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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5135

FusionGeneSummary for CA8_CORO2B

check button Fusion gene summary
Fusion gene informationFusion gene name: CA8_CORO2B
Fusion gene ID: 5135
HgeneTgene
Gene symbol

CA8

CORO2B

Gene ID

767

10391

Gene namecarbonic anhydrase 8coronin 2B
SynonymsCA-RP|CA-VIII|CALS|CAMRQ3|CARPCLIPINC
Cytomap

8q12.1

15q23

Type of geneprotein-codingprotein-coding
Descriptioncarbonic anhydrase-related proteinCA-related proteincarbonate dehydratasecarbonic anhydrase VIIIcarbonic anhydrase-like sequencecoronin-2Bclipin Ccoronin, actin binding protein, 2Bcoronin-like protein C
Modification date2018052220180519
UniProtAcc

P35219

Q9UQ03

Ensembl transtripts involved in fusion geneENST00000317995, ENST00000528666, 
ENST00000261861, ENST00000566799, 
ENST00000540068, ENST00000543950, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: CA8 [Title/Abstract] AND CORO2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA070111CA8chr8

61193904

-CORO2Bchr15

68987546

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000317995ENST00000261861CA8chr8

61193904

-CORO2Bchr15

68987546

+
intron-3CDSENST00000317995ENST00000566799CA8chr8

61193904

-CORO2Bchr15

68987546

+
intron-3CDSENST00000317995ENST00000540068CA8chr8

61193904

-CORO2Bchr15

68987546

+
intron-3CDSENST00000317995ENST00000543950CA8chr8

61193904

-CORO2Bchr15

68987546

+
intron-3CDSENST00000528666ENST00000261861CA8chr8

61193904

-CORO2Bchr15

68987546

+
intron-3CDSENST00000528666ENST00000566799CA8chr8

61193904

-CORO2Bchr15

68987546

+
intron-3CDSENST00000528666ENST00000540068CA8chr8

61193904

-CORO2Bchr15

68987546

+
intron-3CDSENST00000528666ENST00000543950CA8chr8

61193904

-CORO2Bchr15

68987546

+

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FusionProtFeatures for CA8_CORO2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CA8

P35219

CORO2B

Q9UQ03

Does not have a carbonic anhydrase catalytic activity. May play a role in the reorganization of neuronal actinstructure.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CA8_CORO2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CA8_CORO2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CA8_CORO2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCA8P35219DB00909ZonisamideCarbonic anhydrase-related proteinsmall moleculeapproved|investigational

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RelatedDiseases for CA8_CORO2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCA8C2750509Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 31CTD_human;UNIPROT
HgeneCA8C3714756Intellectual Disability1CTD_human;HPO