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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4872

FusionGeneSummary for C1orf21_INTS7

check button Fusion gene summary
Fusion gene informationFusion gene name: C1orf21_INTS7
Fusion gene ID: 4872
HgeneTgene
Gene symbol

C1orf21

INTS7

Gene ID

81563

25896

Gene namechromosome 1 open reading frame 21integrator complex subunit 7
SynonymsPIG13C1orf73|INT7
Cytomap

1q25.3

1q32.3

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C1orf21cell proliferation-inducing gene 13 proteinproliferation-inducing protein 13integrator complex subunit 7
Modification date2018051920180523
UniProtAcc

Q9H246

Q9NVH2

Ensembl transtripts involved in fusion geneENST00000235307, ENST00000367514, 
ENST00000469606, ENST00000366994, 
ENST00000366993, ENST00000366992, 
ENST00000440600, 
Fusion gene scores* DoF score6 X 5 X 4=1205 X 5 X 5=125
# samples 66
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C1orf21 [Title/Abstract] AND INTS7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINTS7

GO:0016180

snRNA processing

16239144

TgeneINTS7

GO:0071479

cellular response to ionizing radiation

21659603


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1L0-01AC1orf21chr1

184567595

+INTS7chr1

212126043

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000235307ENST00000469606C1orf21chr1

184567595

+INTS7chr1

212126043

-
5CDS-5UTRENST00000235307ENST00000366994C1orf21chr1

184567595

+INTS7chr1

212126043

-
5CDS-5UTRENST00000235307ENST00000366993C1orf21chr1

184567595

+INTS7chr1

212126043

-
5CDS-5UTRENST00000235307ENST00000366992C1orf21chr1

184567595

+INTS7chr1

212126043

-
5CDS-5UTRENST00000235307ENST00000440600C1orf21chr1

184567595

+INTS7chr1

212126043

-
3UTR-5UTRENST00000367514ENST00000469606C1orf21chr1

184567595

+INTS7chr1

212126043

-
3UTR-5UTRENST00000367514ENST00000366994C1orf21chr1

184567595

+INTS7chr1

212126043

-
3UTR-5UTRENST00000367514ENST00000366993C1orf21chr1

184567595

+INTS7chr1

212126043

-
3UTR-5UTRENST00000367514ENST00000366992C1orf21chr1

184567595

+INTS7chr1

212126043

-
3UTR-5UTRENST00000367514ENST00000440600C1orf21chr1

184567595

+INTS7chr1

212126043

-

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FusionProtFeatures for C1orf21_INTS7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C1orf21

Q9H246

INTS7

Q9NVH2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C1orf21_INTS7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C1orf21_INTS7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C1orf21DRAM1, SHMT2, MOV10, NXF1, TMEM185AINTS7RPAP2, INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, CTDP1, INTS2, INTS8, PAXIP1, SOX2, DCP2, SSBP1, HLA-DPA1, SPACA1, NRG1, SLAMF1, DLK1, TMEFF1, PRKCSH, VSIG4, FNDC4, FAF2, C7orf26, CPSF3L, ASUN, FGD1, HNRNPD, PML, RALA, BUB3, VPS26A, CKAP5, SYNCRIP, KIF1C, GOLT1B, ANLN, ACTR5, SCN3B, VSIG1, CD79B, PDCD1, TOR1AIP2, CLEC14A, PMEL, NTRK3, MGRN1, TNFRSF17, IL13RA2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C1orf21_INTS7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C1orf21_INTS7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource