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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5307

FusionGeneSummary for CALM1_RALA

check button Fusion gene summary
Fusion gene informationFusion gene name: CALM1_RALA
Fusion gene ID: 5307
HgeneTgene
Gene symbol

CALM1

RALA

Gene ID

801

5898

Gene namecalmodulin 1RAS like proto-oncogene A
SynonymsCALML2|CAMI|CPVT4|DD132|LQT14|PHKD|caMRAL
Cytomap

14q32.11

7p14.1

Type of geneprotein-codingprotein-coding
Descriptioncalmodulin-1calmodulin 1 (phosphorylase kinase, delta)phosphorylase kinase subunit deltaphosphorylase kinase, delta subunitprepro-calmodulin 1ras-related protein Ral-ARALA Ras like proto-oncogene ARAS-like protein ARas family small GTP binding protein RALAras related GTP binding protein Av-ral simian leukemia viral oncogene homolog A (ras related)
Modification date2018052920180519
UniProtAcc

P11233

Ensembl transtripts involved in fusion geneENST00000356978, ENST00000447653, 
ENST00000555132, ENST00000553542, 
ENST00000544280, 
ENST00000005257, 
ENST00000468201, 
Fusion gene scores* DoF score10 X 10 X 2=2004 X 3 X 4=48
# samples 214
** MAII scorelog2(21/200*10)=0.070389327891398
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALM1 [Title/Abstract] AND RALA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCALM1

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

20226167

HgeneCALM1

GO:0030801

positive regulation of cyclic nucleotide metabolic process

8631777

HgeneCALM1

GO:0032516

positive regulation of phosphoprotein phosphatase activity

8631777

HgeneCALM1

GO:0035307

positive regulation of protein dephosphorylation

8631777

HgeneCALM1

GO:0051343

positive regulation of cyclic-nucleotide phosphodiesterase activity

8631777

HgeneCALM1

GO:0051592

response to calcium ion

7607248

HgeneCALM1

GO:0060314

regulation of ryanodine-sensitive calcium-release channel activity

22067155

HgeneCALM1

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

26164367

HgeneCALM1

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

20226167

TgeneRALA

GO:0017157

regulation of exocytosis

20005108

TgeneRALA

GO:0031532

actin cytoskeleton reorganization

10051605

TgeneRALA

GO:0051491

positive regulation of filopodium assembly

10051605

TgeneRALA

GO:0051665

membrane raft localization

20005108


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD366766CALM1chr14

90870820

-RALAchr7

39745749

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356978ENST00000005257CALM1chr14

90870820

-RALAchr7

39745749

-
5CDS-3UTRENST00000356978ENST00000468201CALM1chr14

90870820

-RALAchr7

39745749

-
Frame-shiftENST00000447653ENST00000005257CALM1chr14

90870820

-RALAchr7

39745749

-
5CDS-3UTRENST00000447653ENST00000468201CALM1chr14

90870820

-RALAchr7

39745749

-
intron-3CDSENST00000555132ENST00000005257CALM1chr14

90870820

-RALAchr7

39745749

-
intron-3UTRENST00000555132ENST00000468201CALM1chr14

90870820

-RALAchr7

39745749

-
Frame-shiftENST00000553542ENST00000005257CALM1chr14

90870820

-RALAchr7

39745749

-
5CDS-3UTRENST00000553542ENST00000468201CALM1chr14

90870820

-RALAchr7

39745749

-
Frame-shiftENST00000544280ENST00000005257CALM1chr14

90870820

-RALAchr7

39745749

-
5CDS-3UTRENST00000544280ENST00000468201CALM1chr14

90870820

-RALAchr7

39745749

-

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FusionProtFeatures for CALM1_RALA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALM1

RALA

P11233

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Multifunctional GTPase involved in a variety of cellularprocesses including gene expression, cell migration, cellproliferation, oncogenic transformation and membrane trafficking.Accomplishes its multiple functions by interacting with distinctdownstream effectors. Acts as a GTP sensor for GTP-dependentexocytosis of dense core vesicles. The RALA-exocyst complexregulates integrin-dependent membrane raft exocytosis and growthsignaling (PubMed:20005108). Key regulator of LPAR1 signaling andcompetes with GRK2 for binding to LPAR1 thus affecting thesignaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925).During mitosis, supports the stabilization and elongation of theintracellular bridge between dividing cells. Cooperates with EXOC2to recruit other components of the exocyst to the early midbody(PubMed:18756269). {ECO:0000269|PubMed:18756269,ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CALM1_RALA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CALM1_RALA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CALM1_RALA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CALM1_RALA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCALM1C3554047VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 42UNIPROT
HgeneCALM1C4015671LONG QT SYNDROME 142UNIPROT
HgeneCALM1C4015695LONG QT SYNDROME 152UNIPROT
HgeneCALM1C0002395Alzheimer's Disease1CTD_human
HgeneCALM1C0024809Marijuana Abuse1CTD_human
HgeneCALM1C0031391Phencyclidine Abuse1CTD_human
HgeneCALM1C0036341Schizophrenia1PSYGENET
HgeneCALM1C0043094Weight Gain1CTD_human
HgeneCALM1C0236736Cocaine-Related Disorders1CTD_human