FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4992

FusionGeneSummary for C3orf55_CHRD

check button Fusion gene summary
Fusion gene informationFusion gene name: C3orf55_CHRD
Fusion gene ID: 4992
HgeneTgene
Gene symbol

C3orf55

CHRD

Gene ID

152078

8646

Gene namePQ loop repeat containing 2 likechordin
SynonymsC3orf55-
Cytomap

3q25.32

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionputative uncharacterized protein PQLC2LPQ-loop repeat-containing protein 2-likechordin
Modification date2018032920180519
UniProtAcc

Q9H2X0

Ensembl transtripts involved in fusion geneENST00000312275, ENST00000498159, 
ENST00000468043, ENST00000459838, 
ENST00000461040, ENST00000449199, 
ENST00000426338, 
ENST00000310236, 
ENST00000204604, ENST00000450923, 
ENST00000348986, ENST00000482805, 
ENST00000545352, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/4*10)=1.32192809488736
Context

PubMed: C3orf55 [Title/Abstract] AND CHRD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHRD

GO:0030336

negative regulation of cell migration

16449796

TgeneCHRD

GO:0045785

positive regulation of cell adhesion

16449796


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-39-5019-01AC3orf55chr3

157261298

+CHRDchr3

184106375

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000312275ENST00000310236C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000312275ENST00000204604C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000312275ENST00000450923C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000312275ENST00000348986C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000312275ENST00000482805C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000312275ENST00000545352C3orf55chr3

157261298

+CHRDchr3

184106375

+
3UTR-intronENST00000498159ENST00000310236C3orf55chr3

157261298

+CHRDchr3

184106375

+
3UTR-intronENST00000498159ENST00000204604C3orf55chr3

157261298

+CHRDchr3

184106375

+
3UTR-intronENST00000498159ENST00000450923C3orf55chr3

157261298

+CHRDchr3

184106375

+
3UTR-intronENST00000498159ENST00000348986C3orf55chr3

157261298

+CHRDchr3

184106375

+
3UTR-intronENST00000498159ENST00000482805C3orf55chr3

157261298

+CHRDchr3

184106375

+
3UTR-intronENST00000498159ENST00000545352C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000468043ENST00000310236C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000468043ENST00000204604C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000468043ENST00000450923C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000468043ENST00000348986C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000468043ENST00000482805C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000468043ENST00000545352C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000459838ENST00000310236C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000459838ENST00000204604C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000459838ENST00000450923C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000459838ENST00000348986C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000459838ENST00000482805C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000459838ENST00000545352C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000461040ENST00000310236C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000461040ENST00000204604C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000461040ENST00000450923C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000461040ENST00000348986C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000461040ENST00000482805C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000461040ENST00000545352C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000449199ENST00000310236C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000449199ENST00000204604C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000449199ENST00000450923C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000449199ENST00000348986C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000449199ENST00000482805C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000449199ENST00000545352C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000426338ENST00000310236C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000426338ENST00000204604C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000426338ENST00000450923C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000426338ENST00000348986C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000426338ENST00000482805C3orf55chr3

157261298

+CHRDchr3

184106375

+
5UTR-intronENST00000426338ENST00000545352C3orf55chr3

157261298

+CHRDchr3

184106375

+

Top

FusionProtFeatures for C3orf55_CHRD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C3orf55

CHRD

Q9H2X0

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for C3orf55_CHRD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for C3orf55_CHRD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C3orf55CHRDTWSG1, BMP1, ATN1, SMAD3, F2R, HRG, NR0B2, CD36, HOXA1, KRTAP5-9, MEOX2, OTX1, PLSCR1, SPRY2, KRTAP9-2, KRTAP4-2, CATSPER1, KRTAP10-7, KRTAP10-9, KRTAP10-1, KRTAP10-5, KRTAP10-8, KRTAP10-3, NOTCH2NL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for C3orf55_CHRD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for C3orf55_CHRD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource