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Fusion gene ID: 5086 |
FusionGeneSummary for C7orf50_CD177 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C7orf50_CD177 | Fusion gene ID: 5086 | Hgene | Tgene | Gene symbol | C7orf50 | CD177 | Gene ID | 84310 | 57126 |
| Gene name | chromosome 7 open reading frame 50 | CD177 molecule | |
| Synonyms | YCR016W | HNA-2a|HNA2A|NB1|NB1 GP|PRV-1|PRV1 | |
| Cytomap | 7p22.3 | 19q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein C7orf50 | CD177 antigenNB1 glycoproteincell surface receptorhuman neutrophil alloantigen 2apolycythemia rubra vera protein 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9BRJ6 | Q8N6Q3 | |
| Ensembl transtripts involved in fusion gene | ENST00000357429, ENST00000397100, ENST00000397098, ENST00000488073, | ENST00000607517, ENST00000378012, ENST00000378009, | |
| Fusion gene scores | * DoF score | 7 X 4 X 7=196 | 3 X 2 X 3=18 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/196*10)=-0.970853654340483 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: C7orf50 [Title/Abstract] AND CD177 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CD177 | GO:0030100 | regulation of endocytosis | 28807980 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-B9-A44B-01A | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000357429 | ENST00000607517 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| In-frame | ENST00000357429 | ENST00000378012 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| In-frame | ENST00000357429 | ENST00000378009 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397100 | ENST00000607517 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397100 | ENST00000378012 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397100 | ENST00000378009 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397098 | ENST00000607517 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397098 | ENST00000378012 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| Frame-shift | ENST00000397098 | ENST00000378009 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| 5UTR-3CDS | ENST00000488073 | ENST00000607517 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| 5UTR-3CDS | ENST00000488073 | ENST00000378012 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
| 5UTR-3CDS | ENST00000488073 | ENST00000378009 | C7orf50 | chr7 | 1166893 | - | CD177 | chr19 | 43858005 | + |
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FusionProtFeatures for C7orf50_CD177 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C7orf50 | CD177 |
| In association with beta-2 integrin heterodimerITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alphaprimed neutrophils including degranulation and superoxideproduction (PubMed:21193407). In addition, by preventing beta-2integrin internalization and attenuating chemokine signalingfavors adhesion over migration (PubMed:28807980). Heterophilicinteraction with PECAM1 on endothelial cells plays a role inneutrophil transendothelial migration in vitro (PubMed:17580308).However, appears to be dispensable for neutrophil recruitmentcaused by bacterial infection in vivo (PubMed:23461681). Acts as areceptor for the mature form of protease PRTN3 allowing itsdisplay at the cell surface of neutrophils (PubMed:17244676,PubMed:18462208). By displaying PRTN3 at the neutrophil cellsurface, may play a role in enhancing endothelial cell junctionalintegrity and thus vascular integrity during neutrophil diapedesis(PubMed:23202369). {ECO:0000269|PubMed:17244676,ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208,ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23202369,ECO:0000269|PubMed:23461681, ECO:0000269|PubMed:28807980}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CD177 | chr7:1166893 | chr19:43858005 | ENST00000378012 | + | 0 | 4 | 133_210 | 17 | 146 | Domain | Note=UPAR/Ly6 1 |
| Tgene | >CD177 | chr7:1166893 | chr19:43858005 | ENST00000378012 | + | 0 | 4 | 325_377 | 17 | 146 | Domain | Note=UPAR/Ly6 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C7orf50_CD177 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_C7orf50_ENST00000357429_chr7_1166893_-_CD177_ENST00000607517_chr19_43858005_+_463aa MAKQKRKVPEVTEKKNKKLKKASAEGPLLGPEAAPSGEGAGSKECRRCSASLGQFSMCGRCPTCPGNGPLRTPAATAAWGARTRXCSLRA DPKXAWCSPRAARRPRTRSPASLSTGWAPASPXSPTPSCAARRTSATTSLTPSRFGPHSPQQTQDPXGAQSACLWKAVWRGQQKRSAPRG PHTVMMASSGSGEEASSPIXESRDACPSQFATCSMGHRKLGPWVXLRTAIXKIFXPVIGGPPLXHTETWLKNPLIGPHRIPRCARWGRCV RRRCCSXMXDSHQPWWRPKAAALLGLKIPRRPPSTQPLLGCLWPPIPTSAPRTCAIVPAAAAFCXTPSLLKLPLSQETGSVLPVCSPLEP VQVAPPEXPAPGAPLIVMMGTFISQEVGCPPKXAFRAAWPNLPASCXTTPDKSGSSLRVRSVMCSLLPLSMREVGLRAWSLSLGGWGWHW >In-frame_C7orf50_ENST00000357429_chr7_1166893_-_CD177_ENST00000378012_chr19_43858005_+_171aa MAKQKRKVPEVTEKKNKKLKKASAEGPLLGPEAAPSGEGAGSKECRRCSASLGQFSMCGRCPTCPGNGPLRTPAATAAWGARTRXCSLRA >In-frame_C7orf50_ENST00000357429_chr7_1166893_-_CD177_ENST00000378009_chr19_43858005_+_274aa MAKQKRKVPEVTEKKNKKLKKASAEGPLLGPEAAPSGEGAGSKECRRCSASLGQFSMCGRCPTCPGNGPLRTPAATAAWGARTRXCSLRA DPKXAWCSPRAARRPRTRSPASLSTGWAPASPXSPTPSCAARRTSATTSLTPSRFGPHSPQQTQDPXGAQSACLWKAVWRGQQKRSAPRG PHTVMMASSGSGEEASSPIXESRDACPSQFATCSMGHRKLGPWVXLRTAIXKIFCSSSQXDYLRNTMWERKSVVKDNTNVFSXTGRNEPP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_C7orf50_ENST00000357429_chr7_1166893_-_CD177_ENST00000607517_chr19_43858005_+_1391nt ATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGC CCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGAGTGCAGGCGCTGCTCTGCCAGTTTGGGACAGTTCAGCATGTGTGGAAGG TGTCCGACCTGCCCCGGCAATGGACCCCTAAGAACACCAGCTGCGACAGCGGCTTGGGGTGCCAGGACACGTTGATGCTCATTGAGAGCG GACCCCAAGTGAGCCTGGTGCTCTCCAAGGGCTGCACGGAGGCCAAGGACCAGGAGCCCCGCGTCACTGAGCACCGGATGGGCCCCGGCC TCTCCCTGATCTCCTACACCTTCGTGTGCCGCCAGGAGGACTTCTGCAACAACCTCGTTAACTCCCTCCCGCTTTGGGCCCCACAGCCCC CAGCAGACCCAGGATCCTTGAGGTGCCCAGTCTGCTTGTCTATGGAAGGCTGTCTGGAGGGGACAACAGAAGAGATCTGCCCCAAGGGGA CCACACACTGTTATGATGGCCTCCTCAGGCTCAGGGGAGGAGGCATCTTCTCCAATCTGAGAGTCCAGGGATGCATGCCCCAGCCAGTTT GCAACCTGCTCAATGGGACACAGGAAATTGGGCCCGTGGGTATGACTGAGAACTGCGATATGAAAGATTTTCTGACCTGTCATCGGGGGA CCACCATTATGACACACGGAAACTTGGCTCAAGAACCCACTGATTGGACCACATCGAATACCGAGATGTGCGAGGTGGGGCAGGTGTGTC AGGAGACGCTGCTGCTCCTAGATGTAGGACTCACATCAACCCTGGTGGCGACCTAAAGCTGCAGCGCTGTTGGGGCTCAAAATTCCCAGA AGACCACCATCCACTCAGCCCCTCCTGGGGTGCTTGTGGCCTCCTATACCCACTTCTGCTCCTCGGACCTGTGCAATAGTGCCAGCAGCA GCAGCGTTCTGCTGAACTCCCTCCCTCCTCAAGCTGCCCCTGTCCCAGGAGACCGGCAGTGTCCTACCTGTGTGCAGCCCCTTGGAACCT GTTCAAGTGGCTCCCCCCGAATGACCTGCCCCAGGGGCGCCACTCATTGTTATGATGGGTACATTCATCTCTCAGGAGGTGGGCTGTCCA CCAAAATGAGCATTCAGGGCTGCGTGGCCCAACCTTCCAGCTTCTTGTTGAACCACACCAGACAAATCGGGATCTTCTCTGCGCGTGAGA AGCGTGATGTGCAGCCTCCTGCCTCTCAGCATGAGGGAGGTGGGGCTGAGGGCCTGGAGTCTCTCACTTGGGGGGTGGGGCTGGCACTGG >In-frame_C7orf50_ENST00000357429_chr7_1166893_-_CD177_ENST00000378012_chr19_43858005_+_515nt ATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGC CCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGAGTGCAGGCGCTGCTCTGCCAGTTTGGGACAGTTCAGCATGTGTGGAAGG TGTCCGACCTGCCCCGGCAATGGACCCCTAAGAACACCAGCTGCGACAGCGGCTTGGGGTGCCAGGACACGTTGATGCTCATTGAGAGCG GACCCCAAGTGAGCCTGGTGCTCTCCAAGGGCTGCACGGAGGCCAAGGACCAGGAGCCCCGCGTCACTGAGCACCGGATGGGCCCCGGCC