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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5261

FusionGeneSummary for CADM2_UBE2E2

check button Fusion gene summary
Fusion gene informationFusion gene name: CADM2_UBE2E2
Fusion gene ID: 5261
HgeneTgene
Gene symbol

CADM2

UBE2E2

Gene ID

253559

7325

Gene namecell adhesion molecule 2ubiquitin conjugating enzyme E2 E2
SynonymsIGSF4D|NECL3|Necl-3|SynCAM 2|synCAM2UBCH8
Cytomap

3p12.1

3p24.3

Type of geneprotein-codingprotein-coding
Descriptioncell adhesion molecule 2immunoglobulin superfamily member 4Dnectin-like 3nectin-like protein 3synaptic cell adhesion molecule 2ubiquitin-conjugating enzyme E2 E2E2 ubiquitin-conjugating enzyme E2ubiquitin carrier protein E2ubiquitin conjugating enzyme E2E 2ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)ubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5
Modification date2018051920180523
UniProtAcc

Q8N3J6

Q96LR5

Ensembl transtripts involved in fusion geneENST00000383699, ENST00000407528, 
ENST00000405615, ENST00000485126, 
ENST00000425792, ENST00000396703, 
Fusion gene scores* DoF score6 X 5 X 3=906 X 5 X 4=120
# samples 76
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CADM2 [Title/Abstract] AND UBE2E2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE2E2

GO:0032020

ISG15-protein conjugation

16428300

TgeneUBE2E2

GO:0070534

protein K63-linked ubiquitination

20061386

TgeneUBE2E2

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneUBE2E2

GO:0070979

protein K11-linked ubiquitination

20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-FC-A4JI-01ACADM2chr3

85008819

+UBE2E2chr3

23574045

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000383699ENST00000425792CADM2chr3

85008819

+UBE2E2chr3

23574045

+
Frame-shiftENST00000383699ENST00000396703CADM2chr3

85008819

+UBE2E2chr3

23574045

+
Frame-shiftENST00000407528ENST00000425792CADM2chr3

85008819

+UBE2E2chr3

23574045

+
Frame-shiftENST00000407528ENST00000396703CADM2chr3

85008819

+UBE2E2chr3

23574045

+
intron-3CDSENST00000405615ENST00000425792CADM2chr3

85008819

+UBE2E2chr3

23574045

+
intron-3CDSENST00000405615ENST00000396703CADM2chr3

85008819

+UBE2E2chr3

23574045

+
3UTR-3CDSENST00000485126ENST00000425792CADM2chr3

85008819

+UBE2E2chr3

23574045

+
3UTR-3CDSENST00000485126ENST00000396703CADM2chr3

85008819

+UBE2E2chr3

23574045

+

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FusionProtFeatures for CADM2_UBE2E2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CADM2

Q8N3J6

UBE2E2

Q96LR5

Adhesion molecule that engages in homo- and heterophilicinteractions with the other nectin-like family members, leading tocell aggregation. Important for synapse organization, providingregulated trans-synaptic adhesion. Preferentially binds tooligodendrocytes. {ECO:0000269|PubMed:17967169}. Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.Catalyzes the ISGylation of influenza A virus NS1 protein.{ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869,ECO:0000269|PubMed:9371400}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CADM2_UBE2E2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CADM2_UBE2E2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CADM2NUFIP1UBE2E2RNF14, RNF8, STUB1, PCGF2, RNF5, ZNRF1, RNF114, RNF11, ARIH2, DTX3L, DZIP3, TRIM23, TRIM39, RNF185, RNF2, RNF25, XIAP, RNF125, RNF4, UBOX5, RING1, MARCH3, DTX3, RLIM, CHFR, MID1, MKRN3, RNF10, RNF111, RNF166, TRIM2, RUNX1T1, PRAM1, SIAH1, HDAC2, PARK2, BRCA1, ELAVL1, MID2, TRIM32, TRIM50, TRIM37, TRIM38, TRIM45, TRIM27, TRIM31, SPEN, UBA1, IPO11, RNF103, NFE2L2, CUL3, TRIM28, BARD1, MDM2, APP, PTBP2, UNG, SRPK2, SRPK1, UBE2E2, ARIH1, MUL1, DAZAP2, ARRDC3, FAM9B, DDA1, PDLIM2, RC3H2, OTUB1, DTL, RBX1, DET1, USP15, NEDD4L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CADM2_UBE2E2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CADM2_UBE2E2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUBE2E2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human