|
Fusion gene ID: 5261 |
FusionGeneSummary for CADM2_UBE2E2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: CADM2_UBE2E2 | Fusion gene ID: 5261 | Hgene | Tgene | Gene symbol | CADM2 | UBE2E2 | Gene ID | 253559 | 7325 |
Gene name | cell adhesion molecule 2 | ubiquitin conjugating enzyme E2 E2 | |
Synonyms | IGSF4D|NECL3|Necl-3|SynCAM 2|synCAM2 | UBCH8 | |
Cytomap | 3p12.1 | 3p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cell adhesion molecule 2immunoglobulin superfamily member 4Dnectin-like 3nectin-like protein 3synaptic cell adhesion molecule 2 | ubiquitin-conjugating enzyme E2 E2E2 ubiquitin-conjugating enzyme E2ubiquitin carrier protein E2ubiquitin conjugating enzyme E2E 2ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)ubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8N3J6 | Q96LR5 | |
Ensembl transtripts involved in fusion gene | ENST00000383699, ENST00000407528, ENST00000405615, ENST00000485126, | ENST00000425792, ENST00000396703, | |
Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 6 X 5 X 4=120 |
# samples | 7 | 6 | |
** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CADM2 [Title/Abstract] AND UBE2E2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | UBE2E2 | GO:0032020 | ISG15-protein conjugation | 16428300 |
Tgene | UBE2E2 | GO:0070534 | protein K63-linked ubiquitination | 20061386 |
Tgene | UBE2E2 | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
Tgene | UBE2E2 | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-FC-A4JI-01A | CADM2 | chr3 | 85008819 | + | UBE2E2 | chr3 | 23574045 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000383699 | ENST00000425792 | CADM2 | chr3 | 85008819 | + | UBE2E2 | chr3 | 23574045 | + |
Frame-shift | ENST00000383699 | ENST00000396703 | CADM2 | chr3 | 85008819 | + | UBE2E2 | chr3 | 23574045 | + |
Frame-shift | ENST00000407528 | ENST00000425792 | CADM2 | chr3 | 85008819 | + | UBE2E2 | chr3 | 23574045 | + |
Frame-shift | ENST00000407528 | ENST00000396703 | CADM2 | chr3 | 85008819 | + | UBE2E2 | chr3 | 23574045 | + |
intron-3CDS | ENST00000405615 | ENST00000425792 | CADM2 | chr3 | 85008819 | + | UBE2E2 | chr3 | 23574045 | + |
intron-3CDS | ENST00000405615 | ENST00000396703 | CADM2 | chr3 | 85008819 | + | UBE2E2 | chr3 | 23574045 | + |
3UTR-3CDS | ENST00000485126 | ENST00000425792 | CADM2 | chr3 | 85008819 | + | UBE2E2 | chr3 | 23574045 | + |
3UTR-3CDS | ENST00000485126 | ENST00000396703 | CADM2 | chr3 | 85008819 | + | UBE2E2 | chr3 | 23574045 | + |
Top |
FusionProtFeatures for CADM2_UBE2E2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CADM2 | UBE2E2 |
Adhesion molecule that engages in homo- and heterophilicinteractions with the other nectin-like family members, leading tocell aggregation. Important for synapse organization, providingregulated trans-synaptic adhesion. Preferentially binds tooligodendrocytes. {ECO:0000269|PubMed:17967169}. | Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.Catalyzes the ISGylation of influenza A virus NS1 protein.{ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869,ECO:0000269|PubMed:9371400}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CADM2_UBE2E2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CADM2_UBE2E2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CADM2 | NUFIP1 | UBE2E2 | RNF14, RNF8, STUB1, PCGF2, RNF5, ZNRF1, RNF114, RNF11, ARIH2, DTX3L, DZIP3, TRIM23, TRIM39, RNF185, RNF2, RNF25, XIAP, RNF125, RNF4, UBOX5, RING1, MARCH3, DTX3, RLIM, CHFR, MID1, MKRN3, RNF10, RNF111, RNF166, TRIM2, RUNX1T1, PRAM1, SIAH1, HDAC2, PARK2, BRCA1, ELAVL1, MID2, TRIM32, TRIM50, TRIM37, TRIM38, TRIM45, TRIM27, TRIM31, SPEN, UBA1, IPO11, RNF103, NFE2L2, CUL3, TRIM28, BARD1, MDM2, APP, PTBP2, UNG, SRPK2, SRPK1, UBE2E2, ARIH1, MUL1, DAZAP2, ARRDC3, FAM9B, DDA1, PDLIM2, RC3H2, OTUB1, DTL, RBX1, DET1, USP15, NEDD4L |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CADM2_UBE2E2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CADM2_UBE2E2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | UBE2E2 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |