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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4864

FusionGeneSummary for C1orf186_SRGAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: C1orf186_SRGAP2
Fusion gene ID: 4864
HgeneTgene
Gene symbol

C1orf186

SRGAP2

Gene ID

23380

Gene nameSLIT-ROBO Rho GTPase activating protein 2
SynonymsARHGAP34|FNBP2|SRGAP2A|SRGAP3
Cytomap

1q32.1

Type of geneprotein-coding
DescriptionSLIT-ROBO Rho GTPase-activating protein 2SLIT-ROBO GAP2formin-binding protein 2rho GTPase-activating protein 34
Modification date20180523
UniProtAcc

Ensembl transtripts involved in fusion geneENST00000331555, ENST00000469540, 
ENST00000414007, ENST00000419187, 
ENST00000471256, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 9 X 6=486
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/486*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C1orf186 [Title/Abstract] AND SRGAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRGAP2

GO:0043547

positive regulation of GTPase activity

21148482

TgeneSRGAP2

GO:0046847

filopodium assembly

22559944

TgeneSRGAP2

GO:0051014

actin filament severing

21148482

TgeneSRGAP2

GO:0060996

dendritic spine development

22559944

TgeneSRGAP2

GO:2001223

negative regulation of neuron migration

22559944


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-2267-01AC1orf186chr1

206280922

+SRGAP2chr1

206603512

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000331555ENST00000414007C1orf186chr1

206280922

+SRGAP2chr1

206603512

+
intron-5UTRENST00000331555ENST00000419187C1orf186chr1

206280922

+SRGAP2chr1

206603512

+
intron-intronENST00000331555ENST00000471256C1orf186chr1

206280922

+SRGAP2chr1

206603512

+
5UTR-3CDSENST00000469540ENST00000414007C1orf186chr1

206280922

+SRGAP2chr1

206603512

+
5UTR-5UTRENST00000469540ENST00000419187C1orf186chr1

206280922

+SRGAP2chr1

206603512

+
5UTR-intronENST00000469540ENST00000471256C1orf186chr1

206280922

+SRGAP2chr1

206603512

+

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FusionProtFeatures for C1orf186_SRGAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C1orf186

SRGAP2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C1orf186_SRGAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C1orf186_SRGAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C1orf186SNX17, WDR47, JPH1, TMTC4, SBF1, DYNLL1, PLXDC2, SENP5, DIP2A, PLD1, PKN1, ZBTB9, FIGNL1, NOS1APSRGAP2ATAD3A, DIAPH1, ITSN2, MYO1G, YLPM1, SLC25A12, WAS, WIPF1, YWHAG, DISC1, EXOC1, HERC2, FASLG, YWHAE, YWHAB, PPP2R1A, LUZP4, SRGAP3, NTRK1, PCM1, CEP19, CDH1, TRIML2, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, EIF4E2, SIPA1L1, LIMA1, RTKN, MAGI1, MAST3, TESK2, DENND4C, DCLK1, CGN, PPM1H, ZNF638, SRSF12, SYDE1, MAPKAP1, AGAP1, CDC25B, CDK16, FAM110B, HDAC4, USP21, FAM53C, ANKRD34A, NF1, CBY1, LPIN3, FAM110A, NADK, TIAM1, KIAA1804, CDC25C, PHLDB2, RASAL2, CAMSAP2, GIGYF2, PLEKHA7, MELK, TBC1D25, SH3RF3, GAB2, KIF1C, NAV1, DENND4A, RPTOR, TANC2, PTPN13, DEPDC1B, PTPN14, RALGPS2, STARD13, OSBPL6, MLLT4, HDAC7, PLEKHA5, LARP1, EDC3, SH3BP4, RAB11FIP2, CHEK1, KIF1B, INPP5E, RAB3IP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C1orf186_SRGAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C1orf186_SRGAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource