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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5245

FusionGeneSummary for CACTIN_CACTIN

check button Fusion gene summary
Fusion gene informationFusion gene name: CACTIN_CACTIN
Fusion gene ID: 5245
HgeneTgene
Gene symbol

CACTIN

CACTIN

Gene ID

58509

58509

Gene namecactin, spliceosome C complex subunitcactin, spliceosome C complex subunit
SynonymsC19orf29|NY-REN-24|fSAPcC19orf29|NY-REN-24|fSAPc
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
DescriptioncactinNY REN 24 antigenfunctional spliceosome-associated protein crenal carcinoma antigen NY-REN-24cactinNY REN 24 antigenfunctional spliceosome-associated protein crenal carcinoma antigen NY-REN-24
Modification date2018051920180519
UniProtAcc

Q8WUQ7

Q8WUQ7

Ensembl transtripts involved in fusion geneENST00000429344, ENST00000248420, 
ENST00000221899, 
ENST00000429344, 
ENST00000248420, ENST00000221899, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: CACTIN [Title/Abstract] AND CACTIN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCACTIN

GO:0032088

negative regulation of NF-kappaB transcription factor activity

20829348

HgeneCACTIN

GO:0032717

negative regulation of interleukin-8 production

20829348

HgeneCACTIN

GO:0032720

negative regulation of tumor necrosis factor production

20829348

HgeneCACTIN

GO:0034122

negative regulation of toll-like receptor signaling pathway

20829348

HgeneCACTIN

GO:0071222

cellular response to lipopolysaccharide

20829348

HgeneCACTIN

GO:0071347

cellular response to interleukin-1

20829348

HgeneCACTIN

GO:0071356

cellular response to tumor necrosis factor

20829348

TgeneCACTIN

GO:0032088

negative regulation of NF-kappaB transcription factor activity

20829348

TgeneCACTIN

GO:0032717

negative regulation of interleukin-8 production

20829348

TgeneCACTIN

GO:0032720

negative regulation of tumor necrosis factor production

20829348

TgeneCACTIN

GO:0034122

negative regulation of toll-like receptor signaling pathway

20829348

TgeneCACTIN

GO:0071222

cellular response to lipopolysaccharide

20829348

TgeneCACTIN

GO:0071347

cellular response to interleukin-1

20829348

TgeneCACTIN

GO:0071356

cellular response to tumor necrosis factor

20829348


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI000523CACTINchr19

3622171

+CACTINchr19

3622883

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000429344ENST00000429344CACTINchr19

3622171

+CACTINchr19

3622883

-
intron-intronENST00000429344ENST00000248420CACTINchr19

3622171

+CACTINchr19

3622883

-
intron-intronENST00000429344ENST00000221899CACTINchr19

3622171

+CACTINchr19

3622883

-
intron-intronENST00000248420ENST00000429344CACTINchr19

3622171

+CACTINchr19

3622883

-
intron-intronENST00000248420ENST00000248420CACTINchr19

3622171

+CACTINchr19

3622883

-
intron-intronENST00000248420ENST00000221899CACTINchr19

3622171

+CACTINchr19

3622883

-
intron-intronENST00000221899ENST00000429344CACTINchr19

3622171

+CACTINchr19

3622883

-
intron-intronENST00000221899ENST00000248420CACTINchr19

3622171

+CACTINchr19

3622883

-
intron-intronENST00000221899ENST00000221899CACTINchr19

3622171

+CACTINchr19

3622883

-

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FusionProtFeatures for CACTIN_CACTIN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CACTIN

Q8WUQ7

CACTIN

Q8WUQ7

Involved in the regulation of innate immune response.Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to theregulation of transcriptional activation of NF-kappa-B targetgenes in response to endogenous proinflammatory stimuli. May playa role during early embryonic development. Probably involved inpre-mRNA splicing. {ECO:0000269|PubMed:20829348}. Involved in the regulation of innate immune response.Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to theregulation of transcriptional activation of NF-kappa-B targetgenes in response to endogenous proinflammatory stimuli. May playa role during early embryonic development. Probably involved inpre-mRNA splicing. {ECO:0000269|PubMed:20829348}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CACTIN_CACTIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CACTIN_CACTIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CACTIN_CACTIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CACTIN_CACTIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource