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Fusion gene ID: 5304 |
FusionGeneSummary for CALM1_MGP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CALM1_MGP | Fusion gene ID: 5304 | Hgene | Tgene | Gene symbol | CALM1 | MGP | Gene ID | 801 | 4256 |
| Gene name | calmodulin 1 | matrix Gla protein | |
| Synonyms | CALML2|CAMI|CPVT4|DD132|LQT14|PHKD|caM | GIG36|MGLAP|NTI | |
| Cytomap | 14q32.11 | 12p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calmodulin-1calmodulin 1 (phosphorylase kinase, delta)phosphorylase kinase subunit deltaphosphorylase kinase, delta subunitprepro-calmodulin 1 | matrix Gla proteincell growth-inhibiting gene 36 protein | |
| Modification date | 20180529 | 20180527 | |
| UniProtAcc | P08493 | ||
| Ensembl transtripts involved in fusion gene | ENST00000356978, ENST00000447653, ENST00000555132, ENST00000553542, ENST00000544280, | ENST00000539261, ENST00000228938, | |
| Fusion gene scores | * DoF score | 10 X 10 X 2=200 | 10 X 7 X 2=140 |
| # samples | 21 | 18 | |
| ** MAII score | log2(21/200*10)=0.070389327891398 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(18/140*10)=0.362570079384708 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CALM1 [Title/Abstract] AND MGP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CALM1 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 20226167 |
| Hgene | CALM1 | GO:0030801 | positive regulation of cyclic nucleotide metabolic process | 8631777 |
| Hgene | CALM1 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 8631777 |
| Hgene | CALM1 | GO:0035307 | positive regulation of protein dephosphorylation | 8631777 |
| Hgene | CALM1 | GO:0051343 | positive regulation of cyclic-nucleotide phosphodiesterase activity | 8631777 |
| Hgene | CALM1 | GO:0051592 | response to calcium ion | 7607248 |
| Hgene | CALM1 | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 22067155 |
| Hgene | CALM1 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 26164367 |
| Hgene | CALM1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 20226167 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE813514 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - | ||
| ChiTaRS3.1 | AW993959 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - | ||
| ChiTaRS3.1 | BE813702 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - | ||
| ChiTaRS3.1 | AW993976 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - | ||
| ChiTaRS3.1 | BE813534 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - | ||
| ChiTaRS3.1 | AW993963 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - | ||
| ChiTaRS3.1 | AW993962 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - | ||
| ChiTaRS3.1 | AW993965 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - | ||
| ChiTaRS3.1 | BE813679 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000356978 | ENST00000539261 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| 3UTR-3UTR | ENST00000356978 | ENST00000228938 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| intron-3UTR | ENST00000447653 | ENST00000539261 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| intron-3UTR | ENST00000447653 | ENST00000228938 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| intron-3UTR | ENST00000555132 | ENST00000539261 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| intron-3UTR | ENST00000555132 | ENST00000228938 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| intron-3UTR | ENST00000553542 | ENST00000539261 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| intron-3UTR | ENST00000553542 | ENST00000228938 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| intron-3UTR | ENST00000544280 | ENST00000539261 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
| intron-3UTR | ENST00000544280 | ENST00000228938 | CALM1 | chr14 | 90874245 | + | MGP | chr12 | 15035035 | - |
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FusionProtFeatures for CALM1_MGP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CALM1 | MGP |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Associates with the organic matrix of bone andcartilage. Thought to act as an inhibitor of bone formation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CALM1_MGP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CALM1_MGP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CALM1_MGP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MGP | P08493 | DB01373 | Calcium | Matrix Gla protein | small molecule | approved|nutraceutical |
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RelatedDiseases for CALM1_MGP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CALM1 | C3554047 | VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 4 | 2 | UNIPROT |
| Hgene | CALM1 | C4015671 | LONG QT SYNDROME 14 | 2 | UNIPROT |
| Hgene | CALM1 | C4015695 | LONG QT SYNDROME 15 | 2 | UNIPROT |
| Hgene | CALM1 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Hgene | CALM1 | C0024809 | Marijuana Abuse | 1 | CTD_human |
| Hgene | CALM1 | C0031391 | Phencyclidine Abuse | 1 | CTD_human |
| Hgene | CALM1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | CALM1 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | CALM1 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | MGP | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Tgene | MGP | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
| Tgene | MGP | C0000786 | Spontaneous abortion | 1 | CTD_human;HPO |
| Tgene | MGP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | MGP | C0041948 | Uremia | 1 | CTD_human |
| Tgene | MGP | C0042345 | Varicosity | 1 | CTD_human |
| Tgene | MGP | C0342649 | Vascular calcification | 1 | CTD_human |
| Tgene | MGP | C1855607 | Keutel syndrome | 1 | CTD_human;ORPHANET |
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