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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5323

FusionGeneSummary for CALN1_IFNAR1

check button Fusion gene summary
Fusion gene informationFusion gene name: CALN1_IFNAR1
Fusion gene ID: 5323
HgeneTgene
Gene symbol

CALN1

IFNAR1

Gene ID

83698

3454

Gene namecalneuron 1interferon alpha and beta receptor subunit 1
SynonymsCABP8AVP|IFN-alpha-REC|IFNAR|IFNBR|IFRC
Cytomap

7q11.22

21q22.11

Type of geneprotein-codingprotein-coding
Descriptioncalcium-binding protein 8calcium-binding protein CABP8calneuron Iinterferon alpha/beta receptor 1CRF2-1IFN-R-1IFN-alpha/beta receptor 1alpha-type antiviral proteinbeta-type antiviral proteincytokine receptor class-II member 1cytokine receptor family 2 member 1interferon (alpha, beta and omega) receptor 1interf
Modification date2018051920180523
UniProtAcc

Q9BXU9

P17181

Ensembl transtripts involved in fusion geneENST00000329008, ENST00000395275, 
ENST00000395276, ENST00000405452, 
ENST00000412588, ENST00000431984, 
ENST00000416947, ENST00000493503, 
ENST00000270139, ENST00000442357, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 2=50
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/50*10)=0
Context

PubMed: CALN1 [Title/Abstract] AND IFNAR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIFNAR1

GO:0060337

type I interferon signaling pathway

7665574


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE005671CALN1chr7

71633831

-IFNAR1chr21

34728281

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000329008ENST00000416947CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000329008ENST00000493503CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-3UTRENST00000329008ENST00000270139CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000329008ENST00000442357CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000395275ENST00000416947CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000395275ENST00000493503CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-3UTRENST00000395275ENST00000270139CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000395275ENST00000442357CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000395276ENST00000416947CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000395276ENST00000493503CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-3UTRENST00000395276ENST00000270139CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000395276ENST00000442357CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000405452ENST00000416947CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000405452ENST00000493503CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-3UTRENST00000405452ENST00000270139CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000405452ENST00000442357CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000412588ENST00000416947CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000412588ENST00000493503CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-3UTRENST00000412588ENST00000270139CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000412588ENST00000442357CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000431984ENST00000416947CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000431984ENST00000493503CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-3UTRENST00000431984ENST00000270139CALN1chr7

71633831

-IFNAR1chr21

34728281

+
intron-intronENST00000431984ENST00000442357CALN1chr7

71633831

-IFNAR1chr21

34728281

+

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FusionProtFeatures for CALN1_IFNAR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALN1

Q9BXU9

IFNAR1

P17181

Negatively regulates Golgi-to-plasma membranetrafficking by interacting with PI4KB and inhibiting its activity(By similarity). May play a role in the physiology of neurons andis potentially important in memory and learning. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CALN1_IFNAR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CALN1_IFNAR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CALN1_IFNAR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIFNAR1P17181DB00022Peginterferon alfa-2bInterferon alpha/beta receptor 1biotechapproved
TgeneIFNAR1P17181DB00068Interferon beta-1bInterferon alpha/beta receptor 1biotechapproved
TgeneIFNAR1P17181DB00105Interferon Alfa-2b, RecombinantInterferon alpha/beta receptor 1biotechapproved
TgeneIFNAR1P17181DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 1biotechapproved|investigational
TgeneIFNAR1P17181DB00011Interferon alfa-n1Interferon alpha/beta receptor 1biotechapproved|investigational
TgeneIFNAR1P17181DB00034Interferon Alfa-2a, RecombinantInterferon alpha/beta receptor 1biotechapproved|investigational
TgeneIFNAR1P17181DB00060Interferon beta-1aInterferon alpha/beta receptor 1biotechapproved|investigational
TgeneIFNAR1P17181DB00069Interferon alfacon-1Interferon alpha/beta receptor 1biotechapproved|investigational

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RelatedDiseases for CALN1_IFNAR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIFNAR1C0042769Virus Diseases1CTD_human
TgeneIFNAR1C0086132Depressive Symptoms1PSYGENET
TgeneIFNAR1C0338715Drug-induced depressive state1PSYGENET