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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5263

FusionGeneSummary for CADM3_DDX42

check button Fusion gene summary
Fusion gene informationFusion gene name: CADM3_DDX42
Fusion gene ID: 5263
HgeneTgene
Gene symbol

CADM3

DDX42

Gene ID

57863

11325

Gene namecell adhesion molecule 3DEAD-box helicase 42
SynonymsBIgR|IGSF4B|NECL1|Necl-1|TSLL1|synCAM3DDX42P|RHELP|RNAHP|SF3B8|SF3b125
Cytomap

1q23.2

17q23.3

Type of geneprotein-codingprotein-coding
Descriptioncell adhesion molecule 3TSLC1-like 1brain immunoglobulin receptordendritic cell nectin-like protein 1 short isoformimmunoglobulin superfamily member 4Bsynaptic cell adhesion molecule 3ATP-dependent RNA helicase DDX42DEAD (Asp-Glu-Ala-Asp) box helicase 42DEAD (Asp-Glu-Ala-Asp) box polypeptide 42SF3b DEAD box proteinsplicing factor 3B-associated 125 kDa proteinsplicing factor 3b, subunit 8
Modification date2018052220180519
UniProtAcc

Q8N126

Q86XP3

Ensembl transtripts involved in fusion geneENST00000368124, ENST00000368125, 
ENST00000497636, 
ENST00000578681, 
ENST00000583590, ENST00000359353, 
ENST00000389924, ENST00000457800, 
ENST00000582985, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 7 X 4=196
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CADM3 [Title/Abstract] AND DDX42 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDDX42

GO:0008104

protein localization

19377511


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB315810CADM3chr1

159172901

-DDX42chr17

61895212

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000368124ENST00000578681CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-3CDSENST00000368124ENST00000583590CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-3CDSENST00000368124ENST00000359353CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-3CDSENST00000368124ENST00000389924CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-3CDSENST00000368124ENST00000457800CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-intronENST00000368124ENST00000582985CADM3chr1

159172901

-DDX42chr17

61895212

-
3UTR-3CDSENST00000368125ENST00000578681CADM3chr1

159172901

-DDX42chr17

61895212

-
3UTR-3CDSENST00000368125ENST00000583590CADM3chr1

159172901

-DDX42chr17

61895212

-
3UTR-3CDSENST00000368125ENST00000359353CADM3chr1

159172901

-DDX42chr17

61895212

-
3UTR-3CDSENST00000368125ENST00000389924CADM3chr1

159172901

-DDX42chr17

61895212

-
3UTR-3CDSENST00000368125ENST00000457800CADM3chr1

159172901

-DDX42chr17

61895212

-
3UTR-intronENST00000368125ENST00000582985CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-3CDSENST00000497636ENST00000578681CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-3CDSENST00000497636ENST00000583590CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-3CDSENST00000497636ENST00000359353CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-3CDSENST00000497636ENST00000389924CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-3CDSENST00000497636ENST00000457800CADM3chr1

159172901

-DDX42chr17

61895212

-
intron-intronENST00000497636ENST00000582985CADM3chr1

159172901

-DDX42chr17

61895212

-

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FusionProtFeatures for CADM3_DDX42


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CADM3

Q8N126

DDX42

Q86XP3

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4,NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulatestructure or function of cell-cell junctions (By similarity).{ECO:0000250}. ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondarystructures. Unwinding is promoted in the presence of single-strandbinding proteins. Mediates also RNA duplex formation therebydisplacing the single-strand RNA binding protein. ATP and ADPmodulate its activity: ATP binding and hydrolysis by DDX42triggers RNA strand separation, whereas the ADP-bound form of theprotein triggers annealing of complementary RNA strands. Involvedin the survival of cells by interacting with TP53BP2 and therebycounteracting the apoptosis-stimulating activity of TP53BP2.Relocalizes TP53BP2 to the cytoplasm.{ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CADM3_DDX42


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CADM3_DDX42


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CADM3_DDX42


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CADM3_DDX42


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource