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Fusion gene ID: 5101 |
FusionGeneSummary for C8orf76_ATAD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C8orf76_ATAD2 | Fusion gene ID: 5101 | Hgene | Tgene | Gene symbol | C8orf76 | ATAD2 | Gene ID | 84933 | 29028 |
| Gene name | chromosome 8 open reading frame 76 | ATPase family, AAA domain containing 2 | |
| Synonyms | - | ANCCA|CT137|PRO2000 | |
| Cytomap | 8q24.13 | 8q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein C8orf76 | ATPase family AAA domain-containing protein 2AAA nuclear coregulator cancer-associated protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96K31 | Q6PL18 | |
| Ensembl transtripts involved in fusion gene | ENST00000276704, ENST00000521310, | ENST00000287394, ENST00000521903, ENST00000534257, | |
| Fusion gene scores | * DoF score | 2 X 3 X 4=24 | 6 X 6 X 7=252 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C8orf76 [Title/Abstract] AND ATAD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATAD2 | GO:0045893 | positive regulation of transcription, DNA-templated | 17998543 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-4Z-AA7Q-01A | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| TCGA | RV | KIRC | TCGA-BP-4962-01A | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| TCGA | RV | PRAD | TCGA-HC-7233-01A | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000276704 | ENST00000287394 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| In-frame | ENST00000276704 | ENST00000521903 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| 5CDS-intron | ENST00000276704 | ENST00000534257 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| In-frame | ENST00000521310 | ENST00000287394 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| In-frame | ENST00000521310 | ENST00000521903 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| 5CDS-intron | ENST00000521310 | ENST00000534257 | C8orf76 | chr8 | 124238740 | - | ATAD2 | chr8 | 124335306 | - |
| In-frame | ENST00000276704 | ENST00000287394 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| In-frame | ENST00000276704 | ENST00000521903 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| 5CDS-intron | ENST00000276704 | ENST00000534257 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| 5UTR-3CDS | ENST00000521310 | ENST00000287394 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| 5UTR-3CDS | ENST00000521310 | ENST00000521903 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| 5UTR-intron | ENST00000521310 | ENST00000534257 | C8orf76 | chr8 | 124250038 | - | ATAD2 | chr8 | 124351686 | - |
| Frame-shift | ENST00000276704 | ENST00000287394 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5CDS-intron | ENST00000276704 | ENST00000521903 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5CDS-intron | ENST00000276704 | ENST00000534257 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5UTR-3CDS | ENST00000521310 | ENST00000287394 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5UTR-intron | ENST00000521310 | ENST00000521903 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
| 5UTR-intron | ENST00000521310 | ENST00000534257 | C8orf76 | chr8 | 124253470 | - | ATAD2 | chr8 | 124361684 | - |
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FusionProtFeatures for C8orf76_ATAD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C8orf76 | ATAD2 |
| May be a transcriptional coactivator of the nuclearreceptor ESR1 required to induce the expression of a subset ofestradiol target genes, such as CCND1, MYC and E2F1. May play arole in the recruitment or occupancy of CREBBP at some ESR1 targetgene promoters. May be required for histone hyperacetylation.Involved in the estrogen-induced cell proliferation and cell cycleprogression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ATAD2 | chr8:124250038 | chr8:124351686 | ENST00000287394 | - | 18 | 28 | 1086_1112 | 906 | 1391 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >ATAD2 | chr8:124250038 | chr8:124351686 | ENST00000287394 | - | 18 | 28 | 970_994 | 906 | 1391 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >ATAD2 | chr8:124250038 | chr8:124351686 | ENST00000287394 | - | 18 | 28 | 1001_1071 | 906 | 1391 | Domain | Bromo |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ATAD2 | chr8:124238740 | chr8:124335306 | ENST00000287394 | - | 25 | 28 | 1086_1112 | 1334 | 1391 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | ATAD2 | chr8:124238740 | chr8:124335306 | ENST00000287394 | - | 25 | 28 | 970_994 | 1334 | 1391 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | ATAD2 | chr8:124238740 | chr8:124335306 | ENST00000287394 | - | 25 | 28 | 250_285 | 1334 | 1391 | Compositional bias | Note=Asp-rich |
| Tgene | ATAD2 | chr8:124238740 | chr8:124335306 | ENST00000287394 | - | 25 | 28 | 357_366 | 1334 | 1391 | Compositional bias | Note=Poly-Ser |
| Tgene | ATAD2 | chr8:124250038 | chr8:124351686 | ENST00000287394 | - | 18 | 28 | 250_285 | 906 | 1391 | Compositional bias | Note=Asp-rich |
| Tgene | ATAD2 | chr8:124250038 | chr8:124351686 | ENST00000287394 | - | 18 | 28 | 357_366 | 906 | 1391 | Compositional bias | Note=Poly-Ser |
| Tgene | ATAD2 | chr8:124238740 | chr8:124335306 | ENST00000287394 | - | 25 | 28 | 1001_1071 | 1334 | 1391 | Domain | Bromo |
| Tgene | ATAD2 | chr8:124238740 | chr8:124335306 | ENST00000287394 | - | 25 | 28 | 467_474 | 1334 | 1391 | Nucleotide binding | ATP |
| Tgene | ATAD2 | chr8:124250038 | chr8:124351686 | ENST00000287394 | - | 18 | 28 | 467_474 | 906 | 1391 | Nucleotide binding | ATP |
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FusionGeneSequence for C8orf76_ATAD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_C8orf76_ENST00000276704_chr8_124250038_-_ATAD2_ENST00000287394_chr8_124351686_-_604aa MDSGCWLFGGEFEDSVFEERPERRSGPPASYCAKLCEPQWFYEETESSDDVEVLTLKKFKGDLAYRRQEYQKALQEYSSISEKLSSTNFA MKRDVQEGQARCLAHLGRHMEALEIAANLVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEP RSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLIC SNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKL KTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIESDTEETQDTSVDHNETGNTGESSVEENEKQQNASESKL ELRNNSNTCNIENELEDSRKTTACTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILSQPTPSLV >In-frame_C8orf76_ENST00000276704_chr8_124250038_-_ATAD2_ENST00000521903_chr8_124351686_-_604aa MDSGCWLFGGEFEDSVFEERPERRSGPPASYCAKLCEPQWFYEETESSDDVEVLTLKKFKGDLAYRRQEYQKALQEYSSISEKLSSTNFA MKRDVQEGQARCLAHLGRHMEALEIAANLVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEP RSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLIC SNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKL KTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIESDTEETQDTSVDHNETGNTGESSVEENEKQQNASESKL ELRNNSNTCNIENELEDSRKTTACTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILSQPTPSLV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_C8orf76_ENST00000276704_chr8_124250038_-_ATAD2_ENST00000287394_chr8_124351686_-_1812nt ATGGATTCCGGGTGCTGGTTGTTCGGCGGCGAGTTCGAGGACTCGGTGTTCGAGGAGAGGCCGGAGCGGCGGTCAGGACCGCCCGCGTCC TACTGCGCCAAGCTCTGCGAGCCGCAGTGGTTTTATGAAGAAACAGAAAGCAGTGATGATGTTGAAGTGCTGACTCTCAAGAAATTCAAA GGAGACCTGGCCTACAGACGACAAGAGTATCAGAAAGCACTGCAGGAGTATTCCAGTATCTCTGAAAAATTGTCATCAACCAATTTTGCC ATGAAAAGGGATGTCCAGGAAGGTCAGGCTCGGTGTCTGGCTCACCTGGGTAGGCATATGGAGGCGCTGGAGATTGCTGCAAACTTGGTG CAAGAATTGTTTATCCGTGATTATGGAGAGATTTTTAATGTCCAGTTACCGGATAAAGAAGAACGGACAAAATTTTTTGAAGATTTAATT CTAAAACAAGCTGCTAAGCCTCCTATATCAAAAAAGAAAGCAGTTTTGCAGGCTTTGGAGGTACTCCCAGTAGCACCACCACCTGAGCCA AGATCACTGACAGCAGAAGAAGTGAAACGACTAGAAGAACAAGAAGAAGATACATTTAGAGAACTGAGGATTTTCTTAAGAAATGTTACA CATAGGCTTGCTATTGACAAGCGATTCCGAGTGTTTACTAAGCCTGTTGACCCTGATGAGGTTCCTGATTATGTCACTGTAATAAAGCAA CCAATGGACCTTTCATCTGTAATCAGTAAAATTGATCTACACAAGTATCTGACTGTGAAAGACTATTTGAGAGATATTGATCTAATCTGT AGTAATGCCTTAGAATACAATCCAGATAGAGATCCTGGAGATCGTCTTATTAGGCATAGAGCCTGTGCTTTAAGAGATACTGCCTATGCC ATAATTAAAGAAGAACTTGATGAAGACTTTGAGCAGCTCTGTGAAGAAATTCAGGAATCTAGAAAGAAAAGAGGTTGTAGCTCCTCCAAA TATGCCCCGTCTTACTACCATGTGATGCCAAAGCAAAATTCCACTCTTGTTGGTGATAAAAGATCAGACCCAGAGCAGAATGAAAAGCTA AAGACACCGAGTACTCCTGTGGCTTGCAGCACTCCTGCTCAGTTGAAGAGGAAAATTCGCAAAAAGTCAAACTGGTACTTAGGCACCATA AAAAAGCGAAGGAAGATTTCACAGGCAAAGGATGATAGCCAGAATGCCATAGATCACAAAATTGAGAGTGATACAGAGGAAACTCAAGAC ACAAGTGTAGATCATAATGAGACCGGAAACACAGGAGAGTCTTCGGTGGAAGAAAATGAAAAACAGCAAAATGCCTCTGAAAGCAAACTG GAATTGAGAAATAATTCAAATACTTGTAATATAGAGAATGAGCTTGAAGACTCTAGGAAGACTACAGCATGTACAGAATTGAGAGACAAG ATTGCTTGTAATGGAGATGCTTCTAGCTCTCAGATAATACATATTTCTGATGAAAATGAAGGAAAAGAAATGTGTGTTCTGCGAATGACT CGAGCTAGACGTTCCCAGGTAGAACAGCAGCAGCTCATCACTGTTGAAAAGGCTTTGGCAATTCTTTCTCAGCCTACACCCTCACTTGTT GTGGATCATGAGCGATTAAAAAATCTTTTGAAGACTGTTGTTAAAAAAAGTCAAAACTACAACATATTTCAGTTGGAAAATTTGTATGCA GTAATCAGCCAATGTATTTATCGGCATCGCAAGGACCATGATAAAACATCACTTATTCAGAAAATGGAGCAAGAGGTAGAAAACTTCAGT >In-frame_C8orf76_ENST00000276704_chr8_124250038_-_ATAD2_ENST00000521903_chr8_124351686_-_1812nt ATGGATTCCGGGTGCTGGTTGTTCGGCGGCGAGTTCGAGGACTCGGTGTTCGAGGAGAGGCCGGAGCGGCGGTCAGGACCGCCCGCGTCC TACTGCGCCAAGCTCTGCGAGCCGCAGTGGTTTTATGAAGAAACAGAAAGCAGTGATGATGTTGAAGTGCTGACTCTCAAGAAATTCAAA GGAGACCTGGCCTACAGACGACAAGAGTATCAGAAAGCACTGCAGGAGTATTCCAGTATCTCTGAAAAATTGTCATCAACCAATTTTGCC ATGAAAAGGGATGTCCAGGAAGGTCAGGCTCGGTGTCTGGCTCACCTGGGTAGGCATATGGAGGCGCTGGAGATTGCTGCAAACTTGGTG CAAGAATTGTTTATCCGTGATTATGGAGAGATTTTTAATGTCCAGTTACCGGATAAAGAAGAACGGACAAAATTTTTTGAAGATTTAATT CTAAAACAAGCTGCTAAGCCTCCTATATCAAAAAAGAAAGCAGTTTTGCAGGCTTTGGAGGTACTCCCAGTAGCACCACCACCTGAGCCA AGATCACTGACAGCAGAAGAAGTGAAACGACTAGAAGAACAAGAAGAAGATACATTTAGAGAACTGAGGATTTTCTTAAGAAATGTTACA CATAGGCTTGCTATTGACAAGCGATTCCGAGTGTTTACTAAGCCTGTTGACCCTGATGAGGTTCCTGATTATGTCACTGTAATAAAGCAA CCAATGGACCTTTCATCTGTAATCAGTAAAATTGATCTACACAAGTATCTGACTGTGAAAGACTATTTGAGAGATATTGATCTAATCTGT AGTAATGCCTTAGAATACAATCCAGATAGAGATCCTGGAGATCGTCTTATTAGGCATAGAGCCTGTGCTTTAAGAGATACTGCCTATGCC ATAATTAAAGAAGAACTTGATGAAGACTTTGAGCAGCTCTGTGAAGAAATTCAGGAATCTAGAAAGAAAAGAGGTTGTAGCTCCTCCAAA TATGCCCCGTCTTACTACCATGTGATGCCAAAGCAAAATTCCACTCTTGTTGGTGATAAAAGATCAGACCCAGAGCAGAATGAAAAGCTA AAGACACCGAGTACTCCTGTGGCTTGCAGCACTCCTGCTCAGTTGAAGAGGAAAATTCGCAAAAAGTCAAACTGGTACTTAGGCACCATA AAAAAGCGAAGGAAGATTTCACAGGCAAAGGATGATAGCCAGAATGCCATAGATCACAAAATTGAGAGTGATACAGAGGAAACTCAAGAC ACAAGTGTAGATCATAATGAGACCGGAAACACAGGAGAGTCTTCGGTGGAAGAAAATGAAAAACAGCAAAATGCCTCTGAAAGCAAACTG GAATTGAGAAATAATTCAAATACTTGTAATATAGAGAATGAGCTTGAAGACTCTAGGAAGACTACAGCATGTACAGAATTGAGAGACAAG ATTGCTTGTAATGGAGATGCTTCTAGCTCTCAGATAATACATATTTCTGATGAAAATGAAGGAAAAGAAATGTGTGTTCTGCGAATGACT CGAGCTAGACGTTCCCAGGTAGAACAGCAGCAGCTCATCACTGTTGAAAAGGCTTTGGCAATTCTTTCTCAGCCTACACCCTCACTTGTT GTGGATCATGAGCGATTAAAAAATCTTTTGAAGACTGTTGTTAAAAAAAGTCAAAACTACAACATATTTCAGTTGGAAAATTTGTATGCA GTAATCAGCCAATGTATTTATCGGCATCGCAAGGACCATGATAAAACATCACTTATTCAGAAAATGGAGCAAGAGGTAGAAAACTTCAGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_C8orf76_ENST00000276704_chr8_124250038_-_ATAD2_ENST00000287394_chr8_124351686_-_3148nt CCGCCTTTTCCGGCGGGCCCCGCTTCCTCGTTGCCCCCGCCGCGGGCGCGAGATGGATTCCGGGTGCTGGTTGTTCGGCGGCGAGTTCGA GGACTCGGTGTTCGAGGAGAGGCCGGAGCGGCGGTCAGGACCGCCCGCGTCCTACTGCGCCAAGCTCTGCGAGCCGCAGTGGTTTTATGA AGAAACAGAAAGCAGTGATGATGTTGAAGTGCTGACTCTCAAGAAATTCAAAGGAGACCTGGCCTACAGACGACAAGAGTATCAGAAAGC ACTGCAGGAGTATTCCAGTATCTCTGAAAAATTGTCATCAACCAATTTTGCCATGAAAAGGGATGTCCAGGAAGGTCAGGCTCGGTGTCT GGCTCACCTGGGTAGGCATATGGAGGCGCTGGAGATTGCTGCAAACTTGGTGCAAGAATTGTTTATCCGTGATTATGGAGAGATTTTTAA TGTCCAGTTACCGGATAAAGAAGAACGGACAAAATTTTTTGAAGATTTAATTCTAAAACAAGCTGCTAAGCCTCCTATATCAAAAAAGAA AGCAGTTTTGCAGGCTTTGGAGGTACTCCCAGTAGCACCACCACCTGAGCCAAGATCACTGACAGCAGAAGAAGTGAAACGACTAGAAGA ACAAGAAGAAGATACATTTAGAGAACTGAGGATTTTCTTAAGAAATGTTACACATAGGCTTGCTATTGACAAGCGATTCCGAGTGTTTAC TAAGCCTGTTGACCCTGATGAGGTTCCTGATTATGTCACTGTAATAAAGCAACCAATGGACCTTTCATCTGTAATCAGTAAAATTGATCT ACACAAGTATCTGACTGTGAAAGACTATTTGAGAGATATTGATCTAATCTGTAGTAATGCCTTAGAATACAATCCAGATAGAGATCCTGG AGATCGTCTTATTAGGCATAGAGCCTGTGCTTTAAGAGATACTGCCTATGCCATAATTAAAGAAGAACTTGATGAAGACTTTGAGCAGCT CTGTGAAGAAATTCAGGAATCTAGAAAGAAAAGAGGTTGTAGCTCCTCCAAATATGCCCCGTCTTACTACCATGTGATGCCAAAGCAAAA TTCCACTCTTGTTGGTGATAAAAGATCAGACCCAGAGCAGAATGAAAAGCTAAAGACACCGAGTACTCCTGTGGCTTGCAGCACTCCTGC TCAGTTGAAGAGGAAAATTCGCAAAAAGTCAAACTGGTACTTAGGCACCATAAAAAAGCGAAGGAAGATTTCACAGGCAAAGGATGATAG CCAGAATGCCATAGATCACAAAATTGAGAGTGATACAGAGGAAACTCAAGACACAAGTGTAGATCATAATGAGACCGGAAACACAGGAGA GTCTTCGGTGGAAGAAAATGAAAAACAGCAAAATGCCTCTGAAAGCAAACTGGAATTGAGAAATAATTCAAATACTTGTAATATAGAGAA TGAGCTTGAAGACTCTAGGAAGACTACAGCATGTACAGAATTGAGAGACAAGATTGCTTGTAATGGAGATGCTTCTAGCTCTCAGATAAT ACATATTTCTGATGAAAATGAAGGAAAAGAAATGTGTGTTCTGCGAATGACTCGAGCTAGACGTTCCCAGGTAGAACAGCAGCAGCTCAT CACTGTTGAAAAGGCTTTGGCAATTCTTTCTCAGCCTACACCCTCACTTGTTGTGGATCATGAGCGATTAAAAAATCTTTTGAAGACTGT TGTTAAAAAAAGTCAAAACTACAACATATTTCAGTTGGAAAATTTGTATGCAGTAATCAGCCAATGTATTTATCGGCATCGCAAGGACCA TGATAAAACATCACTTATTCAGAAAATGGAGCAAGAGGTAGAAAACTTCAGTTGTTCCAGATGATGATGTCATGGTATCGAGTATTCTTT ATATTCAGTTCCTATTTAAGTCATTTTTGTCATGTCCGCCTAATTGATGTAGTATGAAACCCTGCATCTTTAAGGAAAAGATTAAAATAG TAAAATAAAAGTATTTAAACTTTCCTGATATTTATGTACATATTAAGATAAATGTCATGTGTAAGATAACTGATAAATATTGGAACTTTG CTAGAACAAGACCCTGTAGTAATAGTAATAATAGTTGAAGTTTGGCCAACTCTTAATAAAGTTATTTTGGTAACTAATGTTTTATGGCAC TTAAGAATAATTAGCAGCGTTAAATTTTGTTTGTATTAAGCACTTTTAATTTTATCCTTCCTAAAAATAGTTTATTGTATCTGACAAGAA ACTTACTTAACCATTGTGTCCTTCCCATCTTTTTTGTCATCTTTGTTTTCTTCAAATGCCCTCCTCCCATCTGCCTTGAGATTCCCTCGT CTTCACTTAAAAGCCAGAGTGCAAGTCATGATTTGCGGGAGGGCTCTTGAACCACTTCTGGCTGCACCACAATTCTGTACTTGAGTATCA CAGTCATTGTTTTTGAGACAAACATTTTTATAATTCTAATTTGGGTTAATAAAGATTTTAAATATTTCTTGGTTTACTTTTGTAATTATA TACACAACAAATGTATTAATAACTACCTTGTTAAACACCTTTTAATAGCACAAGGTTTTTATATTTGCAAGCTGTTGATATCTTTCTAAA ACTGTTTAGGTTATAGTCTATTGATACTTTTTATATACAATTTTATAAATATAAATATTATAATTTTATATTAATGGTACCAAAAATACA TTTCTTAAGGTTAAAAGCATGCACTTCCATGCATACTTGCTTTTGGGGAGAGTGGGGAGAAGACATTCTAATAATCAGTTTGTGAAATAG CTTCTGTTGGAAACCTTTTGAGGGGAATAAGGAATGGTCATCTAAAATGAGAGATTCTGGATTTTAATGCAGTTCAAAGTTGAGCTGTAT TTTTGTTGTTGATTTATCTGGATTTTTTTTAAAGCCTTCTAAAACCCAGTGAATTCAATACCTTAATTAGTACATACTATCTTATGTAAT GCATAAAGCAATGCCAGTCACTGAGAACATTTAAATATATTTATATTCCTGGAGATACACATTCTCATTTTTGTTGGTTTATTATAAATT >In-frame_C8orf76_ENST00000276704_chr8_124250038_-_ATAD2_ENST00000521903_chr8_124351686_-_2496nt CCGCCTTTTCCGGCGGGCCCCGCTTCCTCGTTGCCCCCGCCGCGGGCGCGAGATGGATTCCGGGTGCTGGTTGTTCGGCGGCGAGTTCGA GGACTCGGTGTTCGAGGAGAGGCCGGAGCGGCGGTCAGGACCGCCCGCGTCCTACTGCGCCAAGCTCTGCGAGCCGCAGTGGTTTTATGA AGAAACAGAAAGCAGTGATGATGTTGAAGTGCTGACTCTCAAGAAATTCAAAGGAGACCTGGCCTACAGACGACAAGAGTATCAGAAAGC ACTGCAGGAGTATTCCAGTATCTCTGAAAAATTGTCATCAACCAATTTTGCCATGAAAAGGGATGTCCAGGAAGGTCAGGCTCGGTGTCT GGCTCACCTGGGTAGGCATATGGAGGCGCTGGAGATTGCTGCAAACTTGGTGCAAGAATTGTTTATCCGTGATTATGGAGAGATTTTTAA TGTCCAGTTACCGGATAAAGAAGAACGGACAAAATTTTTTGAAGATTTAATTCTAAAACAAGCTGCTAAGCCTCCTATATCAAAAAAGAA AGCAGTTTTGCAGGCTTTGGAGGTACTCCCAGTAGCACCACCACCTGAGCCAAGATCACTGACAGCAGAAGAAGTGAAACGACTAGAAGA ACAAGAAGAAGATACATTTAGAGAACTGAGGATTTTCTTAAGAAATGTTACACATAGGCTTGCTATTGACAAGCGATTCCGAGTGTTTAC TAAGCCTGTTGACCCTGATGAGGTTCCTGATTATGTCACTGTAATAAAGCAACCAATGGACCTTTCATCTGTAATCAGTAAAATTGATCT ACACAAGTATCTGACTGTGAAAGACTATTTGAGAGATATTGATCTAATCTGTAGTAATGCCTTAGAATACAATCCAGATAGAGATCCTGG AGATCGTCTTATTAGGCATAGAGCCTGTGCTTTAAGAGATACTGCCTATGCCATAATTAAAGAAGAACTTGATGAAGACTTTGAGCAGCT CTGTGAAGAAATTCAGGAATCTAGAAAGAAAAGAGGTTGTAGCTCCTCCAAATATGCCCCGTCTTACTACCATGTGATGCCAAAGCAAAA TTCCACTCTTGTTGGTGATAAAAGATCAGACCCAGAGCAGAATGAAAAGCTAAAGACACCGAGTACTCCTGTGGCTTGCAGCACTCCTGC TCAGTTGAAGAGGAAAATTCGCAAAAAGTCAAACTGGTACTTAGGCACCATAAAAAAGCGAAGGAAGATTTCACAGGCAAAGGATGATAG CCAGAATGCCATAGATCACAAAATTGAGAGTGATACAGAGGAAACTCAAGACACAAGTGTAGATCATAATGAGACCGGAAACACAGGAGA GTCTTCGGTGGAAGAAAATGAAAAACAGCAAAATGCCTCTGAAAGCAAACTGGAATTGAGAAATAATTCAAATACTTGTAATATAGAGAA TGAGCTTGAAGACTCTAGGAAGACTACAGCATGTACAGAATTGAGAGACAAGATTGCTTGTAATGGAGATGCTTCTAGCTCTCAGATAAT ACATATTTCTGATGAAAATGAAGGAAAAGAAATGTGTGTTCTGCGAATGACTCGAGCTAGACGTTCCCAGGTAGAACAGCAGCAGCTCAT CACTGTTGAAAAGGCTTTGGCAATTCTTTCTCAGCCTACACCCTCACTTGTTGTGGATCATGAGCGATTAAAAAATCTTTTGAAGACTGT TGTTAAAAAAAGTCAAAACTACAACATATTTCAGTTGGAAAATTTGTATGCAGTAATCAGCCAATGTATTTATCGGCATCGCAAGGACCA TGATAAAACATCACTTATTCAGAAAATGGAGCAAGAGGTAGAAAACTTCAGTTGTTCCAGATGATGATGTCATGGTATCGAGTATTCTTT ATATTCAGTTCCTATTTAAGTCATTTTTGTCATGTCCGCCTAATTGATGTAGTATGAAACCCTGCATCTTTAAGGAAAAGATTAAAATAG TAAAATAAAAGTATTTAAACTTTCCTGATATTTATGTACATATTAAGATAAATGTCATGTGTAAGATAACTGATAAATATTGGAACTTTG CTAGAACAAGACCCTGTAGTAATAGTAATAATAGTTGAAGTTTGGCCAACTCTTAATAAAGTTATTTTGGTAACTAATGTTTTATGGCAC TTAAGAATAATTAGCAGCGTTAAATTTTGTTTGTATTAAGCACTTTTAATTTTATCCTTCCTAAAAATAGTTTATTGTATCTGACAAGAA ACTTACTTAACCATTGTGTCCTTCCCATCTTTTTTGTCATCTTTGTTTTCTTCAAATGCCCTCCTCCCATCTGCCTTGAGATTCCCTCGT CTTCACTTAAAAGCCAGAGTGCAAGTCATGATTTGCGGGAGGGCTCTTGAACCACTTCTGGCTGCACCACAATTCTGTACTTGAGTATCA |
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FusionGenePPI for C8orf76_ATAD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| C8orf76 | NOTCH3 | ATAD2 | MYC, NCOA3, ESR1, E2F1, E2F3, E2F4, E2F2, HIST3H3, HIST2H4A, SIRT7, HDAC11, NXF1, POLE3, IFI16, BAG4, BCAR3, CASP8, HIST1H2BG, HIST1H3A, SPTBN2, TRIM25, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C8orf76_ATAD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C8orf76_ATAD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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