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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 495

FusionGeneSummary for ACSS1_PHACTR3

check button Fusion gene summary
Fusion gene informationFusion gene name: ACSS1_PHACTR3
Fusion gene ID: 495
HgeneTgene
Gene symbol

ACSS1

PHACTR3

Gene ID

84532

116154

Gene nameacyl-CoA synthetase short chain family member 1phosphatase and actin regulator 3
SynonymsACAS2L|ACECS1|AceCS2LC20orf101|H17739|PPP1R123|SCAPIN1|SCAPININ
Cytomap

20p11.21

20q13.32-q13.33

Type of geneprotein-codingprotein-coding
Descriptionacetyl-coenzyme A synthetase 2-like, mitochondrialacetate--CoA ligase 2phosphatase and actin regulator 3protein phosphatase 1, regulatory subunit 123scaffold-associated PP1-inhibiting protein
Modification date2018051920180519
UniProtAcc

Q9NUB1

Q96KR7

Ensembl transtripts involved in fusion geneENST00000323482, ENST00000432802, 
ENST00000376726, ENST00000484396, 
ENST00000537502, ENST00000542618, 
ENST00000359926, ENST00000371015, 
ENST00000395639, ENST00000541461, 
ENST00000355648, ENST00000395636, 
ENST00000361300, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 2 X 2=12
# samples 63
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ACSS1 [Title/Abstract] AND PHACTR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACSS1

GO:0006085

acetyl-CoA biosynthetic process

16788062


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1XJ-01AACSS1chr20

25038405

-PHACTR3chr20

58318162

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000323482ENST00000359926ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
Frame-shiftENST00000323482ENST00000371015ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000323482ENST00000395639ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000323482ENST00000541461ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000323482ENST00000355648ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000323482ENST00000395636ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000323482ENST00000361300ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
Frame-shiftENST00000432802ENST00000359926ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
Frame-shiftENST00000432802ENST00000371015ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000432802ENST00000395639ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000432802ENST00000541461ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000432802ENST00000355648ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000432802ENST00000395636ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000432802ENST00000361300ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
Frame-shiftENST00000376726ENST00000359926ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
Frame-shiftENST00000376726ENST00000371015ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000376726ENST00000395639ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000376726ENST00000541461ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000376726ENST00000355648ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000376726ENST00000395636ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
5CDS-5UTRENST00000376726ENST00000361300ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-3CDSENST00000484396ENST00000359926ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-3CDSENST00000484396ENST00000371015ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000484396ENST00000395639ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000484396ENST00000541461ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000484396ENST00000355648ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000484396ENST00000395636ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000484396ENST00000361300ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-3CDSENST00000537502ENST00000359926ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-3CDSENST00000537502ENST00000371015ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000537502ENST00000395639ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000537502ENST00000541461ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000537502ENST00000355648ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000537502ENST00000395636ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000537502ENST00000361300ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-3CDSENST00000542618ENST00000359926ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-3CDSENST00000542618ENST00000371015ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000542618ENST00000395639ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000542618ENST00000541461ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000542618ENST00000355648ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000542618ENST00000395636ACSS1chr20

25038405

-PHACTR3chr20

58318162

+
intron-5UTRENST00000542618ENST00000361300ACSS1chr20

25038405

-PHACTR3chr20

58318162

+

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FusionProtFeatures for ACSS1_PHACTR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACSS1

Q9NUB1

PHACTR3

Q96KR7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACSS1_PHACTR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACSS1_PHACTR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACSS1VAC14, PPA2, ECI2, HSPD1, TMEM70, NDUFS7PHACTR3PPP1CA, EEF1G, MAPK6, TAB1, MCM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACSS1_PHACTR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACSS1_PHACTR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource