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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4841

FusionGeneSummary for C1orf112_OR5H14

check button Fusion gene summary
Fusion gene informationFusion gene name: C1orf112_OR5H14
Fusion gene ID: 4841
HgeneTgene
Gene symbol

C1orf112

OR5H14

Gene ID

55732

403273

Gene namechromosome 1 open reading frame 112olfactory receptor family 5 subfamily H member 14
Synonyms--
Cytomap

1q24.2

3q11.2

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C1orf112olfactory receptor 5H14seven transmembrane helix receptor
Modification date2018051920180523
UniProtAcc

Q9NSG2

A6NHG9

Ensembl transtripts involved in fusion geneENST00000498289, ENST00000413811, 
ENST00000359326, ENST00000456684, 
ENST00000286031, 
ENST00000437310, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: C1orf112 [Title/Abstract] AND OR5H14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDMESOTCGA-MQ-A4LM-01AC1orf112chr1

169652766

+OR5H14chr3

97868212

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000498289ENST00000437310C1orf112chr1

169652766

+OR5H14chr3

97868212

+
intron-5UTRENST00000413811ENST00000437310C1orf112chr1

169652766

+OR5H14chr3

97868212

+
intron-5UTRENST00000359326ENST00000437310C1orf112chr1

169652766

+OR5H14chr3

97868212

+
intron-5UTRENST00000456684ENST00000437310C1orf112chr1

169652766

+OR5H14chr3

97868212

+
intron-5UTRENST00000286031ENST00000437310C1orf112chr1

169652766

+OR5H14chr3

97868212

+

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FusionProtFeatures for C1orf112_OR5H14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C1orf112

Q9NSG2

OR5H14

A6NHG9

Odorant receptor. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C1orf112_OR5H14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C1orf112_OR5H14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C1orf112APP, SPINT2, PTH1R, AGTR1, HLA-B, P2RY8, PTGER3, ALDH3A2, TSSC4, DENND4C, FIGNL1, SPATA5L1, C5orf30, TMEM263, CD83, EDNRB, OPRM1, C5AR2, FCGRT, VIPR2, CHRM3, TNFRSF1AOR5H14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C1orf112_OR5H14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C1orf112_OR5H14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource