FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5376

FusionGeneSummary for CAMKK2_KCNK5

check button Fusion gene summary
Fusion gene informationFusion gene name: CAMKK2_KCNK5
Fusion gene ID: 5376
HgeneTgene
Gene symbol

CAMKK2

KCNK5

Gene ID

10645

8645

Gene namecalcium/calmodulin dependent protein kinase kinase 2potassium two pore domain channel subfamily K member 5
SynonymsCAMKK|CAMKKBK2p5.1|KCNK5b|TASK-2|TASK2
Cytomap

12q24.31

6p21.2

Type of geneprotein-codingprotein-coding
Descriptioncalcium/calmodulin-dependent protein kinase kinase 2CAMKK beta proteincaM-KK 2caM-KK betacaM-kinase kinase 2caM-kinase kinase betacalcium/calmodulin-dependent protein kinase betacalcium/calmodulin-dependent protein kinase kinase 2, betapotassium channel subfamily K member 5K2P5.1 potassium channelTWIK-related acid-sensitive K(+) channel 2TWIK-related acid-sensitive K+ channel 2acid-sensitive potassium channel protein TASK-2potassium channel, subfamily K, member 1 (TASK-2)potassium
Modification date2018052220180523
UniProtAcc

Q96RR4

O95279

Ensembl transtripts involved in fusion geneENST00000392474, ENST00000538733, 
ENST00000337174, ENST00000347034, 
ENST00000324774, ENST00000545538, 
ENST00000412367, ENST00000404169, 
ENST00000402834, ENST00000446440, 
ENST00000392473, ENST00000535524, 
ENST00000359534, 
Fusion gene scores* DoF score8 X 9 X 9=6481 X 1 X 1=1
# samples 151
** MAII scorelog2(15/648*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CAMKK2 [Title/Abstract] AND KCNK5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAMKK2

GO:0006468

protein phosphorylation

11395482

HgeneCAMKK2

GO:0046777

protein autophosphorylation

11395482


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM836721CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000392474ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000538733ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000337174ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000347034ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000324774ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000545538ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000412367ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000404169ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000402834ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000446440ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000392473ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-
intron-5UTRENST00000535524ENST00000359534CAMKK2chr12

121677140

-KCNK5chr6

39197059

-

Top

FusionProtFeatures for CAMKK2_KCNK5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAMKK2

Q96RR4

KCNK5

O95279

pH-dependent, voltage insensitive, outwardly rectifyingpotassium channel. Outward rectification is lost at high externalK(+) concentrations.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CAMKK2_KCNK5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CAMKK2_KCNK5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CAMKK2_KCNK5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CAMKK2_KCNK5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAMKK2C0036341Schizophrenia1PSYGENET
TgeneKCNK5C0038220Status Epilepticus1CTD_human