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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4881

FusionGeneSummary for C1orf61_ADD3

check button Fusion gene summary
Fusion gene informationFusion gene name: C1orf61_ADD3
Fusion gene ID: 4881
HgeneTgene
Gene symbol

C1orf61

ADD3

Gene ID

10485

120

Gene namechromosome 1 open reading frame 61adducin 3
SynonymsCROC4ADDL|CPSQ3
Cytomap

1q22

10q25.1-q25.2

Type of geneprotein-codingprotein-coding
Descriptionprotein CROC-4contingent replication of cDNA 4transcriptional activator of the c-fos promotergamma-adducinadducin 3 (gamma)adducin-like protein 70
Modification date2018032920180523
UniProtAcc

Q13536

Q9UEY8

Ensembl transtripts involved in fusion geneENST00000488498, ENST00000368243, 
ENST00000360162, ENST00000356080, 
ENST00000277900, ENST00000497125, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 5 X 2=50
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/50*10)=0
Context

PubMed: C1orf61 [Title/Abstract] AND ADD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC1orf61

GO:0045944

positive regulation of transcription by RNA polymerase II

10995546


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF924787C1orf61chr1

156381340

+ADD3chr10

111879314

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000488498ENST00000360162C1orf61chr1

156381340

+ADD3chr10

111879314

-
intron-3CDSENST00000488498ENST00000356080C1orf61chr1

156381340

+ADD3chr10

111879314

-
intron-3CDSENST00000488498ENST00000277900C1orf61chr1

156381340

+ADD3chr10

111879314

-
intron-intronENST00000488498ENST00000497125C1orf61chr1

156381340

+ADD3chr10

111879314

-
intron-3CDSENST00000368243ENST00000360162C1orf61chr1

156381340

+ADD3chr10

111879314

-
intron-3CDSENST00000368243ENST00000356080C1orf61chr1

156381340

+ADD3chr10

111879314

-
intron-3CDSENST00000368243ENST00000277900C1orf61chr1

156381340

+ADD3chr10

111879314

-
intron-intronENST00000368243ENST00000497125C1orf61chr1

156381340

+ADD3chr10

111879314

-

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FusionProtFeatures for C1orf61_ADD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C1orf61

Q13536

ADD3

Q9UEY8

May play a role in FOS signaling pathways involved indevelopment and remodeling of neurons. Promotes transcription ofthe FOS promoter. {ECO:0000269|PubMed:10995546}. Membrane-cytoskeleton-associated protein that promotesthe assembly of the spectrin-actin network. Plays a role in actinfilament capping (PubMed:23836506). Binds to calmodulin.{ECO:0000269|PubMed:23836506}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C1orf61_ADD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C1orf61_ADD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C1orf61_ADD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C1orf61_ADD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADD3C0007786Brain Ischemia1CTD_human
TgeneADD3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneADD3C0235032Neurotoxicity Syndromes1CTD_human