FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 498

FusionGeneSummary for ACSS1_ZNF131

check button Fusion gene summary
Fusion gene informationFusion gene name: ACSS1_ZNF131
Fusion gene ID: 498
HgeneTgene
Gene symbol

ACSS1

ZNF131

Gene ID

84532

7690

Gene nameacyl-CoA synthetase short chain family member 1zinc finger protein 131
SynonymsACAS2L|ACECS1|AceCS2LZBTB35|pHZ-10
Cytomap

20p11.21

5p12

Type of geneprotein-codingprotein-coding
Descriptionacetyl-coenzyme A synthetase 2-like, mitochondrialacetate--CoA ligase 2zinc finger protein 131zinc finger and BTB domain containing 35zinc finger protein 131 (clone pHZ-10)
Modification date2018051920180523
UniProtAcc

Q9NUB1

P52739

Ensembl transtripts involved in fusion geneENST00000323482, ENST00000432802, 
ENST00000376726, ENST00000484396, 
ENST00000537502, ENST00000542618, 
ENST00000509156, ENST00000306938, 
ENST00000399534, ENST00000505606, 
ENST00000509634, ENST00000509931, 
ENST00000499046, 
Fusion gene scores* DoF score6 X 5 X 5=1502 X 2 X 2=8
# samples 62
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ACSS1 [Title/Abstract] AND ZNF131 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACSS1

GO:0006085

acetyl-CoA biosynthetic process

16788062


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF790853ACSS1chr20

24987732

-ZNF131chr5

43175422

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000323482ENST00000509156ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000323482ENST00000306938ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000323482ENST00000399534ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000323482ENST00000505606ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000323482ENST00000509634ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000323482ENST00000509931ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000323482ENST00000499046ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000432802ENST00000509156ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000432802ENST00000306938ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000432802ENST00000399534ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000432802ENST00000505606ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000432802ENST00000509634ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000432802ENST00000509931ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000432802ENST00000499046ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000376726ENST00000509156ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000376726ENST00000306938ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000376726ENST00000399534ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000376726ENST00000505606ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000376726ENST00000509634ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000376726ENST00000509931ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000376726ENST00000499046ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000484396ENST00000509156ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000484396ENST00000306938ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000484396ENST00000399534ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000484396ENST00000505606ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000484396ENST00000509634ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000484396ENST00000509931ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000484396ENST00000499046ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000537502ENST00000509156ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000537502ENST00000306938ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000537502ENST00000399534ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000537502ENST00000505606ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000537502ENST00000509634ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000537502ENST00000509931ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000537502ENST00000499046ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000542618ENST00000509156ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000542618ENST00000306938ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000542618ENST00000399534ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000542618ENST00000505606ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-3UTRENST00000542618ENST00000509634ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000542618ENST00000509931ACSS1chr20

24987732

-ZNF131chr5

43175422

+
intron-intronENST00000542618ENST00000499046ACSS1chr20

24987732

-ZNF131chr5

43175422

+

Top

FusionProtFeatures for ACSS1_ZNF131


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACSS1

Q9NUB1

ZNF131

P52739

Plays a role during development and organogenesis aswell as in the function of the adult central nervous system (Bysimilarity). May be involved in transcriptional regulation as arepressor of ESR1/ER-alpha signaling. {ECO:0000250,ECO:0000269|PubMed:18847501, ECO:0000269|PubMed:22467880}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ACSS1_ZNF131


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ACSS1_ZNF131


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ACSS1_ZNF131


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ACSS1_ZNF131


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource