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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5329

FusionGeneSummary for CALR_MCM3

check button Fusion gene summary
Fusion gene informationFusion gene name: CALR_MCM3
Fusion gene ID: 5329
HgeneTgene
Gene symbol

CALR

MCM3

Gene ID

811

4172

Gene namecalreticulinminichromosome maintenance complex component 3
SynonymsCRT|HEL-S-99n|RO|SSA|cC1qRHCC5|P1-MCM3|P1.h|RLFB
Cytomap

19p13.13

6p12.2

Type of geneprotein-codingprotein-coding
DescriptioncalreticulinCRP55ERp60HACBPSicca syndrome antigen A (autoantigen Ro; calreticulin)calregulinendoplasmic reticulum resident protein 60epididymis secretory sperm binding protein Li 99ngrp60DNA replication licensing factor MCM3DNA polymerase alpha holoenzyme-associated protein P1DNA replication factor MCM3MCM3 minichromosome maintenance deficient 3RLF subunit betacervical cancer proto-oncogene 5hRlf beta subunitminichromosome maintena
Modification date2018052720180519
UniProtAcc

P27797

P25205

Ensembl transtripts involved in fusion geneENST00000316448, ENST00000229854, 
ENST00000596288, ENST00000419835, 
ENST00000476448, 
Fusion gene scores* DoF score7 X 9 X 5=3153 X 3 X 2=18
# samples 123
** MAII scorelog2(12/315*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CALR [Title/Abstract] AND MCM3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCALR

GO:0000122

negative regulation of transcription by RNA polymerase II

8107809

HgeneCALR

GO:0006611

protein export from nucleus

11149926

HgeneCALR

GO:0017148

negative regulation of translation

14726956

HgeneCALR

GO:0033144

negative regulation of intracellular steroid hormone receptor signaling pathway

8107809

HgeneCALR

GO:0034504

protein localization to nucleus

15998798

HgeneCALR

GO:0045665

negative regulation of neuron differentiation

8107809

HgeneCALR

GO:0045892

negative regulation of transcription, DNA-templated

8107809

HgeneCALR

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

8107809


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE837730CALRchr19

13051121

+MCM3chr6

52137249

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000316448ENST00000229854CALRchr19

13051121

+MCM3chr6

52137249

-
Frame-shiftENST00000316448ENST00000596288CALRchr19

13051121

+MCM3chr6

52137249

-
Frame-shiftENST00000316448ENST00000419835CALRchr19

13051121

+MCM3chr6

52137249

-
5CDS-intronENST00000316448ENST00000476448CALRchr19

13051121

+MCM3chr6

52137249

-

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FusionProtFeatures for CALR_MCM3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALR

P27797

MCM3

P25205

Calcium-binding chaperone that promotes folding,oligomeric assembly and quality control in the endoplasmicreticulum (ER) via the calreticulin/calnexin cycle. This lectininteracts transiently with almost all of the monoglucosylatedglycoproteins that are synthesized in the ER. Interacts with theDNA-binding domain of NR3C1 and mediates its nuclear export.Involved in maternal gene expression regulation. May participatein oocyte maturation via the regulation of calcium homeostasis (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:11149926,ECO:0000269|PubMed:7876246}. Acts as component of the MCM2-7 complex (MCM complex)which is the putative replicative helicase essential for 'once percell cycle' DNA replication initiation and elongation ineukaryotic cells. The active ATPase sites in the MCM2-7 ring areformed through the interaction surfaces of two neighboringsubunits such that a critical structure of a conserved argininefinger motif is provided in trans relative to the ATP-binding siteof the Walker A box of the adjacent subunit. The six ATPase activesites, however, are likely to contribute differentially to thecomplex helicase activity. Required for DNA replication and cellproliferation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CALR_MCM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CALR_MCM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CALR_MCM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCALRP27797DB00031TenecteplaseCalreticulinbiotechapproved
HgeneCALRP27797DB11093Calcium CitrateCalreticulinsmall moleculeapproved
HgeneCALRP27797DB11348Calcium PhosphateCalreticulinsmall moleculeapproved
HgeneCALRP27797DB00025Antihemophilic factor, human recombinantCalreticulinbiotechapproved|investigational
HgeneCALRP27797DB01065MelatoninCalreticulinsmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for CALR_MCM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCALRC0033975Psychotic Disorders2PSYGENET
HgeneCALRC0036337Schizoaffective Disorder2PSYGENET
HgeneCALRC0349204Nonorganic psychosis2PSYGENET
HgeneCALRC0005586Bipolar Disorder1PSYGENET
HgeneCALRC0009404Colorectal Neoplasms1CTD_human
HgeneCALRC0025205Melanoma, Experimental1CTD_human
HgeneCALRC0027626Neoplasm Invasiveness1CTD_human
HgeneCALRC0033578Prostatic Neoplasms1CTD_human
HgeneCALRC0033937Psychoses, Drug1PSYGENET
HgeneCALRC0036349Paranoid Schizophrenia1PSYGENET
HgeneCALRC0036939Shared Paranoid Disorder1PSYGENET
HgeneCALRC0151744Myocardial Ischemia1CTD_human
HgeneCALRC0279626Squamous cell carcinoma of esophagus1CTD_human