TCTCCCTGATCTCCTACACCTTCGTGTGCCGCCAGGAGGACTTCTGCAACAACCTCGTTAACTCCCTCCCGCTTTGGGCCCCACAGCCCC >In-frame_C7orf50_ENST00000357429_chr7_1166893_-_CD177_ENST00000378009_chr19_43858005_+_824nt ATGGCAAAACAGAAGAGAAAAGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGC CCTGAGGCTGCACCAAGTGGCGAAGGAGCCGGCTCCAAGGAGTGCAGGCGCTGCTCTGCCAGTTTGGGACAGTTCAGCATGTGTGGAAGG TGTCCGACCTGCCCCGGCAATGGACCCCTAAGAACACCAGCTGCGACAGCGGCTTGGGGTGCCAGGACACGTTGATGCTCATTGAGAGCG GACCCCAAGTGAGCCTGGTGCTCTCCAAGGGCTGCACGGAGGCCAAGGACCAGGAGCCCCGCGTCACTGAGCACCGGATGGGCCCCGGCC TCTCCCTGATCTCCTACACCTTCGTGTGCCGCCAGGAGGACTTCTGCAACAACCTCGTTAACTCCCTCCCGCTTTGGGCCCCACAGCCCC CAGCAGACCCAGGATCCTTGAGGTGCCCAGTCTGCTTGTCTATGGAAGGCTGTCTGGAGGGGACAACAGAAGAGATCTGCCCCAAGGGGA CCACACACTGTTATGATGGCCTCCTCAGGCTCAGGGGAGGAGGCATCTTCTCCAATCTGAGAGTCCAGGGATGCATGCCCCAGCCAGTTT GCAACCTGCTCAATGGGACACAGGAAATTGGGCCCGTGGGTATGACTGAGAACTGCGATATGAAAGATTTTCTGCAGCTCAAGCCAGTAG GATTACTTGAGGAACACAATGTGGGAGAGAAAGAGCGTGGTCAAGGACAACACCAATGTGTTCAGCTAGACTGGCAGAAACGAGCCGCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_C7orf50_ENST00000357429_chr7_1166893_-_CD177_ENST00000607517_chr19_43858005_+_2313nt GCCGGAAGGCGGCGTCCGCGACGCAGCTGTTCACGCTTAGGTGGGCGACGTGGGCGCAGGTGGGCGCAGGATGGCAAAACAGAAGAGAAA AGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGG CGAAGGAGCCGGCTCCAAGGAGTGCAGGCGCTGCTCTGCCAGTTTGGGACAGTTCAGCATGTGTGGAAGGTGTCCGACCTGCCCCGGCAA TGGACCCCTAAGAACACCAGCTGCGACAGCGGCTTGGGGTGCCAGGACACGTTGATGCTCATTGAGAGCGGACCCCAAGTGAGCCTGGTG CTCTCCAAGGGCTGCACGGAGGCCAAGGACCAGGAGCCCCGCGTCACTGAGCACCGGATGGGCCCCGGCCTCTCCCTGATCTCCTACACC TTCGTGTGCCGCCAGGAGGACTTCTGCAACAACCTCGTTAACTCCCTCCCGCTTTGGGCCCCACAGCCCCCAGCAGACCCAGGATCCTTG AGGTGCCCAGTCTGCTTGTCTATGGAAGGCTGTCTGGAGGGGACAACAGAAGAGATCTGCCCCAAGGGGACCACACACTGTTATGATGGC CTCCTCAGGCTCAGGGGAGGAGGCATCTTCTCCAATCTGAGAGTCCAGGGATGCATGCCCCAGCCAGTTTGCAACCTGCTCAATGGGACA CAGGAAATTGGGCCCGTGGGTATGACTGAGAACTGCGATATGAAAGATTTTCTGACCTGTCATCGGGGGACCACCATTATGACACACGGA AACTTGGCTCAAGAACCCACTGATTGGACCACATCGAATACCGAGATGTGCGAGGTGGGGCAGGTGTGTCAGGAGACGCTGCTGCTCCTA GATGTAGGACTCACATCAACCCTGGTGGCGACCTAAAGCTGCAGCGCTGTTGGGGCTCAAAATTCCCAGAAGACCACCATCCACTCAGCC CCTCCTGGGGTGCTTGTGGCCTCCTATACCCACTTCTGCTCCTCGGACCTGTGCAATAGTGCCAGCAGCAGCAGCGTTCTGCTGAACTCC CTCCCTCCTCAAGCTGCCCCTGTCCCAGGAGACCGGCAGTGTCCTACCTGTGTGCAGCCCCTTGGAACCTGTTCAAGTGGCTCCCCCCGA ATGACCTGCCCCAGGGGCGCCACTCATTGTTATGATGGGTACATTCATCTCTCAGGAGGTGGGCTGTCCACCAAAATGAGCATTCAGGGC TGCGTGGCCCAACCTTCCAGCTTCTTGTTGAACCACACCAGACAAATCGGGATCTTCTCTGCGCGTGAGAAGCGTGATGTGCAGCCTCCT GCCTCTCAGCATGAGGGAGGTGGGGCTGAGGGCCTGGAGTCTCTCACTTGGGGGGTGGGGCTGGCACTGGCCCCAGCGCTGTGGTGGGGA GTGGTTTGCCCTTCCTGCTAACTCTATTACCCCCACGATTCTTCACCGCTGCTGACCACCCACACTCAACCTCCCTCTGACCTCATAACC TAATGGCCTTGGACACCAGATTCTTTCCCATTCTGTCCATGAATCATCTTCCCCACACACAATCATTCATATCTACTCACCTAACAGCAA CACTGGGGAGAGCCTGGAGCATCCGGACTTGCCCTATGGGAGAGGGGACGCTGGAGGAGTGGCTGCATGTATCTGATAATACAGACCCTG TCCTTTCTCCCAGTGCTGGGATTTCTCCATGTGAGGGGGCAGCAGGACACCCAGGGATCTAGCGTGGGGGAGGAGAGGAGCCTAATGAGA AAATGACCATCTAAAGCCTGCCCTTCATTGGTCTGGTTCACGTCTCCAAACCAGCTTGGATGGTAGCAGAGACTTCAGGGTGCTCCAGCC AAACGTATTTGGGCATCACCATGACCTGGGAGGGGAAGATGCACTGAGACGTATGAGGCTTCCAGCCTAGCAGCCAGGGCCCTAGCACAA ACAGGAGGCTCGCCCCATCTGAGCAACTGCAGGAGAGGTTAGTACAGTCATGCATTGCTTAACGACAGGGACGTGTCGTTAGAAATGTGT CGTTAGGTGATTTTATGACCATAGGAACATTGTAGCGTGCACTTACACCAACCCAGATGGTACAGCCCAATACACACCCAGGATGGACGC TAGAGTCGACTGCTCCTAGGCTACAAGCCTGCAGTGCATGTTATGGTGTGAATACTGCAGGCAATCTTAACACCACGGCAAGTATTTGTG >In-frame_C7orf50_ENST00000357429_chr7_1166893_-_CD177_ENST00000378012_chr19_43858005_+_585nt GCCGGAAGGCGGCGTCCGCGACGCAGCTGTTCACGCTTAGGTGGGCGACGTGGGCGCAGGTGGGCGCAGGATGGCAAAACAGAAGAGAAA AGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGG CGAAGGAGCCGGCTCCAAGGAGTGCAGGCGCTGCTCTGCCAGTTTGGGACAGTTCAGCATGTGTGGAAGGTGTCCGACCTGCCCCGGCAA TGGACCCCTAAGAACACCAGCTGCGACAGCGGCTTGGGGTGCCAGGACACGTTGATGCTCATTGAGAGCGGACCCCAAGTGAGCCTGGTG CTCTCCAAGGGCTGCACGGAGGCCAAGGACCAGGAGCCCCGCGTCACTGAGCACCGGATGGGCCCCGGCCTCTCCCTGATCTCCTACACC TTCGTGTGCCGCCAGGAGGACTTCTGCAACAACCTCGTTAACTCCCTCCCGCTTTGGGCCCCACAGCCCCCAGCAGATCCCATGATGGGA >In-frame_C7orf50_ENST00000357429_chr7_1166893_-_CD177_ENST00000378009_chr19_43858005_+_2588nt GCCGGAAGGCGGCGTCCGCGACGCAGCTGTTCACGCTTAGGTGGGCGACGTGGGCGCAGGTGGGCGCAGGATGGCAAAACAGAAGAGAAA AGTTCCTGAAGTGACAGAGAAAAAGAACAAAAAGCTGAAGAAGGCGTCAGCAGAGGGGCCACTGCTGGGCCCTGAGGCTGCACCAAGTGG CGAAGGAGCCGGCTCCAAGGAGTGCAGGCGCTGCTCTGCCAGTTTGGGACAGTTCAGCATGTGTGGAAGGTGTCCGACCTGCCCCGGCAA TGGACCCCTAAGAACACCAGCTGCGACAGCGGCTTGGGGTGCCAGGACACGTTGATGCTCATTGAGAGCGGACCCCAAGTGAGCCTGGTG CTCTCCAAGGGCTGCACGGAGGCCAAGGACCAGGAGCCCCGCGTCACTGAGCACCGGATGGGCCCCGGCCTCTCCCTGATCTCCTACACC TTCGTGTGCCGCCAGGAGGACTTCTGCAACAACCTCGTTAACTCCCTCCCGCTTTGGGCCCCACAGCCCCCAGCAGACCCAGGATCCTTG AGGTGCCCAGTCTGCTTGTCTATGGAAGGCTGTCTGGAGGGGACAACAGAAGAGATCTGCCCCAAGGGGACCACACACTGTTATGATGGC CTCCTCAGGCTCAGGGGAGGAGGCATCTTCTCCAATCTGAGAGTCCAGGGATGCATGCCCCAGCCAGTTTGCAACCTGCTCAATGGGACA CAGGAAATTGGGCCCGTGGGTATGACTGAGAACTGCGATATGAAAGATTTTCTGCAGCTCAAGCCAGTAGGATTACTTGAGGAACACAAT GTGGGAGAGAAAGAGCGTGGTCAAGGACAACACCAATGTGTTCAGCTAGACTGGCAGAAACGAGCCGCCACGGGTATTTTCTGACCTGTC ATCGGGGGACCACCATTATGACACACGGAAACTTGGCTCAAGAACCCACTGATTGGACCACATCGAATACCGAGATGTGCGAGGTGGGGC AGGTGTGTCAGGAGACGCTGCTGCTCCTAGATGTAGGACTCACATCAACCCTGGTGGCGACCTAAAGCTGCAGCGCTGTTGGGGCTCAAA ATTCCCAGAAGACCACCATCCACTCAGCCCCTCCTGGGGTGCTTGTGGCCTCCTATACCCACTTCTGCTCCTCGGACCTGTGCAATAGTG CCAGCAGCAGCAGCGTTCTGCTGAACTCCCTCCCTCCTCAAGCTGCCCCTGTCCCAGGAGACCGGCAGTGTCCTACCTGTGTGCAGCCCC TTGGAACCTGTTCAAGTGGCTCCCCCCGAATGACCTGCCCCAGGGGCGCCACTCATTGTTATGATGGGTACATTCATCTCTCAGGAGGTG GGCTGTCCACCAAAATGAGCATTCAGGGCTGCGTGGCCCAACCTTCCAGCTTCTTGTTGAACCACACCAGACAAATCGGGATCTTCTCTG CGCGTGAGAAGCGTGATGTGCAGCCTCCTGCCTCTCAGCATGAGGGAGGTGGGGCTGAGGGCCTGGAGTCTCTCACTTGGGGGGTGGGGC TGGCACTGGCCCCAGCGCTGTGGTGGGGAGTGGTTTGCCCTTCCTGCTAACTCTATTACCCCCACGATTCTTCACCGCTGCTGACCACCC ACACTCAACCTCCCTCTGACCTCATAACCTAATGGCCTTGGACACCAGATTCTTTCCCATTCTGTCCATGAATCATCTTCCCCACACACA ATCATTCATATCTACTCACCTAACAGCAACACTGGGGAGAGCCTGGAGCATCCGGACTTGCCCTATGGGAGAGGGGACGCTGGAGGAGTG GCTGCATGTATCTGATAATACAGACCCTGTCCTTTCTCCCAGTGCTGGGATTTCTCCATGTGAGGGGGCAGCAGGACACCCAGGGATCTA GCGTGGGGGAGGAGAGGAGCCTAATGAGAAAATGACCATCTAAAGCCTGCCCTTCATTGGTCTGGTTCACGTCTCCAAACCAGCTTGGAT GGTAGCAGAGACTTCAGGGTGCTCCAGCCAAACGTATTTGGGCATCACCATGACCTGGGAGGGGAAGATGCACTGAGACGTATGAGGCTT CCAGCCTAGCAGCCAGGGCCCTAGCACAAACAGGAGGCTCGCCCCATCTGAGCAACTGCAGGAGAGGTTAGTACAGTCATGCATTGCTTA ACGACAGGGACGTGTCGTTAGAAATGTGTCGTTAGGTGATTTTATGACCATAGGAACATTGTAGCGTGCACTTACACCAACCCAGATGGT ACAGCCCAATACACACCCAGGATGGACGCTAGAGTCGACTGCTCCTAGGCTACAAGCCTGCAGTGCATGTTATGGTGTGAATACTGCAGG CAATCTTAACACCACGGCAAGTATTTGTGCATCTACACACATCTAAACATAGAAAAGGTACAGCATAAATACACTATTGTCATCTCAGCA GACCACCGTTCTATACGCAATTCGTCGCTGACCCAAACGTTGCTATGTAGCATCTGCGTATCGTGGGATAATTGACATGAGGGCTTGAGA |
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FusionGenePPI for C7orf50_CD177 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| C7orf50 | CCDC85B, NEDD4L, HDGF, CUL1, COPS5, CAND1, PRNP, APP, PAXIP1, FBXO25, RPA3, RPA2, RPA1, ADARB1, THAP1, RNF2, HIST1H1A, RPL8, THAP7, PRR11, NTRK1, PCNT, NOP56, NCL, CYLD, TRIM25 | CD177 | EWSR1, KCNIP3, SHBG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C7orf50_CD177 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C7orf50_CD177 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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