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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5424

FusionGeneSummary for CANX_CANX

check button Fusion gene summary
Fusion gene informationFusion gene name: CANX_CANX
Fusion gene ID: 5424
HgeneTgene
Gene symbol

CANX

CANX

Gene ID

821

821

Gene namecalnexincalnexin
SynonymsCNX|IP90|P90CNX|IP90|P90
Cytomap

5q35.3

5q35.3

Type of geneprotein-codingprotein-coding
Descriptioncalnexinmajor histocompatibility complex class I antigen-binding protein p88calnexinmajor histocompatibility complex class I antigen-binding protein p88
Modification date2018052220180522
UniProtAcc

P27824

P27824

Ensembl transtripts involved in fusion geneENST00000504734, ENST00000415618, 
ENST00000452673, ENST00000247461, 
ENST00000512607, ENST00000503126, 
ENST00000504734, ENST00000415618, 
ENST00000452673, ENST00000247461, 
ENST00000512607, ENST00000503126, 
Fusion gene scores* DoF score9 X 11 X 4=3969 X 12 X 1=108
# samples 1212
** MAII scorelog2(12/396*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/108*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CANX [Title/Abstract] AND CANX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB242580CANXchr5

179157569

-CANXchr5

179157392

+
ChiTaRS3.1CB856751CANXchr5

179143186

-CANXchr5

179156422

-
ChiTaRS3.1AW583198CANXchr5

179156863

+CANXchr5

179156755

-
ChiTaRS3.1AW469973CANXchr5

179157203

-CANXchr5

179157020

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000504734ENST00000504734CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000504734ENST00000415618CANXchr5

179157569

-CANXchr5

179157392

+
intron-3UTRENST00000504734ENST00000452673CANXchr5

179157569

-CANXchr5

179157392

+
intron-3UTRENST00000504734ENST00000247461CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000504734ENST00000512607CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000504734ENST00000503126CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000415618ENST00000504734CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000415618ENST00000415618CANXchr5

179157569

-CANXchr5

179157392

+
intron-3UTRENST00000415618ENST00000452673CANXchr5

179157569

-CANXchr5

179157392

+
intron-3UTRENST00000415618ENST00000247461CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000415618ENST00000512607CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000415618ENST00000503126CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-intronENST00000452673ENST00000504734CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-intronENST00000452673ENST00000415618CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-3UTRENST00000452673ENST00000452673CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-3UTRENST00000452673ENST00000247461CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-intronENST00000452673ENST00000512607CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-intronENST00000452673ENST00000503126CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-intronENST00000247461ENST00000504734CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-intronENST00000247461ENST00000415618CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-3UTRENST00000247461ENST00000452673CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-3UTRENST00000247461ENST00000247461CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-intronENST00000247461ENST00000512607CANXchr5

179157569

-CANXchr5

179157392

+
3UTR-intronENST00000247461ENST00000503126CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000512607ENST00000504734CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000512607ENST00000415618CANXchr5

179157569

-CANXchr5

179157392

+
intron-3UTRENST00000512607ENST00000452673CANXchr5

179157569

-CANXchr5

179157392

+
intron-3UTRENST00000512607ENST00000247461CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000512607ENST00000512607CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000512607ENST00000503126CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000503126ENST00000504734CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000503126ENST00000415618CANXchr5

179157569

-CANXchr5

179157392

+
intron-3UTRENST00000503126ENST00000452673CANXchr5

179157569

-CANXchr5

179157392

+
intron-3UTRENST00000503126ENST00000247461CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000503126ENST00000512607CANXchr5

179157569

-CANXchr5

179157392

+
intron-intronENST00000503126ENST00000503126CANXchr5

179157569

-CANXchr5

179157392

+
5CDS-intronENST00000504734ENST00000504734CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000504734ENST00000415618CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000504734ENST00000452673CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000504734ENST00000247461CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000504734ENST00000512607CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000504734ENST00000503126CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000415618ENST00000504734CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000415618ENST00000415618CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000415618ENST00000452673CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000415618ENST00000247461CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000415618ENST00000512607CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000415618ENST00000503126CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000452673ENST00000504734CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000452673ENST00000415618CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000452673ENST00000452673CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000452673ENST00000247461CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000452673ENST00000512607CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000452673ENST00000503126CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000247461ENST00000504734CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000247461ENST00000415618CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000247461ENST00000452673CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000247461ENST00000247461CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000247461ENST00000512607CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000247461ENST00000503126CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000512607ENST00000504734CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000512607ENST00000415618CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000512607ENST00000452673CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-3UTRENST00000512607ENST00000247461CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000512607ENST00000512607CANXchr5

179143186

-CANXchr5

179156422

-
5CDS-intronENST00000512607ENST00000503126CANXchr5

179143186

-CANXchr5

179156422

-
3UTR-intronENST00000503126ENST00000504734CANXchr5

179143186

-CANXchr5

179156422

-
3UTR-intronENST00000503126ENST00000415618CANXchr5

179143186

-CANXchr5

179156422

-
3UTR-3UTRENST00000503126ENST00000452673CANXchr5

179143186

-CANXchr5

179156422

-
3UTR-3UTRENST00000503126ENST00000247461CANXchr5

179143186

-CANXchr5

179156422

-
3UTR-intronENST00000503126ENST00000512607CANXchr5

179143186

-CANXchr5

179156422

-
3UTR-intronENST00000503126ENST00000503126CANXchr5

179143186

-CANXchr5

179156422

-
intron-intronENST00000504734ENST00000504734CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000504734ENST00000415618CANXchr5

179156863

+CANXchr5

179156755

-
intron-3UTRENST00000504734ENST00000452673CANXchr5

179156863

+CANXchr5

179156755

-
intron-3UTRENST00000504734ENST00000247461CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000504734ENST00000512607CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000504734ENST00000503126CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000415618ENST00000504734CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000415618ENST00000415618CANXchr5

179156863

+CANXchr5

179156755

-
intron-3UTRENST00000415618ENST00000452673CANXchr5

179156863

+CANXchr5

179156755

-
intron-3UTRENST00000415618ENST00000247461CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000415618ENST00000512607CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000415618ENST00000503126CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-intronENST00000452673ENST00000504734CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-intronENST00000452673ENST00000415618CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-3UTRENST00000452673ENST00000452673CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-3UTRENST00000452673ENST00000247461CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-intronENST00000452673ENST00000512607CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-intronENST00000452673ENST00000503126CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-intronENST00000247461ENST00000504734CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-intronENST00000247461ENST00000415618CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-3UTRENST00000247461ENST00000452673CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-3UTRENST00000247461ENST00000247461CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-intronENST00000247461ENST00000512607CANXchr5

179156863

+CANXchr5

179156755

-
3UTR-intronENST00000247461ENST00000503126CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000512607ENST00000504734CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000512607ENST00000415618CANXchr5

179156863

+CANXchr5

179156755

-
intron-3UTRENST00000512607ENST00000452673CANXchr5

179156863

+CANXchr5

179156755

-
intron-3UTRENST00000512607ENST00000247461CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000512607ENST00000512607CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000512607ENST00000503126CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000503126ENST00000504734CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000503126ENST00000415618CANXchr5

179156863

+CANXchr5

179156755

-
intron-3UTRENST00000503126ENST00000452673CANXchr5

179156863

+CANXchr5

179156755

-
intron-3UTRENST00000503126ENST00000247461CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000503126ENST00000512607CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000503126ENST00000503126CANXchr5

179156863

+CANXchr5

179156755

-
intron-intronENST00000504734ENST00000504734CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000504734ENST00000415618CANXchr5

179157203

-CANXchr5

179157020

+
intron-3UTRENST00000504734ENST00000452673CANXchr5

179157203

-CANXchr5

179157020

+
intron-3UTRENST00000504734ENST00000247461CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000504734ENST00000512607CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000504734ENST00000503126CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000415618ENST00000504734CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000415618ENST00000415618CANXchr5

179157203

-CANXchr5

179157020

+
intron-3UTRENST00000415618ENST00000452673CANXchr5

179157203

-CANXchr5

179157020

+
intron-3UTRENST00000415618ENST00000247461CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000415618ENST00000512607CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000415618ENST00000503126CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-intronENST00000452673ENST00000504734CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-intronENST00000452673ENST00000415618CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-3UTRENST00000452673ENST00000452673CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-3UTRENST00000452673ENST00000247461CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-intronENST00000452673ENST00000512607CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-intronENST00000452673ENST00000503126CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-intronENST00000247461ENST00000504734CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-intronENST00000247461ENST00000415618CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-3UTRENST00000247461ENST00000452673CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-3UTRENST00000247461ENST00000247461CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-intronENST00000247461ENST00000512607CANXchr5

179157203

-CANXchr5

179157020

+
3UTR-intronENST00000247461ENST00000503126CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000512607ENST00000504734CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000512607ENST00000415618CANXchr5

179157203

-CANXchr5

179157020

+
intron-3UTRENST00000512607ENST00000452673CANXchr5

179157203

-CANXchr5

179157020

+
intron-3UTRENST00000512607ENST00000247461CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000512607ENST00000512607CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000512607ENST00000503126CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000503126ENST00000504734CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000503126ENST00000415618CANXchr5

179157203

-CANXchr5

179157020

+
intron-3UTRENST00000503126ENST00000452673CANXchr5

179157203

-CANXchr5

179157020

+
intron-3UTRENST00000503126ENST00000247461CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000503126ENST00000512607CANXchr5

179157203

-CANXchr5

179157020

+
intron-intronENST00000503126ENST00000503126CANXchr5

179157203

-CANXchr5

179157020

+

Top

FusionProtFeatures for CANX_CANX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CANX

P27824

CANX

P27824

Calcium-binding protein that interacts with newlysynthesized glycoproteins in the endoplasmic reticulum. It may actin assisting protein assembly and/or in the retention within theER of unassembled protein subunits. It seems to play a major rolein the quality control apparatus of the ER by the retention ofincorrectly folded proteins. Associated with partial T-cellantigen receptor complexes that escape the ER of immaturethymocytes, it may function as a signaling complex regulatingthymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. Calcium-binding protein that interacts with newlysynthesized glycoproteins in the endoplasmic reticulum. It may actin assisting protein assembly and/or in the retention within theER of unassembled protein subunits. It seems to play a major rolein the quality control apparatus of the ER by the retention ofincorrectly folded proteins. Associated with partial T-cellantigen receptor complexes that escape the ER of immaturethymocytes, it may function as a signaling complex regulatingthymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CANX_CANX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CANX_CANX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CANX_CANX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCANXP27824DB00031TenecteplaseCalnexinbiotechapproved
HgeneCANXP27824DB11093Calcium CitrateCalnexinsmall moleculeapproved
HgeneCANXP27824DB11348Calcium PhosphateCalnexinsmall moleculeapproved
HgeneCANXP27824DB00025Antihemophilic factor, human recombinantCalnexinbiotechapproved|investigational
TgeneCANXP27824DB00031TenecteplaseCalnexinbiotechapproved
TgeneCANXP27824DB11093Calcium CitrateCalnexinsmall moleculeapproved
TgeneCANXP27824DB11348Calcium PhosphateCalnexinsmall moleculeapproved
TgeneCANXP27824DB00025Antihemophilic factor, human recombinantCalnexinbiotechapproved|investigational

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RelatedDiseases for CANX_CANX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCANXC0151744Myocardial Ischemia1CTD_human
TgeneCANXC0151744Myocardial Ischemia1CTD_human