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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5318

FusionGeneSummary for CALM3_TROVE2

check button Fusion gene summary
Fusion gene informationFusion gene name: CALM3_TROVE2
Fusion gene ID: 5318
HgeneTgene
Gene symbol

CALM3

TROVE2

Gene ID

808

6738

Gene namecalmodulin 3TROVE domain family member 2
SynonymsCaM|CaMIII|HEL-S-72|PHKD|PHKD3RO60|RORNP|SSA2
Cytomap

19q13.32

1q31.2

Type of geneprotein-codingprotein-coding
Descriptioncalmodulin-3epididymis secretory protein Li 72phosphorylase kinase subunit deltaprepro-calmodulin 360 kDa SS-A/Ro ribonucleoprotein60 kDa ribonucleoprotein RoSjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro)gastric cancer multi-drug resistance proteinsjoegren syndrome type A antigen
Modification date2018052320180519
UniProtAcc

P10155

Ensembl transtripts involved in fusion geneENST00000391918, ENST00000291295, 
ENST00000597743, ENST00000477244, 
ENST00000598871, ENST00000594523, 
ENST00000599839, ENST00000596362, 
ENST00000400968, ENST00000432079, 
ENST00000460715, ENST00000416058, 
ENST00000367446, ENST00000367445, 
ENST00000367444, ENST00000367443, 
ENST00000367441, 
Fusion gene scores* DoF score8 X 9 X 3=2163 X 3 X 2=18
# samples 114
** MAII scorelog2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CALM3 [Title/Abstract] AND TROVE2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCALM3

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

20226167

HgeneCALM3

GO:0030801

positive regulation of cyclic nucleotide metabolic process

8631777

HgeneCALM3

GO:0032516

positive regulation of phosphoprotein phosphatase activity

8631777

HgeneCALM3

GO:0035307

positive regulation of protein dephosphorylation

8631777

HgeneCALM3

GO:0051343

positive regulation of cyclic-nucleotide phosphodiesterase activity

8631777

HgeneCALM3

GO:0051592

response to calcium ion

7607248

HgeneCALM3

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

20226167


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ327040CALM3chr19

47113184

-TROVE2chr1

193057032

+
ChiTaRS3.1BQ327094CALM3chr19

47113184

-TROVE2chr1

193057032

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000391918ENST00000400968CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-3UTRENST00000391918ENST00000432079CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000391918ENST00000460715CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000391918ENST00000416058CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000391918ENST00000367446CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000391918ENST00000367445CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000391918ENST00000367444CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000391918ENST00000367443CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000391918ENST00000367441CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000291295ENST00000400968CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-3UTRENST00000291295ENST00000432079CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000291295ENST00000460715CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000291295ENST00000416058CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000291295ENST00000367446CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000291295ENST00000367445CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000291295ENST00000367444CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000291295ENST00000367443CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000291295ENST00000367441CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000597743ENST00000400968CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-3UTRENST00000597743ENST00000432079CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000597743ENST00000460715CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000597743ENST00000416058CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000597743ENST00000367446CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000597743ENST00000367445CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000597743ENST00000367444CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000597743ENST00000367443CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000597743ENST00000367441CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000477244ENST00000400968CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-3UTRENST00000477244ENST00000432079CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000477244ENST00000460715CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000477244ENST00000416058CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000477244ENST00000367446CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000477244ENST00000367445CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000477244ENST00000367444CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000477244ENST00000367443CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000477244ENST00000367441CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000598871ENST00000400968CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-3UTRENST00000598871ENST00000432079CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000598871ENST00000460715CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000598871ENST00000416058CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000598871ENST00000367446CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000598871ENST00000367445CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000598871ENST00000367444CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000598871ENST00000367443CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000598871ENST00000367441CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000594523ENST00000400968CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-3UTRENST00000594523ENST00000432079CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000594523ENST00000460715CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000594523ENST00000416058CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000594523ENST00000367446CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000594523ENST00000367445CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000594523ENST00000367444CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000594523ENST00000367443CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000594523ENST00000367441CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000599839ENST00000400968CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-3UTRENST00000599839ENST00000432079CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000599839ENST00000460715CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000599839ENST00000416058CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000599839ENST00000367446CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000599839ENST00000367445CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000599839ENST00000367444CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000599839ENST00000367443CALM3chr19

47113184

-TROVE2chr1

193057032

+
3UTR-intronENST00000599839ENST00000367441CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000596362ENST00000400968CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-3UTRENST00000596362ENST00000432079CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000596362ENST00000460715CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000596362ENST00000416058CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000596362ENST00000367446CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000596362ENST00000367445CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000596362ENST00000367444CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000596362ENST00000367443CALM3chr19

47113184

-TROVE2chr1

193057032

+
intron-intronENST00000596362ENST00000367441CALM3chr19

47113184

-TROVE2chr1

193057032

+

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FusionProtFeatures for CALM3_TROVE2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALM3

TROVE2

P10155

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CALM3_TROVE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CALM3_TROVE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CALM3_TROVE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CALM3_TROVE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource