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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5078

FusionGeneSummary for C7orf25_RALB

check button Fusion gene summary
Fusion gene informationFusion gene name: C7orf25_RALB
Fusion gene ID: 5078
HgeneTgene
Gene symbol

C7orf25

RALB

Gene ID

79020

5899

Gene namechromosome 7 open reading frame 25RAS like proto-oncogene B
Synonyms--
Cytomap

7p14.1

2q14.2

Type of geneprotein-codingprotein-coding
DescriptionUPF0415 protein C7orf25ras-related protein Ral-BRALB Ras like proto-oncogene BRAS-like protein Bras related GTP binding protein Bv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
Modification date2018051920180522
UniProtAcc

Q9BPX7

P11234

Ensembl transtripts involved in fusion geneENST00000350427, ENST00000447342, 
ENST00000431882, ENST00000438029, 
ENST00000474855, ENST00000272519, 
ENST00000420510, ENST00000404963, 
ENST00000470417, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C7orf25 [Title/Abstract] AND RALB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRALB

GO:0009267

cellular response to starvation

24056301


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI190624C7orf25chr7

42956724

+RALBchr2

121052136

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000350427ENST00000474855C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000350427ENST00000272519C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-intronENST00000350427ENST00000420510C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000350427ENST00000404963C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000350427ENST00000470417C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-intronENST00000447342ENST00000474855C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000447342ENST00000272519C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-intronENST00000447342ENST00000420510C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000447342ENST00000404963C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000447342ENST00000470417C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-intronENST00000431882ENST00000474855C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000431882ENST00000272519C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-intronENST00000431882ENST00000420510C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000431882ENST00000404963C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000431882ENST00000470417C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-intronENST00000438029ENST00000474855C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000438029ENST00000272519C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-intronENST00000438029ENST00000420510C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000438029ENST00000404963C7orf25chr7

42956724

+RALBchr2

121052136

-
intron-3UTRENST00000438029ENST00000470417C7orf25chr7

42956724

+RALBchr2

121052136

-

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FusionProtFeatures for C7orf25_RALB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C7orf25

Q9BPX7

RALB

P11234

Multifunctional GTPase involved in a variety of cellularprocesses including gene expression, cell migration, cellproliferation, oncogenic transformation and membrane trafficking.Accomplishes its multiple functions by interacting with distinctdownstream effectors. Acts as a GTP sensor for GTP-dependentexocytosis of dense core vesicles (By similarity). Required bothto stabilize the assembly of the exocyst complex and to localizefunctional exocyst complexes to the leading edge of migratingcells (By similarity). Required for suppression of apoptosis(PubMed:17875936). In late stages of cytokinesis, upon completionof the bridge formation between dividing cells, mediates exocystrecruitment to the midbody to drive abscission (PubMed:18756269).{ECO:0000250|UniProtKB:P36860, ECO:0000269|PubMed:17875936,ECO:0000269|PubMed:18756269}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C7orf25_RALB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C7orf25_RALB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C7orf25_RALB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C7orf25_RALB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource