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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5056

FusionGeneSummary for C6orf48_B2M

check button Fusion gene summary
Fusion gene informationFusion gene name: C6orf48_B2M
Fusion gene ID: 5056
HgeneTgene
Gene symbol

C6orf48

B2M

Gene ID

50854

567

Gene namechromosome 6 open reading frame 48beta-2-microglobulin
SynonymsD6S57|G8IMD43
Cytomap

6p21.33

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein G8beta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin
Modification date2018051920180523
UniProtAcc

Q9UBA6

P61769

Ensembl transtripts involved in fusion geneENST00000375640, ENST00000375641, 
ENST00000375638, ENST00000375635, 
ENST00000375639, ENST00000375642, 
ENST00000395789, ENST00000375633, 
ENST00000395788, ENST00000424962, 
ENST00000456268, ENST00000435938, 
ENST00000433752, ENST00000458514, 
ENST00000549426, ENST00000550200, 
ENST00000430690, ENST00000436558, 
ENST00000456690, ENST00000439907, 
ENST00000444974, ENST00000439865, 
ENST00000413638, ENST00000423640, 
ENST00000444192, ENST00000551797, 
ENST00000552514, ENST00000440361, 
ENST00000443974, ENST00000416886, 
ENST00000436205, ENST00000450610, 
ENST00000433697, ENST00000414434, 
ENST00000421605, ENST00000444331, 
ENST00000551957, ENST00000550492, 
ENST00000423916, ENST00000436495, 
ENST00000426843, ENST00000421039, 
ENST00000414536, ENST00000400038, 
ENST00000383384, ENST00000383385, 
ENST00000383383, ENST00000547624, 
ENST00000550685, ENST00000400037, 
ENST00000400035, ENST00000400034, 
ENST00000400039, 
ENST00000558401, 
ENST00000559916, ENST00000544417, 
ENST00000559220, 
Fusion gene scores* DoF score9 X 7 X 3=18914 X 19 X 3=798
# samples 1023
** MAII scorelog2(10/189*10)=-0.918386234446348
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(23/798*10)=-1.79475488527797
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C6orf48 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneB2M

GO:0002726

positive regulation of T cell cytokine production

24643698

TgeneB2M

GO:1900121

negative regulation of receptor binding

9465039


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB959220C6orf48chr6

3096425

+B2Mchr15

45010033

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000375640ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375640ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375640ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375640ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375641ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375641ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375641ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375641ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375638ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375638ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375638ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375638ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375635ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375635ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375635ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375635ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375639ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375639ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375639ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375639ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375642ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375642ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375642ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375642ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000395789ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000395789ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000395789ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000395789ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375633ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375633ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000375633ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000375633ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000395788ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000395788ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000395788ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000395788ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000424962ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000424962ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000424962ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000424962ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000456268ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000456268ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000456268ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000456268ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000435938ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000435938ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000435938ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000435938ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000433752ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000433752ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000433752ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000433752ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000458514ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000458514ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000458514ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000458514ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000549426ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000549426ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000549426ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000549426ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000550200ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000550200ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000550200ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000550200ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000430690ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000430690ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000430690ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000430690ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000436558ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000436558ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000436558ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000436558ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000456690ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000456690ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000456690ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000456690ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000439907ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000439907ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000439907ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000439907ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000444974ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000444974ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000444974ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000444974ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000439865ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000439865ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000439865ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000439865ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000413638ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000413638ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000413638ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000413638ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000423640ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000423640ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000423640ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000423640ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000444192ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000444192ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000444192ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000444192ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000551797ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000551797ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000551797ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000551797ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000552514ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000552514ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000552514ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000552514ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000440361ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000440361ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000440361ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000440361ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000443974ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000443974ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000443974ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000443974ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000416886ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000416886ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000416886ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000416886ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000436205ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000436205ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000436205ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000436205ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000450610ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000450610ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000450610ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000450610ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000433697ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000433697ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000433697ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000433697ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000414434ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000414434ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000414434ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000414434ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000421605ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000421605ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000421605ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000421605ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000444331ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000444331ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000444331ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000444331ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000551957ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000551957ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000551957ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000551957ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000550492ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000550492ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000550492ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000550492ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000423916ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000423916ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000423916ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000423916ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000436495ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000436495ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000436495ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000436495ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000426843ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000426843ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000426843ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000426843ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000421039ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000421039ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000421039ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000421039ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000414536ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000414536ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000414536ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000414536ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000400038ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000400038ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000400038ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000400038ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000383384ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000383384ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000383384ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000383384ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000383385ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000383385ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000383385ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000383385ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000383383ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000383383ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000383383ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000383383ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
5CDS-3UTRENST00000547624ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
5CDS-intronENST00000547624ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
5CDS-intronENST00000547624ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
5CDS-3UTRENST00000547624ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
5CDS-3UTRENST00000550685ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
5CDS-intronENST00000550685ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
5CDS-intronENST00000550685ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
5CDS-3UTRENST00000550685ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000400037ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000400037ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000400037ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000400037ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000400035ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000400035ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-intronENST00000400035ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
5UTR-3UTRENST00000400035ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000400034ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000400034ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000400034ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000400034ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000400039ENST00000558401C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000400039ENST00000559916C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-intronENST00000400039ENST00000544417C6orf48chr6

3096425

+B2Mchr15

45010033

+
intron-3UTRENST00000400039ENST00000559220C6orf48chr6

3096425

+B2Mchr15

45010033

+

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FusionProtFeatures for C6orf48_B2M


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C6orf48

Q9UBA6

B2M

P61769

Component of the class I major histocompatibilitycomplex (MHC). Involved in the presentation of peptide antigens tothe immune system. Exogenously applied M.tuberculosis EsxA orEsxA-EsxB (or EsxA expressed in host) binds B2M and decreases itsexport to the cell surface (total protein levels do not change),probably leading to defects in class I antigen presentation(PubMed:25356553). {ECO:0000269|PubMed:25356553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C6orf48_B2M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C6orf48_B2M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for C6orf48_B2M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneB2MP61769DB00254DoxycyclineBeta-2-microglobulinsmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for C6orf48_B2M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneB2MC0022658Kidney Diseases3CTD_human;HPO
TgeneB2MC2609414Acute kidney injury2CTD_human
TgeneB2MC0004364Autoimmune Diseases1CTD_human
TgeneB2MC0018799Heart Diseases1CTD_human
TgeneB2MC0020455Hypergammaglobulinemia1CTD_human
TgeneB2MC0033578Prostatic Neoplasms1CTD_human
TgeneB2MC0036341Schizophrenia1PSYGENET
TgeneB2MC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneB2MC0079774Peripheral T-Cell Lymphoma1CTD_human
TgeneB2MC0268389Amyloidosis, familial visceral1UNIPROT
TgeneB2MC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneB2MC1855796Hypoproteinemia, Hypercatabolic1CTD_human;UNIPROT