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Fusion gene ID: 4822 |
FusionGeneSummary for C1QTNF3_CLPTM1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C1QTNF3_CLPTM1L | Fusion gene ID: 4822 | Hgene | Tgene | Gene symbol | C1QTNF3 | CLPTM1L | Gene ID | 114899 | 81037 |
| Gene name | C1q and TNF related 3 | CLPTM1 like | |
| Synonyms | C1ATNF3|CORCS|CORS|CORS-26|CORS26|CTRP3 | CRR9 | |
| Cytomap | 5p13.2 | 5p15.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | complement C1q tumor necrosis factor-related protein 3C1q and tumor necrosis factor related protein 3cartonectincollagenous repeat-containing sequence 26 kDa proteincollagenous repeat-containing sequence of 26-kDasecretory protein CORS26 | cleft lip and palate transmembrane protein 1-like proteinCLPTM1-like proteincisplatin resistance related protein CRR9pcisplatin resistance-related protein 9 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9BXJ4 | Q96KA5 | |
| Ensembl transtripts involved in fusion gene | ENST00000382065, ENST00000231338, ENST00000513065, | ENST00000320895, ENST00000507807, ENST00000320927, ENST00000506641, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 12 X 8 X 6=576 |
| # samples | 1 | 12 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/576*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C1QTNF3 [Title/Abstract] AND CLPTM1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | C1QTNF3 | GO:0035356 | cellular triglyceride homeostasis | 20739398 |
| Hgene | C1QTNF3 | GO:0045721 | negative regulation of gluconeogenesis | 20952387 |
| Hgene | C1QTNF3 | GO:0050715 | positive regulation of cytokine secretion | 18421280 |
| Hgene | C1QTNF3 | GO:0050728 | negative regulation of inflammatory response | 16213490 |
| Hgene | C1QTNF3 | GO:0070165 | positive regulation of adiponectin secretion | 18421280 |
| Hgene | C1QTNF3 | GO:0070206 | protein trimerization | 16213490 |
| Hgene | C1QTNF3 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production | 20739398 |
| Hgene | C1QTNF3 | GO:1900165 | negative regulation of interleukin-6 secretion | 16213490 |
| Hgene | C1QTNF3 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling | 16213490 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-2Z-A9JJ-01A | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000382065 | ENST00000320895 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| Frame-shift | ENST00000382065 | ENST00000507807 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| In-frame | ENST00000382065 | ENST00000320927 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| 5CDS-5UTR | ENST00000382065 | ENST00000506641 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| Frame-shift | ENST00000231338 | ENST00000320895 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| Frame-shift | ENST00000231338 | ENST00000507807 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| In-frame | ENST00000231338 | ENST00000320927 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| 5CDS-5UTR | ENST00000231338 | ENST00000506641 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| 5UTR-3CDS | ENST00000513065 | ENST00000320895 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| 5UTR-3CDS | ENST00000513065 | ENST00000507807 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| 5UTR-3CDS | ENST00000513065 | ENST00000320927 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
| 5UTR-5UTR | ENST00000513065 | ENST00000506641 | C1QTNF3 | chr5 | 34028859 | - | CLPTM1L | chr5 | 1318568 | - |
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FusionProtFeatures for C1QTNF3_CLPTM1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C1QTNF3 | CLPTM1L |
| Enhances cisplatin-mediated apoptosis, whenoverexpressed. {ECO:0000269|PubMed:11162647}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C1QTNF3_CLPTM1L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_C1QTNF3_ENST00000382065_chr5_34028859_-_CLPTM1L_ENST00000320927_chr5_1318568_-_261aa MLWRQLIYWQLLALFFLPFCLCQDEYMEVSGRTNKVVARIVQSHQQTGRSGSRREKVRERSHPKTGTVDNNTSTDLKSLRPDELPHPEVD DLAQITTFWGQSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEK >In-frame_C1QTNF3_ENST00000231338_chr5_34028859_-_CLPTM1L_ENST00000320927_chr5_1318568_-_188aa MLWRQLIYWQLLALFFLPFCLCQDEYMESPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKG DLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGFILWINAEXTSLGSPTRRR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_C1QTNF3_ENST00000382065_chr5_34028859_-_CLPTM1L_ENST00000320927_chr5_1318568_-_785nt ATGCTTTGGAGGCAGCTCATCTATTGGCAACTGCTGGCTTTGTTTTTCCTCCCTTTTTGCCTGTGTCAAGATGAATACATGGAGGTGAGC GGAAGAACTAATAAAGTGGTGGCAAGAATAGTGCAAAGCCACCAGCAGACTGGCCGTAGCGGCTCCAGGAGGGAGAAAGTGAGAGAGCGG AGCCATCCTAAAACTGGGACTGTGGATAATAACACTTCTACAGACCTAAAATCCCTGAGACCAGATGAGCTACCGCACCCCGAGGTAGAT GACCTAGCCCAGATCACCACATTCTGGGGCCAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTAC AGCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACT GGTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAG GGCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTC AGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGCTTTATCCTGTGGATAAAC >In-frame_C1QTNF3_ENST00000231338_chr5_34028859_-_CLPTM1L_ENST00000320927_chr5_1318568_-_566nt ATGCTTTGGAGGCAGCTCATCTATTGGCAACTGCTGGCTTTGTTTTTCCTCCCTTTTTGCCTGTGTCAAGATGAATACATGGAGTCTCCA CAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGC CCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGT GACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTC ATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTC ATGACTGGTAGATTTGGGGCCCCAGTATCAGGCTTTATCCTGTGGATAAACGCAGAGTGAACGAGTTTGGGGAGTCCTACGAGGAGAAGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_C1QTNF3_ENST00000382065_chr5_34028859_-_CLPTM1L_ENST00000320927_chr5_1318568_-_1993nt TTTTGGCTTTTGGGAAGTCATGGGGAAAAGAAGTAAAGCTGAGGGTGGCGAAATACCTTTGCTAAACCCAGAGACACTGCACCTGAATCC TGCTCAGTGTTTTGTAGGCAACCAACTGCCTTCTGCCACTGGTATCCGGAAGGGGAAATGAGTTACCTTAAGTGGGCCAAAGTGGGGAAA TACTAACAGTACAGCTAGAAACCAAGAGCTGTCGTGAAAGCCCTGAATGGGTTCCCACTGCTATTTCAGACAAAACTGATGCAGTTAAGC CTGAATTTCCTGGCAAGCACAAGGGTAGATTTTTCCAAAAGGCTTTTTAGACTGCAAATACACAGCCTTTCCATGTCTAATCACAAAAGC AAACTGCTGGACACATGCTCTCTGTTCCCAGCTGGTTGTGTATGTTTTCTTCACACTTCAACAGAAACGTGCCAAGGTGTGACATTTATG AATTTCGCCAACTGGGAACTGTGCACACAAATCGTTCTTGCTTGTGGTGTGGGAAAATGATGAATGGGGGCTGTTCTGCCTGGGGAGGAG GGCTGCTGTCACTCTGGCATGCCTACAGCCTTATTTATTACACACCAAAGTATAAAACCACTCCGCCGCTGCAGCTCTCAGCTCCAGTCC TGGCATCTGCCCGAGGAGACCACGCTCCTGGAGCTCTGCTGTCTTCTCAGGGAGACTCTGAGGCTCTGTTGAGAATCATGCTTTGGAGGC AGCTCATCTATTGGCAACTGCTGGCTTTGTTTTTCCTCCCTTTTTGCCTGTGTCAAGATGAATACATGGAGGTGAGCGGAAGAACTAATA AAGTGGTGGCAAGAATAGTGCAAAGCCACCAGCAGACTGGCCGTAGCGGCTCCAGGAGGGAGAAAGTGAGAGAGCGGAGCCATCCTAAAA CTGGGACTGTGGATAATAACACTTCTACAGACCTAAAATCCCTGAGACCAGATGAGCTACCGCACCCCGAGGTAGATGACCTAGCCCAGA TCACCACATTCTGGGGCCAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCT ACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAG CCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGA TTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGA CCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGCTTTATCCTGTGGATAAACGCAGAGTGAACGA GTTTGGGGAGTCCTACGAGGAGAAGGCCACGCGGGCGCCCCACACGGACTGAAGGCCGCCCGGGCTGCCGCCAGCCAAGTGCAACTTGAA TTGTCAATGAGTATTTTTGGAAGCATTTGGAGGAATTCCTAGACATTGCGTTTTCTGTGTTGCCAAAATCCCTTCGGACATTTCTCAGAC ATCTCCCAAGTTCCCATCACGTCAGATTTGGAGCTGGTAGCGCTTACGATGCCCCCACGTGTGAACATCTGTCTTGGTCACAGAGCTGGG TGCTGCCGGTCACCTTGAGCTGTGGTGGCTCCCGGCACACGAGTGTCCGGGGTTCGGCCATGTCCTCACGCGGGCAGGGGTGGGAGCCCT CACAGGCAAGGGGGCTGTTGGATTTCCATTTCAGGTGGTTTTCTAAGTGCTCCTTATGTGAATTTCAAACACGTATGGAATTCATTCCGC ATGGACTCTGGGATCAAAGGCTCTTTCCTCTTTTGTTTGAGAGTTGGTTGTTTTAAAGCTTAATGTATGTTTCTATTTTAAAATAAATTT >In-frame_C1QTNF3_ENST00000231338_chr5_34028859_-_CLPTM1L_ENST00000320927_chr5_1318568_-_1155nt AGCTCCAGTCCTGGCATCTGCCCGAGGAGACCACGCTCCTGGAGCTCTGCTGTCTTCTCAGGGAGACTCTGAGGCTCTGTTGAGAATCAT GCTTTGGAGGCAGCTCATCTATTGGCAACTGCTGGCTTTGTTTTTCCTCCCTTTTTGCCTGTGTCAAGATGAATACATGGAGTCTCCACA AACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCC TCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGA CCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCAT GGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCAT GACTGGTAGATTTGGGGCCCCAGTATCAGGCTTTATCCTGTGGATAAACGCAGAGTGAACGAGTTTGGGGAGTCCTACGAGGAGAAGGCC ACGCGGGCGCCCCACACGGACTGAAGGCCGCCCGGGCTGCCGCCAGCCAAGTGCAACTTGAATTGTCAATGAGTATTTTTGGAAGCATTT GGAGGAATTCCTAGACATTGCGTTTTCTGTGTTGCCAAAATCCCTTCGGACATTTCTCAGACATCTCCCAAGTTCCCATCACGTCAGATT TGGAGCTGGTAGCGCTTACGATGCCCCCACGTGTGAACATCTGTCTTGGTCACAGAGCTGGGTGCTGCCGGTCACCTTGAGCTGTGGTGG CTCCCGGCACACGAGTGTCCGGGGTTCGGCCATGTCCTCACGCGGGCAGGGGTGGGAGCCCTCACAGGCAAGGGGGCTGTTGGATTTCCA TTTCAGGTGGTTTTCTAAGTGCTCCTTATGTGAATTTCAAACACGTATGGAATTCATTCCGCATGGACTCTGGGATCAAAGGCTCTTTCC |
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FusionGenePPI for C1QTNF3_CLPTM1L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| C1QTNF3 | COLGALT2, MAPK8IP2 | CLPTM1L | PIK3C3, TMEM173, UNC93B1, SPTAN1, MRPL47, UQCRQ, GK, EMC7, NTRK1, TCTN2, TCTN3, TUBG1, ZBTB33, NCSTN, NDE1, NCDN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C1QTNF3_CLPTM1L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C1QTNF3_CLPTM1L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | C1QTNF3 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | CLPTM1L | C0024121 | Lung Neoplasms | 3 | CTD_human |
| Tgene | CLPTM1L | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | CLPTM1L | C0007117 | Basal cell carcinoma | 1 | CTD_human |
| Tgene | CLPTM1L | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | CLPTM1L | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
| Tgene | CLPTM1L | C0023448 | Lymphoid leukemia | 1 | CTD_human |
| Tgene | CLPTM1L | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Tgene | CLPTM1L | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | CLPTM1L | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
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