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Fusion gene ID: 5133 |
FusionGeneSummary for CA3_MYBL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CA3_MYBL1 | Fusion gene ID: 5133 | Hgene | Tgene | Gene symbol | CA3 | MYBL1 | Gene ID | 761 | 4603 |
| Gene name | carbonic anhydrase 3 | MYB proto-oncogene like 1 | |
| Synonyms | CAIII|Car3 | A-MYB|AMYB | |
| Cytomap | 8q21.2 | 8q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carbonic anhydrase 3CA-IIIHEL-S-167mPcarbonate dehydratase IIIcarbonic anhydrase III, muscle specificepididymis secretory sperm binding protein Li 167mP | myb-related protein Amyb-like protein 1v-myb avian myeloblastosis viral oncogene homolog-like 1 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P07451 | P10243 | |
| Ensembl transtripts involved in fusion gene | ENST00000285381, | ENST00000522677, ENST00000517885, ENST00000524176, ENST00000522419, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CA3 [Title/Abstract] AND MYBL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MYBL1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7987850 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AR-A256-01A | CA3 | chr8 | 86356355 | + | MYBL1 | chr8 | 67479227 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000285381 | ENST00000522677 | CA3 | chr8 | 86356355 | + | MYBL1 | chr8 | 67479227 | - |
| In-frame | ENST00000285381 | ENST00000517885 | CA3 | chr8 | 86356355 | + | MYBL1 | chr8 | 67479227 | - |
| In-frame | ENST00000285381 | ENST00000524176 | CA3 | chr8 | 86356355 | + | MYBL1 | chr8 | 67479227 | - |
| 5CDS-intron | ENST00000285381 | ENST00000522419 | CA3 | chr8 | 86356355 | + | MYBL1 | chr8 | 67479227 | - |
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FusionProtFeatures for CA3_MYBL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CA3 | MYBL1 |
| Reversible hydration of carbon dioxide. | Transcription factor that specifically recognizes thesequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts asa master regulator of male meiosis by promoting expression ofpiRNAs: activates expression of both piRNA precursor RNAs andexpression of protein-coding genes involved in piRNA metabolism(By similarity). The piRNA metabolic process mediates therepression of transposable elements during meiosis by formingcomplexes composed of piRNAs and Piwi proteins and governs themethylation and subsequent repression of transposons, which isessential for the germline integrity (By similarity).{ECO:0000250|UniProtKB:P51960, ECO:0000269|PubMed:7987850,ECO:0000269|PubMed:8058310}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CA3 | chr8:86356355 | chr8:67479227 | ENST00000285381 | + | 4 | 7 | 64_67 | 148 | 261 | Region | Note=Involved in proton transfer |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CA3 | chr8:86356355 | chr8:67479227 | ENST00000285381 | + | 4 | 7 | 3_259 | 148 | 261 | Domain | Alpha-carbonic anhydrase |
| Hgene | >CA3 | chr8:86356355 | chr8:67479227 | ENST00000285381 | + | 4 | 7 | 198_199 | 148 | 261 | Region | Substrate binding |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000522677 | - | 11 | 16 | 110_133 | 576 | 753 | DNA binding | H-T-H motif |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000522677 | - | 11 | 16 | 161_184 | 576 | 753 | DNA binding | H-T-H motif |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000522677 | - | 11 | 16 | 58_81 | 576 | 753 | DNA binding | H-T-H motif |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000524176 | - | 11 | 15 | 110_133 | 576 | 693 | DNA binding | H-T-H motif |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000524176 | - | 11 | 15 | 161_184 | 576 | 693 | DNA binding | H-T-H motif |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000524176 | - | 11 | 15 | 58_81 | 576 | 693 | DNA binding | H-T-H motif |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000522677 | - | 11 | 16 | 138_188 | 576 | 753 | Domain | HTH myb-type 3 |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000522677 | - | 11 | 16 | 30_81 | 576 | 753 | Domain | HTH myb-type 1 |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000522677 | - | 11 | 16 | 82_137 | 576 | 753 | Domain | HTH myb-type 2 |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000524176 | - | 11 | 15 | 138_188 | 576 | 693 | Domain | HTH myb-type 3 |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000524176 | - | 11 | 15 | 30_81 | 576 | 693 | Domain | HTH myb-type 1 |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000524176 | - | 11 | 15 | 82_137 | 576 | 693 | Domain | HTH myb-type 2 |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000522677 | - | 11 | 16 | 230_295 | 576 | 753 | Region | Transcriptional activation domain |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000522677 | - | 11 | 16 | 298_553 | 576 | 753 | Region | Negative regulatory domain |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000524176 | - | 11 | 15 | 230_295 | 576 | 693 | Region | Transcriptional activation domain |
| Tgene | MYBL1 | chr8:86356355 | chr8:67479227 | ENST00000524176 | - | 11 | 15 | 298_553 | 576 | 693 | Region | Negative regulatory domain |
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FusionGeneSequence for CA3_MYBL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CA3_ENST00000285381_chr8_86356355_+_MYBL1_ENST00000522677_chr8_67479227_-_325aa MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRL RQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKSQPLAFLEEDIREVLKEETGTDLFLKEEDEPA YKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISDMQSENRFTTSLLMIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPN >In-frame_CA3_ENST00000285381_chr8_86356355_+_MYBL1_ENST00000517885_chr8_67479227_-_325aa MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRL RQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKSQPLAFLEEDIREVLKEETGTDLFLKEEDEPA YKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISDMQSENRFTTSLLMIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPN >In-frame_CA3_ENST00000285381_chr8_86356355_+_MYBL1_ENST00000524176_chr8_67479227_-_265aa MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRL RQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKSQPLAFLEEDIREVLKEETGTDLFLKEEDEPA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CA3_ENST00000285381_chr8_86356355_+_MYBL1_ENST00000522677_chr8_67479227_-_975nt ATGGCCAAGGAGTGGGGCTACGCCAGTCACAACGGTCCTGACCACTGGCATGAACTTTTCCCAAATGCCAAGGGGGAAAACCAGTCGCCC GTTGAGCTGCATACTAAAGACATCAGGCATGACCCTTCTCTGCAGCCATGGTCTGTGTCTTATGATGGTGGCTCTGCCAAGACCATCCTG AATAATGGGAAGACCTGCCGAGTTGTATTTGATGATACTTATGATAGGTCAATGCTGAGAGGGGGTCCTCTCCCTGGACCCTACCGACTT CGCCAGTTTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCGTGGATGGAGTCAAGTATGCAGCGGAGCTTCATTTG GTTCACTGGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATGGGATCGCTGTGATTGGCATTTTTCTGAAGTCCCAG CCACTTGCTTTCTTGGAAGAAGATATTCGGGAAGTTTTAAAAGAAGAAACTGGAACAGACCTATTCCTCAAAGAGGAAGATGAACCTGCT TACAAAAGCTGCAAACAAGAGAATACCGCTTCTGGGAAGAAAGTCAGAAAATCACTAGTCTTAGATAATTGGGAAAAAGAAGAATCAGGC ACTCAACTGTTGACTGAAGACATTTCAGACATGCAGTCAGAAAATAGATTTACTACATCCTTATTAATGATACCATTATTGGAAATACAT GACAATAGGTGCAACTTGATTCCTGAAAAACAAGATATAAATTCAACCAACAAAACATATACACTTACTAAAAAGAAACCAAACCCTAAC ACTTCCAAAGTTGTCAAATTGGAAAAGAATCTTCAGTCAAATTGTGAATGGGAAACAGTGGTTTATGGGAAGACAGAAGACCAACTTATT >In-frame_CA3_ENST00000285381_chr8_86356355_+_MYBL1_ENST00000517885_chr8_67479227_-_975nt ATGGCCAAGGAGTGGGGCTACGCCAGTCACAACGGTCCTGACCACTGGCATGAACTTTTCCCAAATGCCAAGGGGGAAAACCAGTCGCCC GTTGAGCTGCATACTAAAGACATCAGGCATGACCCTTCTCTGCAGCCATGGTCTGTGTCTTATGATGGTGGCTCTGCCAAGACCATCCTG AATAATGGGAAGACCTGCCGAGTTGTATTTGATGATACTTATGATAGGTCAATGCTGAGAGGGGGTCCTCTCCCTGGACCCTACCGACTT CGCCAGTTTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCGTGGATGGAGTCAAGTATGCAGCGGAGCTTCATTTG GTTCACTGGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATGGGATCGCTGTGATTGGCATTTTTCTGAAGTCCCAG CCACTTGCTTTCTTGGAAGAAGATATTCGGGAAGTTTTAAAAGAAGAAACTGGAACAGACCTATTCCTCAAAGAGGAAGATGAACCTGCT TACAAAAGCTGCAAACAAGAGAATACCGCTTCTGGGAAGAAAGTCAGAAAATCACTAGTCTTAGATAATTGGGAAAAAGAAGAATCAGGC ACTCAACTGTTGACTGAAGACATTTCAGACATGCAGTCAGAAAATAGATTTACTACATCCTTATTAATGATACCATTATTGGAAATACAT GACAATAGGTGCAACTTGATTCCTGAAAAACAAGATATAAATTCAACCAACAAAACATATACACTTACTAAAAAGAAACCAAACCCTAAC ACTTCCAAAGTTGTCAAATTGGAAAAGAATCTTCAGTCAAATTGTGAATGGGAAACAGTGGTTTATGGGAAGACAGAAGACCAACTTATT >In-frame_CA3_ENST00000285381_chr8_86356355_+_MYBL1_ENST00000524176_chr8_67479227_-_795nt ATGGCCAAGGAGTGGGGCTACGCCAGTCACAACGGTCCTGACCACTGGCATGAACTTTTCCCAAATGCCAAGGGGGAAAACCAGTCGCCC GTTGAGCTGCATACTAAAGACATCAGGCATGACCCTTCTCTGCAGCCATGGTCTGTGTCTTATGATGGTGGCTCTGCCAAGACCATCCTG AATAATGGGAAGACCTGCCGAGTTGTATTTGATGATACTTATGATAGGTCAATGCTGAGAGGGGGTCCTCTCCCTGGACCCTACCGACTT CGCCAGTTTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCGTGGATGGAGTCAAGTATGCAGCGGAGCTTCATTTG GTTCACTGGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATGGGATCGCTGTGATTGGCATTTTTCTGAAGTCCCAG CCACTTGCTTTCTTGGAAGAAGATATTCGGGAAGTTTTAAAAGAAGAAACTGGAACAGACCTATTCCTCAAAGAGGAAGATGAACCTGCT TACAAAAGCTGCAAACAAGAGAATACCGCTTCTGGGAAGAAAGTCAGAAAATCACTAGTCTTAGATAATTGGGAAAAAGAAGAATCAGGC ACTCAACTGTTGACTGAAGACATTTCAGACATGCAGTCAAATTGTGAATGGGAAACAGTGGTTTATGGGAAGACAGAAGACCAACTTATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CA3_ENST00000285381_chr8_86356355_+_MYBL1_ENST00000522677_chr8_67479227_-_3580nt ACATAAAAGCGCGGGCTCGCGGCGACTCTGCACCACGCAGGGGAAGAGAAAGCAGGAGCCGTCCAGCACGGAGGAAGGCGACCATGGCCA AGGAGTGGGGCTACGCCAGTCACAACGGTCCTGACCACTGGCATGAACTTTTCCCAAATGCCAAGGGGGAAAACCAGTCGCCCGTTGAGC TGCATACTAAAGACATCAGGCATGACCCTTCTCTGCAGCCATGGTCTGTGTCTTATGATGGTGGCTCTGCCAAGACCATCCTGAATAATG GGAAGACCTGCCGAGTTGTATTTGATGATACTTATGATAGGTCAATGCTGAGAGGGGGTCCTCTCCCTGGACCCTACCGACTTCGCCAGT TTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCGTGGATGGAGTCAAGTATGCAGCGGAGCTTCATTTGGTTCACT GGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATGGGATCGCTGTGATTGGCATTTTTCTGAAGTCCCAGCCACTTG CTTTCTTGGAAGAAGATATTCGGGAAGTTTTAAAAGAAGAAACTGGAACAGACCTATTCCTCAAAGAGGAAGATGAACCTGCTTACAAAA GCTGCAAACAAGAGAATACCGCTTCTGGGAAGAAAGTCAGAAAATCACTAGTCTTAGATAATTGGGAAAAAGAAGAATCAGGCACTCAAC TGTTGACTGAAGACATTTCAGACATGCAGTCAGAAAATAGATTTACTACATCCTTATTAATGATACCATTATTGGAAATACATGACAATA GGTGCAACTTGATTCCTGAAAAACAAGATATAAATTCAACCAACAAAACATATACACTTACTAAAAAGAAACCAAACCCTAACACTTCCA AAGTTGTCAAATTGGAAAAGAATCTTCAGTCAAATTGTGAATGGGAAACAGTGGTTTATGGGAAGACAGAAGACCAACTTATTATGACTG AACAAGCAAGAAGATATCTGAGTACTTACACAGCTACCAGTAGTACTTCAAGAGCTCTCATACTGTAATTGTTATTAAAATTGATGAAAT GCCCCACTCCCTTACTGCAGTCTCTACTAAATTAGGTTGCAGTGAAATTTTTCTCAATTAGTTGTTTTTAAAGTTGTAAGATAGCCCTTT TAATACAGCATCTTTTTTCTATTCTATATAGTAGGCAGAAAGCTAGTAAGTCACTTAAGGGGTAGATAGTTTCATAGTTTATTTTTTAAG AGATGAGATTTTTAAAAATTGTTTTTAAAGAACAAGATGGGAAAATAATAGAATGTTCATGGATTTCTAAAAGTAAATTCTCATATATTT TCTTCACAAGATATATGTTGCTACTCTCTTGATGCTGCAGTTTTGTTATAGATAGGTGTATGAGTATATATGATTTCTGAAATTAGTCTA TGTATGGAAAGCACACATGATTTTATGAAGTACTTTTGCCCATGTGCTGATTTACTTAGGCTACCATTTACAAAGAAACACATTGAAAAG GAATTTAAAGGAAGGATAGAAAGTTGCACTACTAATTTTTTGTTTTTTTTTTCAGAAGCAGTAAAATTAACTACAGTGTTAAATGTATTT ATTTGAGCATAGTACTGAAAACAAAAAGCATTCAAAAAAGAGTTTTTTCTTTATTAGTAAATAGTATTTTCTTAATCTCAGAGGAGCTGA GAGTTTTGTTGAATGTATTGTACAGTATGTAGGAGCAGGAGAACTTTGTAAATTGGAAAGAAGTCTGTTTTTATAATTTATTTTTATTTT TAAAGCTTAAATGTAGATATTTATACGTATACAGGGTGCCTAGAAGCCAATGTTGTTTCCTGTTATTACAGCTAACACAGTAAAGAATAA TTTTGACTTTAAGTATGAAACAGTAGTAAGTTATAGCTGCAAAGAATACAATATCTATACTGTATGTCACATCTACCTAAATGTTGCACT ATGCCCTTTAAATCATGCTGGTTATAAAGTAGTTCTAAAAATGTACTAAATAATAATTTAATATTTTCTTTTTAAATTATATCGGGGGTG GTCATATACATTAATCTGGTGATTTGTATATGTGTTTGAAATTTTTGCATTTTGTTTAAAAAATAATATGGTACCTTGGTCCCTAAAAAC AGTCTGCACTTAGAAGTTTATATTTACTCAGTGTTTCAGAAGTGGAGAACATTATCTTTTATTTATAAAAATATTTTGTCCTTTTTTAAA TGTTTTGTGTTTCTCTACAGGTTACAACAGTTGCTTCAGTTGCCTGTTTTAGGTGTTTGCACTTATTTTATTTCTTCTTGAAAGAATTTT TATTTGCTTTTGTGGTAGAGATTATATGTAATTTTTTTTCAGTCATATAATGGTGTGCTGTCAACTTAAACACTGACAGGTAAATAGAAT TGTACACTGTAGTTTGAATTATTTATAATTGACACACTCTCTCCCTCTCCACTCCTGAAGTATGCTGCTATAGAAAATAGCAGAATCGGC TTGCTGCTACGAGAGAAGGAAAGAGCGACCACCACTTGCACTGTGTGAAAAGATAAAAAACAAATGATGGCAAGTTCTCAAGTTAACTAA ATGGAATCAACCATTACCAGGCAAATTCTTGCAAATACCAAAATACTACTATGCCTTATAAAACAAAATGAAAGCAGGTTAAGATTTTCT GCTCTGTTTGTATGTTAATAGAAATGGAAATACTAAGTATTTTAATGCTTAGCTCTTGAACAGTAGACCTAAAAGGGTTTTAAGCTATTT AAATCTACTTGCTAGTTTTTGCATATTTTATATATATATATATTTATATATATATATAGTGAGAAGTGAAGAAAATGTATGGTACTAAGA TTATGCCTTATTGATAAATAGATAAACCAATTTGAATCCTCTTAGCATGTTTAAGTATGTTGATTGCTTTCTAATTAATGAACTTCTCAC AGAAATTTCACTTAGTGAAACCAATGATTGTAGCAAACTCATACTGGATCATTTCAGTTACCTTGAACTAATAGCACATAATGGTTTTTT GTTGTTGTTGTTTTTAATGTAGCCCTTACCTGGATATACATAGTCTGCAATCACCAAAGTATAATATCTTGTAAGGCTATATTTTTTAAA GCATATTTTTTCTTGAGCATTAAATTATCCTAAATGGTAATATATTGTGGATAAGTCTGGGCTTATTGGACATAATACATATTTGGGTTG GTACTGGTTGAATCCTTCAGTTAACTGCTTTGTTGCTTTTTGCAAGATTTTTTATCTTAAACATGTCAGGCATCTTAAGTCACCTTTATA CTGTTTTGTTCCTCTGAGTTTCTTTCAGTATGTTATACAAATGCCAGACATAACATGTAGCAGCCATACTTGCATGGAAACTGACTACAC ATACATAATACTGCATTTTATTGTAAGGTTTTCACATTAATACAGCAATTACCCTGACTAAATTGAGTTTTGTGATATATGGAAAACTTC >In-frame_CA3_ENST00000285381_chr8_86356355_+_MYBL1_ENST00000517885_chr8_67479227_-_1083nt ACATAAAAGCGCGGGCTCGCGGCGACTCTGCACCACGCAGGGGAAGAGAAAGCAGGAGCCGTCCAGCACGGAGGAAGGCGACCATGGCCA AGGAGTGGGGCTACGCCAGTCACAACGGTCCTGACCACTGGCATGAACTTTTCCCAAATGCCAAGGGGGAAAACCAGTCGCCCGTTGAGC TGCATACTAAAGACATCAGGCATGACCCTTCTCTGCAGCCATGGTCTGTGTCTTATGATGGTGGCTCTGCCAAGACCATCCTGAATAATG GGAAGACCTGCCGAGTTGTATTTGATGATACTTATGATAGGTCAATGCTGAGAGGGGGTCCTCTCCCTGGACCCTACCGACTTCGCCAGT TTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCGTGGATGGAGTCAAGTATGCAGCGGAGCTTCATTTGGTTCACT GGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATGGGATCGCTGTGATTGGCATTTTTCTGAAGTCCCAGCCACTTG CTTTCTTGGAAGAAGATATTCGGGAAGTTTTAAAAGAAGAAACTGGAACAGACCTATTCCTCAAAGAGGAAGATGAACCTGCTTACAAAA GCTGCAAACAAGAGAATACCGCTTCTGGGAAGAAAGTCAGAAAATCACTAGTCTTAGATAATTGGGAAAAAGAAGAATCAGGCACTCAAC TGTTGACTGAAGACATTTCAGACATGCAGTCAGAAAATAGATTTACTACATCCTTATTAATGATACCATTATTGGAAATACATGACAATA GGTGCAACTTGATTCCTGAAAAACAAGATATAAATTCAACCAACAAAACATATACACTTACTAAAAAGAAACCAAACCCTAACACTTCCA AAGTTGTCAAATTGGAAAAGAATCTTCAGTCAAATTGTGAATGGGAAACAGTGGTTTATGGGAAGACAGAAGACCAACTTATTATGACTG AACAAGCAAGAAGATATCTGAGTACTTACACAGCTACCAGTAGTACTTCAAGAGCTCTCATACTGTAATTGTTATTAAAATTGATGAAAT >In-frame_CA3_ENST00000285381_chr8_86356355_+_MYBL1_ENST00000524176_chr8_67479227_-_878nt ACATAAAAGCGCGGGCTCGCGGCGACTCTGCACCACGCAGGGGAAGAGAAAGCAGGAGCCGTCCAGCACGGAGGAAGGCGACCATGGCCA AGGAGTGGGGCTACGCCAGTCACAACGGTCCTGACCACTGGCATGAACTTTTCCCAAATGCCAAGGGGGAAAACCAGTCGCCCGTTGAGC TGCATACTAAAGACATCAGGCATGACCCTTCTCTGCAGCCATGGTCTGTGTCTTATGATGGTGGCTCTGCCAAGACCATCCTGAATAATG GGAAGACCTGCCGAGTTGTATTTGATGATACTTATGATAGGTCAATGCTGAGAGGGGGTCCTCTCCCTGGACCCTACCGACTTCGCCAGT TTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCGTGGATGGAGTCAAGTATGCAGCGGAGCTTCATTTGGTTCACT GGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATGGGATCGCTGTGATTGGCATTTTTCTGAAGTCCCAGCCACTTG CTTTCTTGGAAGAAGATATTCGGGAAGTTTTAAAAGAAGAAACTGGAACAGACCTATTCCTCAAAGAGGAAGATGAACCTGCTTACAAAA GCTGCAAACAAGAGAATACCGCTTCTGGGAAGAAAGTCAGAAAATCACTAGTCTTAGATAATTGGGAAAAAGAAGAATCAGGCACTCAAC TGTTGACTGAAGACATTTCAGACATGCAGTCAAATTGTGAATGGGAAACAGTGGTTTATGGGAAGACAGAAGACCAACTTATTATGACTG |
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FusionGenePPI for CA3_MYBL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CA3 | BAG3, SRC | MYBL1 | NCL, NLK, HIPK2, CREBBP, LIN9, LIN37, LIN54, LIN52 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CA3_MYBL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CA3 | P07451 | DB00273 | Topiramate | Carbonic anhydrase 3 | small molecule | approved |
| Hgene | CA3 | P07451 | DB00703 | Methazolamide | Carbonic anhydrase 3 | small molecule | approved |
| Hgene | CA3 | P07451 | DB00869 | Dorzolamide | Carbonic anhydrase 3 | small molecule | approved |
| Hgene | CA3 | P07451 | DB01194 | Brinzolamide | Carbonic anhydrase 3 | small molecule | approved |
| Hgene | CA3 | P07451 | DB00391 | Sulpiride | Carbonic anhydrase 3 | small molecule | approved|investigational |
| Hgene | CA3 | P07451 | DB00482 | Celecoxib | Carbonic anhydrase 3 | small molecule | approved|investigational |
| Hgene | CA3 | P07451 | DB00909 | Zonisamide | Carbonic anhydrase 3 | small molecule | approved|investigational |
| Hgene | CA3 | P07451 | DB01144 | Diclofenamide | Carbonic anhydrase 3 | small molecule | approved|investigational |
| Hgene | CA3 | P07451 | DB00580 | Valdecoxib | Carbonic anhydrase 3 | small molecule | approved|investigational|withdrawn |
| Hgene | CA3 | P07451 | DB00819 | Acetazolamide | Carbonic anhydrase 3 | small molecule | approved|vet_approved |
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RelatedDiseases for CA3_MYBL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CA3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | CA3 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | CA3 | C0032273 | Pneumoconiosis | 1 | CTD_human |
| Tgene | MYBL1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | MYBL1 | C0017638 | Glioma | 1 | CTD_human |
| Tgene | MYBL1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
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