TenecteplaseCalnexinbiotechapproved
HgeneCANXP27824DB11093Calcium CitrateCalnexinsmall moleculeapproved
HgeneCANXP27824DB11348Calcium PhosphateCalnexinsmall moleculeapproved
HgeneCANXP27824DB00025Antihemophilic factor, human recombinantCalnexinbiotechapproved|investigational
TgenePLATP00750DB01050IbuprofenTissue-type plasminogen activatorsmall moleculeapproved
TgenePLATP00750DB06404Human C1-esterase inhibitorTissue-type plasminogen activatorbiotechapproved
TgenePLATP00750DB00513Aminocaproic AcidTissue-type plasminogen activatorsmall moleculeapproved|investigational
TgenePLATP00750DB01088IloprostTissue-type plasminogen activatorsmall moleculeapproved|investigational
TgenePLATP00750DB09213DexibuprofenTissue-type plasminogen activatorsmall moleculeapproved|investigational
TgenePLATP00750DB09228Conestat alfaTissue-type plasminogen activatorbiotechapproved|investigational
TgenePLATP00750DB00013UrokinaseTissue-type plasminogen activatorbiotechapproved|investigational|withdrawn

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RelatedDiseases for CANX_PLAT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCANXC0151744Myocardial Ischemia1CTD_human
TgenePLATC0038454Cerebrovascular accident59CTD_human
TgenePLATC0027051Myocardial Infarction35CTD_human
TgenePLATC0007786Brain Ischemia25CTD_human
TgenePLATC2937358Cerebral Hemorrhage21CTD_human
TgenePLATC0151699Intracranial Hemorrhages14CTD_human
TgenePLATC0034065Pulmonary Embolism9CTD_human
TgenePLATC0019080Hemorrhage8CTD_human
TgenePLATC0007785Cerebral Infarction6CTD_human
TgenePLATC0040053Thrombosis4CTD_human
TgenePLATC0740392Infarction, Middle Cerebral Artery4CTD_human
TgenePLATC0002994Angioedema3CTD_human
TgenePLATC0010072Coronary Thrombosis3CTD_human
TgenePLATC0042487Venous Thrombosis3CTD_human
TgenePLATC0007781Intracranial Embolism and Thrombosis2CTD_human
TgenePLATC0877172Hematoma, Epidural, Spinal2CTD_human
TgenePLATC0001125Acidosis, Lactic1CTD_human
TgenePLATC0001883Airway Obstruction1CTD_human
TgenePLATC0003537Aphasia1CTD_human
TgenePLATC0003838Arterial Occlusive Diseases1CTD_human
TgenePLATC0004153Atherosclerosis1CTD_human
TgenePLATC0004604Back Pain1CTD_human
TgenePLATC0004610Bacteremia1CTD_human
TgenePLATC0007177Cardiac Tamponade1CTD_human
TgenePLATC0013922Embolism1CTD_human
TgenePLATC0018801Heart failure1CTD_human
TgenePLATC0018946Hematoma, Subdural1CTD_human
TgenePLATC0020538Hypertensive disease1CTD_human
TgenePLATC0020649Hypotension1CTD_human
TgenePLATC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePLATC0024031Low Back Pain1CTD_human
TgenePLATC0025309Meningoencephalitis1CTD_human
TgenePLATC0027746Nerve Degeneration1CTD_human
TgenePLATC0030552Paresis1CTD_human
TgenePLATC0031039Pericardial effusion1CTD_human
TgenePLATC0033975Psychotic Disorders1PSYGENET
TgenePLATC0035126Reperfusion Injury1CTD_human
TgenePLATC0035229Respiratory Insufficiency1CTD_human
TgenePLATC0036341Schizophrenia1PSYGENET
TgenePLATC0036980Shock, Cardiogenic1CTD_human
TgenePLATC0037926Compression of spinal cord1CTD_human
TgenePLATC0040038Thromboembolism1CTD_human
TgenePLATC0085307Embolism and Thrombosis1CTD_human
TgenePLATC0149649Cholesterol Embolism1CTD_human
TgenePLATC0162820Dermatitis, Allergic Contact1CTD_human
TgenePLATC0235032Neurotoxicity Syndromes1CTD_human
TgenePLATC0236733Amphetamine-Related Disorders1CTD_human
TgenePLATC0242184Hypoxia1CTD_human
TgenePLATC0242698Ventricular Dysfunction, Left1CTD_human
TgenePLATC0349204Nonorganic psychosis1PSYGENET
TgenePLATC0740858Substance abuse problem1PSYGENET
TgenePLATC0751895Vasospasm, Intracranial1CTD_human
TgenePLATC0751955Brain Infarction1CTD_human
TgenePLATC0752143Intracranial Thrombosis1CTD_human
TgenePLATC1861172Venous Thromboembolism1CTD_human
TgenePLATC4277682Chemical and Drug Induced Liver Injury1CTD_human