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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5144

FusionGeneSummary for CAB39_CAB39

check button Fusion gene summary
Fusion gene informationFusion gene name: CAB39_CAB39
Fusion gene ID: 5144
HgeneTgene
Gene symbol

CAB39

CAB39

Gene ID

51719

51719

Gene namecalcium binding protein 39calcium binding protein 39
SynonymsCGI-66|MO25CGI-66|MO25
Cytomap

2q37.1

2q37.1

Type of geneprotein-codingprotein-coding
Descriptioncalcium-binding protein 39MO25alphacalcium-binding protein 39MO25alpha
Modification date2018052320180523
UniProtAcc

Q9Y376

Q9Y376

Ensembl transtripts involved in fusion geneENST00000258418, ENST00000410084, 
ENST00000409788, ENST00000484398, 
ENST00000258418, ENST00000410084, 
ENST00000409788, ENST00000484398, 
Fusion gene scores* DoF score4 X 3 X 4=485 X 5 X 3=75
# samples 67
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAB39 [Title/Abstract] AND CAB39 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAB39

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24393035

HgeneCAB39

GO:0018105

peptidyl-serine phosphorylation

24393035

HgeneCAB39

GO:0023014

signal transduction by protein phosphorylation

24393035

HgeneCAB39

GO:0035556

intracellular signal transduction

24393035

HgeneCAB39

GO:0071902

positive regulation of protein serine/threonine kinase activity

19892943|24393035

TgeneCAB39

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24393035

TgeneCAB39

GO:0018105

peptidyl-serine phosphorylation

24393035

TgeneCAB39

GO:0023014

signal transduction by protein phosphorylation

24393035

TgeneCAB39

GO:0035556

intracellular signal transduction

24393035

TgeneCAB39

GO:0071902

positive regulation of protein serine/threonine kinase activity

19892943|24393035


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF134480CAB39chr2

231683960

+CAB39chr2

231683565

-
ChiTaRS3.1F00930CAB39chr2

231683960

+CAB39chr2

231683565

-
ChiTaRS3.1AF151824CAB39chr2

231683960

+CAB39chr2

231683565

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000258418ENST00000258418CAB39chr2

231683960

+CAB39chr2

231683565

-
3UTR-intronENST00000258418ENST00000410084CAB39chr2

231683960

+CAB39chr2

231683565

-
3UTR-intronENST00000258418ENST00000409788CAB39chr2

231683960

+CAB39chr2

231683565

-
3UTR-intronENST00000258418ENST00000484398CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-3UTRENST00000410084ENST00000258418CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-intronENST00000410084ENST00000410084CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-intronENST00000410084ENST00000409788CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-intronENST00000410084ENST00000484398CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-3UTRENST00000409788ENST00000258418CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-intronENST00000409788ENST00000410084CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-intronENST00000409788ENST00000409788CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-intronENST00000409788ENST00000484398CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-3UTRENST00000484398ENST00000258418CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-intronENST00000484398ENST00000410084CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-intronENST00000484398ENST00000409788CAB39chr2

231683960

+CAB39chr2

231683565

-
intron-intronENST00000484398ENST00000484398CAB39chr2

231683960

+CAB39chr2

231683565

-

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FusionProtFeatures for CAB39_CAB39


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAB39

Q9Y376

CAB39

Q9Y376

Component of a complex that binds and activatesSTK11/LKB1. In the complex, required to stabilize the interactionbetween CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) andSTK11/LKB1. {ECO:0000269|PubMed:19892943}. Component of a complex that binds and activatesSTK11/LKB1. In the complex, required to stabilize the interactionbetween CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) andSTK11/LKB1. {ECO:0000269|PubMed:19892943}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CAB39_CAB39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAB39_CAB39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAB39_CAB39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CAB39_CAB39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource