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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4906

FusionGeneSummary for C21orf33_TAZ

check button Fusion gene summary
Fusion gene informationFusion gene name: C21orf33_TAZ
Fusion gene ID: 4906
HgeneTgene
Gene symbol

C21orf33

TAZ

Gene ID

25937

Gene nameWW domain containing transcription regulator 1
SynonymsTAZ
Cytomap

3q25.1

Type of geneprotein-coding
DescriptionWW domain-containing transcription regulator protein 1transcriptional co-activator with PDZ-binding motif
Modification date20180522
UniProtAcc

Q16635

Ensembl transtripts involved in fusion geneENST00000291577, ENST00000427803, 
ENST00000493883, ENST00000348499, 
ENST00000369790, ENST00000350743, 
ENST00000299328, ENST00000351413, 
ENST00000369776, ENST00000475699, 
ENST00000498029, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: C21orf33 [Title/Abstract] AND TAZ [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAZ

GO:0008284

positive regulation of cell proliferation

18227151

TgeneTAZ

GO:0010718

positive regulation of epithelial to mesenchymal transition

18227151

TgeneTAZ

GO:0017145

stem cell division

18568018

TgeneTAZ

GO:0035329

hippo signaling

18227151|20412773

TgeneTAZ

GO:0060390

regulation of SMAD protein signal transduction

18568018


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW375494C21orf33chr21

45565491

-TAZchrX

153649922

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000291577ENST00000369790C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-3UTRENST00000291577ENST00000350743C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-3UTRENST00000291577ENST00000299328C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-3UTRENST00000291577ENST00000351413C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-3UTRENST00000291577ENST00000369776C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-intronENST00000291577ENST00000475699C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-intronENST00000291577ENST00000498029C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000427803ENST00000369790C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000427803ENST00000350743C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000427803ENST00000299328C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000427803ENST00000351413C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000427803ENST00000369776C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-intronENST00000427803ENST00000475699C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-intronENST00000427803ENST00000498029C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000493883ENST00000369790C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000493883ENST00000350743C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000493883ENST00000299328C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000493883ENST00000351413C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-3UTRENST00000493883ENST00000369776C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-intronENST00000493883ENST00000475699C21orf33chr21

45565491

-TAZchrX

153649922

+
intron-intronENST00000493883ENST00000498029C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-3UTRENST00000348499ENST00000369790C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-3UTRENST00000348499ENST00000350743C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-3UTRENST00000348499ENST00000299328C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-3UTRENST00000348499ENST00000351413C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-3UTRENST00000348499ENST00000369776C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-intronENST00000348499ENST00000475699C21orf33chr21

45565491

-TAZchrX

153649922

+
3UTR-intronENST00000348499ENST00000498029C21orf33chr21

45565491

-TAZchrX

153649922

+

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FusionProtFeatures for C21orf33_TAZ


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C21orf33

TAZ

Q16635

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C21orf33_TAZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C21orf33_TAZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C21orf33_TAZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C21orf33_TAZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTAZC05740833-Methylglutaconic aciduria type 26CTD_human;ORPHANET;UNIPROT