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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4993

FusionGeneSummary for C3orf55_KCNAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: C3orf55_KCNAB1
Fusion gene ID: 4993
HgeneTgene
Gene symbol

C3orf55

KCNAB1

Gene ID

152078

7881

Gene namePQ loop repeat containing 2 likepotassium voltage-gated channel subfamily A member regulatory beta subunit 1
SynonymsC3orf55AKR6A3|KCNA1B|KV-BETA-1|Kvb1.3|hKvBeta3|hKvb3
Cytomap

3q25.32

3q25.31

Type of geneprotein-codingprotein-coding
Descriptionputative uncharacterized protein PQLC2LPQ-loop repeat-containing protein 2-likevoltage-gated potassium channel subunit beta-1K(+) channel subunit beta-1K+ channel Beta1a chainpotassium channel beta 3 chainpotassium channel beta3 subunitpotassium channel shaker chain beta 1apotassium channel, voltage gated subfamily A regulator
Modification date2018032920180522
UniProtAcc

Q14722

Ensembl transtripts involved in fusion geneENST00000312275, ENST00000498159, 
ENST00000468043, ENST00000459838, 
ENST00000461040, ENST00000449199, 
ENST00000426338, 
ENST00000490337, 
ENST00000389636, ENST00000471742, 
ENST00000302490, ENST00000389634, 
ENST00000497291, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 6=180
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C3orf55 [Title/Abstract] AND KCNAB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKCNAB1

GO:1901379

regulation of potassium ion transmembrane transport

7890032


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-CG-4449-01AC3orf55chr3

157271129

+KCNAB1chr3

155836000

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000312275ENST00000490337C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000312275ENST00000389636C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000312275ENST00000471742C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000312275ENST00000302490C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000312275ENST00000389634C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000312275ENST00000497291C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
intron-intronENST00000498159ENST00000490337C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
intron-intronENST00000498159ENST00000389636C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
intron-intronENST00000498159ENST00000471742C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
intron-intronENST00000498159ENST00000302490C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
intron-intronENST00000498159ENST00000389634C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
intron-intronENST00000498159ENST00000497291C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000468043ENST00000490337C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000468043ENST00000389636C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000468043ENST00000471742C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000468043ENST00000302490C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000468043ENST00000389634C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000468043ENST00000497291C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000459838ENST00000490337C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000459838ENST00000389636C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000459838ENST00000471742C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000459838ENST00000302490C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000459838ENST00000389634C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000459838ENST00000497291C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000461040ENST00000490337C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000461040ENST00000389636C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000461040ENST00000471742C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000461040ENST00000302490C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000461040ENST00000389634C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000461040ENST00000497291C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000449199ENST00000490337C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000449199ENST00000389636C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000449199ENST00000471742C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000449199ENST00000302490C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000449199ENST00000389634C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000449199ENST00000497291C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000426338ENST00000490337C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000426338ENST00000389636C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000426338ENST00000471742C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000426338ENST00000302490C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000426338ENST00000389634C3orf55chr3

157271129

+KCNAB1chr3

155836000

+
5CDS-intronENST00000426338ENST00000497291C3orf55chr3

157271129

+KCNAB1chr3

155836000

+

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FusionProtFeatures for C3orf55_KCNAB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C3orf55

KCNAB1

Q14722

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C3orf55_KCNAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C3orf55_KCNAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C3orf55KCNAB1KCNA2, NEDD4L, NEDD4, ELAVL1, ARRB2, KCNA5, GNB2L1, APP, SRPK1, KCNAB2, ATIC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C3orf55_KCNAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C3orf55_KCNAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource