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Fusion gene ID: 5280 |
FusionGeneSummary for CALCOCO1_TK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CALCOCO1_TK1 | Fusion gene ID: 5280 | Hgene | Tgene | Gene symbol | CALCOCO1 | TK1 | Gene ID | 57658 | 7083 |
| Gene name | calcium binding and coiled-coil domain 1 | thymidine kinase 1 | |
| Synonyms | Cocoa|PP13275|calphoglin | TK2 | |
| Cytomap | 12q13.13 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium-binding and coiled-coil domain-containing protein 1coiled-coil coactivator proteincoiled-coil leucine zipper coactivator 1inorganic pyrophosphatase activatorsarcoma antigen NY-SAR-3 | thymidine kinase, cytosolicthymidine kinase 1 soluble isoform | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9P1Z2 | P04183 | |
| Ensembl transtripts involved in fusion gene | ENST00000430117, ENST00000262059, ENST00000548263, ENST00000550804, ENST00000547885, | ENST00000301634, ENST00000405273, ENST00000588734, ENST00000590862, ENST00000590430, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 4 X 3=60 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CALCOCO1 [Title/Abstract] AND TK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CALCOCO1 | GO:0010628 | positive regulation of gene expression | 16344550 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW376086 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000430117 | ENST00000301634 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000430117 | ENST00000405273 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000430117 | ENST00000588734 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000430117 | ENST00000590862 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000430117 | ENST00000590430 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000262059 | ENST00000301634 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000262059 | ENST00000405273 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000262059 | ENST00000588734 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000262059 | ENST00000590862 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000262059 | ENST00000590430 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000548263 | ENST00000301634 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000548263 | ENST00000405273 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000548263 | ENST00000588734 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000548263 | ENST00000590862 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000548263 | ENST00000590430 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000550804 | ENST00000301634 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000550804 | ENST00000405273 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000550804 | ENST00000588734 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000550804 | ENST00000590862 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000550804 | ENST00000590430 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000547885 | ENST00000301634 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000547885 | ENST00000405273 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000547885 | ENST00000588734 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000547885 | ENST00000590862 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
| intron-intron | ENST00000547885 | ENST00000590430 | CALCOCO1 | chr12 | 54105313 | + | TK1 | chr17 | 76176597 | + |
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FusionProtFeatures for CALCOCO1_TK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CALCOCO1 | TK1 |
| Functions as a coactivator for aryl hydrocarbon andnuclear receptors (NR). Recruited to promoters through its contactwith the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS)domain of transcription factors or coactivators, such as NCOA2.During ER-activation acts synergistically in combination withother NCOA2-binding proteins, such as EP300, CREBBP and CARM1.Involved in the transcriptional activation of target genes in theWnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction withCTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1involves differential utilization of two different activationregions (By similarity). In association with CCAR1 enhancesGATA1- and MED1-mediated transcriptional activation from thegamma-globin promoter during erythroid differentiation of K562erythroleukemia cells (PubMed:24245781).{ECO:0000250|UniProtKB:Q8CGU1, ECO:0000269|PubMed:24245781}. Seems to enhance inorganic pyrphosphatase thusactivating phosphogluomutase (PMG). Probably functions ascomponent of the calphoglin complex, which is involved in linkingcellular metabolism (phosphate and glucose metabolism) with othercore functions including protein synthesis and degradation,calcium signaling and cell growth. {ECO:0000269|Ref.1}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CALCOCO1_TK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CALCOCO1_TK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CALCOCO1_TK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CALCOCO1_TK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TK1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | TK1 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
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