FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5281

FusionGeneSummary for CALCOCO2_ANKRD13A

check button Fusion gene summary
Fusion gene informationFusion gene name: CALCOCO2_ANKRD13A
Fusion gene ID: 5281
HgeneTgene
Gene symbol

CALCOCO2

ANKRD13A

Gene ID

10241

88455

Gene namecalcium binding and coiled-coil domain 2ankyrin repeat domain 13A
SynonymsNDP52ANKRD13|NY-REN-25
Cytomap

17q21.32

12q24.11

Type of geneprotein-codingprotein-coding
Descriptioncalcium-binding and coiled-coil domain-containing protein 2antigen nuclear dot 52 kDa proteinnuclear domain 10 protein 52nuclear domain 10 protein NDP52nuclear dot protein 52ankyrin repeat domain-containing protein 13ANY-REN-25 antigen
Modification date2018052220180519
UniProtAcc

Q13137

Q8IZ07

Ensembl transtripts involved in fusion geneENST00000258947, ENST00000509507, 
ENST00000448105, ENST00000416445, 
ENST00000508679, ENST00000510997, 
ENST00000550404, ENST00000261739, 
Fusion gene scores* DoF score4 X 3 X 3=364 X 4 X 2=32
# samples 46
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/32*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CALCOCO2 [Title/Abstract] AND ANKRD13A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCALCOCO2

GO:0034341

response to interferon-gamma

9230084


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-BP-5192-01ACALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000258947ENST00000550404CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
5CDS-intronENST00000258947ENST00000261739CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
5CDS-intronENST00000509507ENST00000550404CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
5CDS-intronENST00000509507ENST00000261739CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
5CDS-intronENST00000448105ENST00000550404CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
5CDS-intronENST00000448105ENST00000261739CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
intron-intronENST00000416445ENST00000550404CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
intron-intronENST00000416445ENST00000261739CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
5CDS-intronENST00000508679ENST00000550404CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
5CDS-intronENST00000508679ENST00000261739CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
intron-intronENST00000510997ENST00000550404CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+
intron-intronENST00000510997ENST00000261739CALCOCO2chr17

46926739

+ANKRD13Achr12

110461851

+

Top

FusionProtFeatures for CALCOCO2_ANKRD13A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALCOCO2

Q13137

ANKRD13A

Q8IZ07

Ubiquitin-binding protein that specifically recognizesand binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linkedubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFRat the cell membrane. {ECO:0000269|PubMed:22298428}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CALCOCO2_ANKRD13A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CALCOCO2_ANKRD13A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CALCOCO2TP53RK, LGALS8, FBF1, ZC2HC1C, CCDC185, LNX1, PIAS4, CCDC33, PSMA1, PTBP1, RABL6, CPNE7, ZNF101, LSM4, SHC1, GABARAPL2, VPS72, ZNF451, DBNDD2, ZNF638, FBXL18, ZNF205, FXR2, MCM10, POLI, PTBP2, AP5B1, KAT7, PCGF1, TCL1A, SMARCD1, TCEB3B, ABLIM1, CALCOCO2, ENKD1, ZNF426, C20orf195, SRI, FASTK, TRAF2, ZNF408, DAZAP2, RHPN1, APEX2, GABARAPL1, FAM107A, KANSL1, TAB3, TBK1, IKBKE, TBKBP1, MAP1LC3A, FMR1, MAVS, PRRC2A, KIAA1407, MTPAP, AZI2, TRAF4, MYO6, TAX1BP1, UBC, GEMIN4, IQCB1, RNF11, MAP1LC3C, DICER1, PARK2, SQSTM1, RPA2, ORC5, TRAF6, IKBKG, GIT2, RB1CC1, ADSL, ARNT2, MVP, NDN, PRKAB2, AES, CCNH, DCX, DDX6, DOCK2, HOXB9, LMO2, SMCP, MOS, MXI1, PFDN5, PHF1, RPL9, RPS27A, SDCBP, SNRPB, UBB, VARS, ARHGEF5, AKAP17A, NAA10, LMO4, STK16, TBRG4, FAM189A2, LITAF, EEF1E1, RIN1, AMMECR1, FARS2, MID2, DUSP12, BAHD1, PEG10, PSME4, FAM168A, PRPF31, ZNF337, NFU1, DCTN4, SLC15A3, ZNF581, HDAC7, CHCHD3, MAGOHB, FAM90A1, TBC1D22B, LIMS2, EXOSC5, CBX8, GATAD2B, KLHL42, FKBPL, TEKT3, METTL17, RBM15, DUSP26, LENG1, FAM161A, BEX2, RTN4IP1, ARHGEF39, LMF2, LONRF1, DDIT4L, GLYCTK, CWF19L2, ZNF564, PAPD4, PPP1R18, SPATA24, BCL6B, RTP5, CEP57L1, UBAC2, PEF1, RNF2, NRBF2, SULT1A2, BBOX1, CDK7, LDLRAD4, TTC23L, HLX, MAP1LC3B, GABARAP, U2AF2, ATG5, C1orf106, CHRDL1, SYNC, CEP55, BCAP29, HDAC11, RAB35, UBE2AANKRD13AUBC, TOLLIP, ELAVL1, LAPTM5, SMAD5, RNF11, EGFR, FBXO25, QDPR, FAM189B, TMEM51, CTDSP2, SLAMF1, FAM189A2, KCNIP2, WBP1, ERGIC3, ARRDC1, LDLRAD4, NTRK1, PSMD4, XPO1, VCP, CAV1, SMURF1, RALB, FAM153B, IZUMO1, CSNK1G3, ASB7, ZDHHC11, ARHGDIA, STOM, WBP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CALCOCO2_ANKRD13A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CALCOCO2_ANKRD13A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource