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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5287

FusionGeneSummary for CALD1_BRWD1

check button Fusion gene summary
Fusion gene informationFusion gene name: CALD1_BRWD1
Fusion gene ID: 5287
HgeneTgene
Gene symbol

CALD1

BRWD1

Gene ID

800

54014

Gene namecaldesmon 1bromodomain and WD repeat domain containing 1
SynonymsCDM|H-CAD|HCAD|L-CAD|LCAD|NAG22C21orf107|DCAF19|N143|WDR9|WRD9
Cytomap

7q33

21q22.2

Type of geneprotein-codingprotein-coding
Descriptioncaldesmontestis secretory sperm-binding protein Li 227nbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143
Modification date2018052220180523
UniProtAcc

Q05682

Q9NSI6

Ensembl transtripts involved in fusion geneENST00000417172, ENST00000361388, 
ENST00000422748, ENST00000361675, 
ENST00000361901, ENST00000393118, 
ENST00000495522, ENST00000424922, 
ENST00000543443, ENST00000466704, 
ENST00000333229, ENST00000342449, 
ENST00000380800, ENST00000341322, 
ENST00000470108, 
Fusion gene scores* DoF score14 X 16 X 9=20168 X 8 X 3=192
# samples 208
** MAII scorelog2(20/2016*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALD1 [Title/Abstract] AND BRWD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG980424CALD1chr7

134635143

-BRWD1chr21

40664869

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000417172ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000417172ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000417172ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000417172ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000417172ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
3UTR-intronENST00000466704ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
3UTR-intronENST00000466704ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
3UTR-intronENST00000466704ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
3UTR-intronENST00000466704ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
3UTR-intronENST00000466704ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+

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FusionProtFeatures for CALD1_BRWD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALD1

Q05682

BRWD1

Q9NSI6

Actin- and myosin-binding protein implicated in theregulation of actomyosin interactions in smooth muscle andnonmuscle cells (could act as a bridge between myosin and actinfilaments). Stimulates actin binding of tropomyosin whichincreases the stabilization of actin filament structure. In muscletissues, inhibits the actomyosin ATPase by binding to F-actin.This inhibition is attenuated by calcium-calmodulin and ispotentiated by tropomyosin. Interacts with actin, myosin, twomolecules of tropomyosin and with calmodulin. Also play anessential role during cellular mitosis and receptor capping.Involved in Schwann cell migration during peripheral nerveregeneration (By similarity). {ECO:0000250,ECO:0000269|PubMed:8227296}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CALD1_BRWD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CALD1_BRWD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CALD1_BRWD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CALD1_BRWD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCALD1C0003873Rheumatoid Arthritis1CTD_human
HgeneCALD1C3495559Juvenile arthritis1CTD_human
TgeneBRWD1C0028960Oligospermia1CTD_human