FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5246

FusionGeneSummary for CACUL1_CACUL1

check button Fusion gene summary
Fusion gene informationFusion gene name: CACUL1_CACUL1
Fusion gene ID: 5246
HgeneTgene
Gene symbol

CACUL1

CACUL1

Gene ID

143384

143384

Gene nameCDK2 associated cullin domain 1CDK2 associated cullin domain 1
SynonymsC10orf46|CAC1C10orf46|CAC1
Cytomap

10q26.11

10q26.11

Type of geneprotein-codingprotein-coding
DescriptionCDK2-associated and cullin domain-containing protein 1Cdk-Associated Cullin1cullinCDK2-associated and cullin domain-containing protein 1Cdk-Associated Cullin1cullin
Modification date2018052220180522
UniProtAcc

Q86Y37

Q86Y37

Ensembl transtripts involved in fusion geneENST00000544392, ENST00000369151, 
ENST00000340214, 		ENST00000544392, 
ENST00000369151, ENST00000340214, 
Fusion gene scores* DoF score5 X 5 X 3=753 X 4 X 2=24
# samples 54
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CACUL1 [Title/Abstract] AND CACUL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI829926CACUL1chr10

120514198

+CACUL1chr10

120443446

+
ChiTaRS3.1BF530533CACUL1chr10

120442646

+CACUL1chr10

120442576

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000544392ENST00000544392CACUL1chr10

120514198

+CACUL1chr10

120443446

+
intron-3UTRENST00000544392ENST00000369151CACUL1chr10

120514198

+CACUL1chr10

120443446

+
intron-intronENST00000544392ENST00000340214CACUL1chr10

120514198

+CACUL1chr10

120443446

+
intron-intronENST00000369151ENST00000544392CACUL1chr10

120514198

+CACUL1chr10

120443446

+
intron-3UTRENST00000369151ENST00000369151CACUL1chr10

120514198

+CACUL1chr10

120443446

+
intron-intronENST00000369151ENST00000340214CACUL1chr10

120514198

+CACUL1chr10

120443446

+
intron-intronENST00000340214ENST00000544392CACUL1chr10

120514198

+CACUL1chr10

120443446

+
intron-3UTRENST00000340214ENST00000369151CACUL1chr10

120514198

+CACUL1chr10

120443446

+
intron-intronENST00000340214ENST00000340214CACUL1chr10

120514198

+CACUL1chr10

120443446

+
intron-intronENST00000544392ENST00000544392CACUL1chr10

120442646

+CACUL1chr10

120442576

-
intron-3UTRENST00000544392ENST00000369151CACUL1chr10

120442646

+CACUL1chr10

120442576

-
intron-intronENST00000544392ENST00000340214CACUL1chr10

120442646

+CACUL1chr10

120442576

-
intron-intronENST00000369151ENST00000544392CACUL1chr10

120442646

+CACUL1chr10

120442576

-
intron-3UTRENST00000369151ENST00000369151CACUL1chr10

120442646

+CACUL1chr10

120442576

-
intron-intronENST00000369151ENST00000340214CACUL1chr10

120442646

+CACUL1chr10

120442576

-
intron-intronENST00000340214ENST00000544392CACUL1chr10

120442646

+CACUL1chr10

120442576

-
intron-3UTRENST00000340214ENST00000369151CACUL1chr10

120442646

+CACUL1chr10

120442576

-
intron-intronENST00000340214ENST00000340214CACUL1chr10

120442646

+CACUL1chr10

120442576

-

Top

FusionProtFeatures for CACUL1_CACUL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CACUL1

Q86Y37

CACUL1

Q86Y37

Cell cycle associated protein capable of promoting cellproliferation through the activation of CDK2 at the G1/S phasetransition. {ECO:0000269|PubMed:19829063}. Cell cycle associated protein capable of promoting cellproliferation through the activation of CDK2 at the G1/S phasetransition. {ECO:0000269|PubMed:19829063}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CACUL1_CACUL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CACUL1_CACUL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CACUL1_CACUL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CACUL1_CACUL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource