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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5306

FusionGeneSummary for CALM1_PSME3

check button Fusion gene summary
Fusion gene informationFusion gene name: CALM1_PSME3
Fusion gene ID: 5306
HgeneTgene
Gene symbol

CALM1

PSME3

Gene ID

801

10197

Gene namecalmodulin 1proteasome activator subunit 3
SynonymsCALML2|CAMI|CPVT4|DD132|LQT14|PHKD|caMHEL-S-283|Ki|PA28-gamma|PA28G|PA28gamma|REG-GAMMA
Cytomap

14q32.11

17q21.31

Type of geneprotein-codingprotein-coding
Descriptioncalmodulin-1calmodulin 1 (phosphorylase kinase, delta)phosphorylase kinase subunit deltaphosphorylase kinase, delta subunitprepro-calmodulin 1proteasome activator complex subunit 311S regulator complex gamma subunit11S regulator complex subunit gammaKi antigenKi nuclear autoantigenPA28 gamma variant 5REG gamma-3activator of multicatalytic protease subunit 3epididymis secretory protein L
Modification date2018052920180523
UniProtAcc

P61289

Ensembl transtripts involved in fusion geneENST00000356978, ENST00000447653, 
ENST00000555132, ENST00000553542, 
ENST00000544280, 		ENST00000545225, 
ENST00000590720, ENST00000541124, 
ENST00000592578, ENST00000441946, 
ENST00000293362, ENST00000592169, 
Fusion gene scores* DoF score10 X 10 X 2=2003 X 3 X 2=18
# samples 214
** MAII scorelog2(21/200*10)=0.070389327891398
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CALM1 [Title/Abstract] AND PSME3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCALM1

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

20226167

HgeneCALM1

GO:0030801

positive regulation of cyclic nucleotide metabolic process

8631777

HgeneCALM1

GO:0032516

positive regulation of phosphoprotein phosphatase activity

8631777

HgeneCALM1

GO:0035307

positive regulation of protein dephosphorylation

8631777

HgeneCALM1

GO:0051343

positive regulation of cyclic-nucleotide phosphodiesterase activity

8631777

HgeneCALM1

GO:0051592

response to calcium ion

7607248

HgeneCALM1

GO:0060314

regulation of ryanodine-sensitive calcium-release channel activity

22067155

HgeneCALM1

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

26164367

HgeneCALM1

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

20226167

TgenePSME3

GO:0061136

regulation of proteasomal protein catabolic process

18309296

TgenePSME3

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

18309296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF218294CALM1chr14

90872488

+PSME3chr17

40995163

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000356978ENST00000545225CALM1chr14

90872488

+PSME3chr17

40995163

+
3UTR-intronENST00000356978ENST00000590720CALM1chr14

90872488

+PSME3chr17

40995163

+
3UTR-3UTRENST00000356978ENST00000541124CALM1chr14

90872488

+PSME3chr17

40995163

+
3UTR-intronENST00000356978ENST00000592578CALM1chr14

90872488

+PSME3chr17

40995163

+
3UTR-3UTRENST00000356978ENST00000441946CALM1chr14

90872488

+PSME3chr17

40995163

+
3UTR-3UTRENST00000356978ENST00000293362CALM1chr14

90872488

+PSME3chr17

40995163

+
3UTR-intronENST00000356978ENST00000592169CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000447653ENST00000545225CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000447653ENST00000590720CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000447653ENST00000541124CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000447653ENST00000592578CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000447653ENST00000441946CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000447653ENST00000293362CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000447653ENST00000592169CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000555132ENST00000545225CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000555132ENST00000590720CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000555132ENST00000541124CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000555132ENST00000592578CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000555132ENST00000441946CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000555132ENST00000293362CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000555132ENST00000592169CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000553542ENST00000545225CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000553542ENST00000590720CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000553542ENST00000541124CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000553542ENST00000592578CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000553542ENST00000441946CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000553542ENST00000293362CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000553542ENST00000592169CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000544280ENST00000545225CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000544280ENST00000590720CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000544280ENST00000541124CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000544280ENST00000592578CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000544280ENST00000441946CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-3UTRENST00000544280ENST00000293362CALM1chr14

90872488

+PSME3chr17

40995163

+
intron-intronENST00000544280ENST00000592169CALM1chr14

90872488

+PSME3chr17

40995163

+

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FusionProtFeatures for CALM1_PSME3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALM1

PSME3

P61289

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Subunit of the 11S REG-gamma (also called PA28-gamma)proteasome regulator, a doughnut-shaped homoheptamer whichassociates with the proteasome. 11S REG-gamma activates thetrypsin-like catalytic subunit of the proteasome but inhibits thechymotrypsin-like and postglutamyl-preferring (PGPH) subunits.Facilitates the MDM2-p53/TP53 interaction which promotesubiquitination- and MDM2-dependent proteasomal degradation ofp53/TP53, limiting its accumulation and resulting in inhibitedapoptosis after DNA damage. May also be involved in cell cycleregulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition(PubMed:25361978). {ECO:0000269|PubMed:10835274,ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824,ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296,ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CALM1_PSME3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CALM1_PSME3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CALM1_PSME3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CALM1_PSME3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCALM1C3554047VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 42UNIPROT
HgeneCALM1C4015671LONG QT SYNDROME 142UNIPROT
HgeneCALM1C4015695LONG QT SYNDROME 152UNIPROT
HgeneCALM1C0002395Alzheimer's Disease1CTD_human
HgeneCALM1C0024809Marijuana Abuse1CTD_human
HgeneCALM1C0031391Phencyclidine Abuse1CTD_human
HgeneCALM1C0036341Schizophrenia1PSYGENET
HgeneCALM1C0043094Weight Gain1CTD_human
HgeneCALM1C0236736Cocaine-Related Disorders1CTD_human
TgenePSME3C0019693HIV Infections1CTD_human