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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5291

FusionGeneSummary for CALD1_EXOC4

check button Fusion gene summary
Fusion gene informationFusion gene name: CALD1_EXOC4
Fusion gene ID: 5291
HgeneTgene
Gene symbol

CALD1

EXOC4

Gene ID

800

60412

Gene namecaldesmon 1exocyst complex component 4
SynonymsCDM|H-CAD|HCAD|L-CAD|LCAD|NAG22SEC8|SEC8L1|Sec8p
Cytomap

7q33

7q33

Type of geneprotein-codingprotein-coding
Descriptioncaldesmontestis secretory sperm-binding protein Li 227nexocyst complex component 4SEC8-like 1exocyst complex component Sec8
Modification date2018052220180523
UniProtAcc

Q05682

Q96A65

Ensembl transtripts involved in fusion geneENST00000417172, ENST00000361388, 
ENST00000422748, ENST00000361675, 
ENST00000361901, ENST00000393118, 
ENST00000495522, ENST00000424922, 
ENST00000543443, ENST00000466704, 
ENST00000253861, ENST00000539845, 
ENST00000393161, ENST00000545148, 
ENST00000460346, ENST00000541309, 
Fusion gene scores* DoF score14 X 16 X 9=201615 X 12 X 7=1260
# samples 2015
** MAII scorelog2(20/2016*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1260*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALD1 [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GV-A40E-01ACALD1chr7

134464500

+EXOC4chr7

133749044

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000417172ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000417172ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000417172ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000417172ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000417172ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000417172ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-3CDSENST00000361388ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-3CDSENST00000361388ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361388ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361388ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361388ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361388ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-3CDSENST00000422748ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-3CDSENST00000422748ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000422748ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000422748ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000422748ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000422748ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-3CDSENST00000361675ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-3CDSENST00000361675ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361675ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361675ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361675ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361675ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-3CDSENST00000361901ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-3CDSENST00000361901ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361901ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361901ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361901ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
5UTR-intronENST00000361901ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000393118ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000393118ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000393118ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000393118ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000393118ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000393118ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000495522ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000495522ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000495522ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000495522ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000495522ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000495522ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000424922ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000424922ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000424922ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000424922ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000424922ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000424922ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000543443ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000543443ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000543443ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000543443ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000543443ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000543443ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000466704ENST00000253861CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-3CDSENST00000466704ENST00000539845CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000466704ENST00000393161CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000466704ENST00000545148CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000466704ENST00000460346CALD1chr7

134464500

+EXOC4chr7

133749044

+
intron-intronENST00000466704ENST00000541309CALD1chr7

134464500

+EXOC4chr7

133749044

+

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FusionProtFeatures for CALD1_EXOC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALD1

Q05682

EXOC4

Q96A65

Actin- and myosin-binding protein implicated in theregulation of actomyosin interactions in smooth muscle andnonmuscle cells (could act as a bridge between myosin and actinfilaments). Stimulates actin binding of tropomyosin whichincreases the stabilization of actin filament structure. In muscletissues, inhibits the actomyosin ATPase by binding to F-actin.This inhibition is attenuated by calcium-calmodulin and ispotentiated by tropomyosin. Interacts with actin, myosin, twomolecules of tropomyosin and with calmodulin. Also play anessential role during cellular mitosis and receptor capping.Involved in Schwann cell migration during peripheral nerveregeneration (By similarity). {ECO:0000250,ECO:0000269|PubMed:8227296}. Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CALD1_EXOC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CALD1_EXOC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CALD1SHC1, TERF2, POT1, ARRB1, ISG15, TERF1, TINF2, ACTN1, HSP90AA1, CALM1, PAN2, PRKACA, LRCH3, EPB41L2, FH, PHAX, CSNK2A1, RPA3, RPA2, RPA1, TP53, CUL7, OBSL1, LUZP4, NTRK1, KIF11, MYH9, NEFM, TM9SF4, TACC3, GPSM2, LIMA1, FIGNL1, MYO19, OTUB1, CDH1, PDHA1, TESEXOC4MYC, DLG3, EXOC3, GRIN2B, DLG4, EXOC7, GTF2E2, DISC1, DTNBP1, CEP63, EXOC1, MYO5A, EXOC2, EXOC8, EXOC5, IQCB1, EGFR, ATG5, ATG12, BECN1, SNAP29, BSG, TPM1, SETDB1, EXOC6, NTRK1, MED4, SCLT1, OFD1, PCM1, CNTROB, FGFR1OP, CEP128, CEP44, CNTRL, ODF2, DYNLT1, TMEM17, SNW1, CDC5L, PTAR1, MTMR4, STX11, IKBIP, IL1R2, GGA1, APLNR, EXOC3L2, EXOC6B, TSSC1, RABEP2, VPS51, RABEP1, RALB, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CALD1_EXOC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CALD1_EXOC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCALD1C0003873Rheumatoid Arthritis1CTD_human
HgeneCALD1C3495559Juvenile arthritis1CTD_human