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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4816

FusionGeneSummary for C1QC_C1QC

check button Fusion gene summary
Fusion gene informationFusion gene name: C1QC_C1QC
Fusion gene ID: 4816
HgeneTgene
Gene symbol

C1QC

C1QC

Gene ID

714

714

Gene namecomplement C1q C chaincomplement C1q C chain
SynonymsC1Q-C|C1QGC1Q-C|C1QG
Cytomap

1p36.12

1p36.12

Type of geneprotein-codingprotein-coding
Descriptioncomplement C1q subcomponent subunit Ccomplement component 1, q subcomponent, C chaincomplement component 1, q subcomponent, gamma polypeptidecomplement C1q subcomponent subunit Ccomplement component 1, q subcomponent, C chaincomplement component 1, q subcomponent, gamma polypeptide
Modification date2018051920180519
UniProtAcc

P02747

P02747

Ensembl transtripts involved in fusion geneENST00000374640, ENST00000374639, 
ENST00000374637, 
ENST00000374640, 
ENST00000374639, ENST00000374637, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 43
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/8*10)=1.90689059560852
Context

PubMed: C1QC [Title/Abstract] AND C1QC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC1QC

GO:0030853

negative regulation of granulocyte differentiation

10961870

HgeneC1QC

GO:0045650

negative regulation of macrophage differentiation

10961870

TgeneC1QC

GO:0030853

negative regulation of granulocyte differentiation

10961870

TgeneC1QC

GO:0045650

negative regulation of macrophage differentiation

10961870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE769808C1QCchr1

22970664

-C1QCchr1

22974216

-
ChiTaRS3.1BE769806C1QCchr1

22970664

-C1QCchr1

22974216

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000374640ENST00000374640C1QCchr1

22970664

-C1QCchr1

22974216

-
Frame-shiftENST00000374640ENST00000374639C1QCchr1

22970664

-C1QCchr1

22974216

-
In-frameENST00000374640ENST00000374637C1QCchr1

22970664

-C1QCchr1

22974216

-
Frame-shiftENST00000374639ENST00000374640C1QCchr1

22970664

-C1QCchr1

22974216

-
Frame-shiftENST00000374639ENST00000374639C1QCchr1

22970664

-C1QCchr1

22974216

-
In-frameENST00000374639ENST00000374637C1QCchr1

22970664

-C1QCchr1

22974216

-
Frame-shiftENST00000374637ENST00000374640C1QCchr1

22970664

-C1QCchr1

22974216

-
Frame-shiftENST00000374637ENST00000374639C1QCchr1

22970664

-C1QCchr1

22974216

-
In-frameENST00000374637ENST00000374637C1QCchr1

22970664

-C1QCchr1

22974216

-

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FusionProtFeatures for C1QC_C1QC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C1QC

P02747

C1QC

P02747

C1q associates with the proenzymes C1r and C1s to yieldC1, the first component of the serum complement system. Thecollagen-like regions of C1q interact with the Ca(2+)-dependentC1r(2)C1s(2) proenzyme complex, and efficient activation of C1takes place on interaction of the globular heads of C1q with theFc regions of IgG or IgM antibody present in immune complexes. C1q associates with the proenzymes C1r and C1s to yieldC1, the first component of the serum complement system. Thecollagen-like regions of C1q interact with the Ca(2+)-dependentC1r(2)C1s(2) proenzyme complex, and efficient activation of C1takes place on interaction of the globular heads of C1q with theFc regions of IgG or IgM antibody present in immune complexes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C1QC_C1QC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C1QC_C1QC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C1QC_C1QC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneC1QCP02747DB00002CetuximabComplement C1q subcomponent subunit Cbiotechapproved
HgeneC1QCP02747DB00051AdalimumabComplement C1q subcomponent subunit Cbiotechapproved
HgeneC1QCP02747DB00054AbciximabComplement C1q subcomponent subunit Cbiotechapproved
HgeneC1QCP02747DB00073RituximabComplement C1q subcomponent subunit Cbiotechapproved
HgeneC1QCP02747DB00005EtanerceptComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00056Gemtuzumab ozogamicinComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00072TrastuzumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00074BasiliximabComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00075MuromonabComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00078Ibritumomab tiuxetanComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00081TositumomabComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00087AlemtuzumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00095EfalizumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00108NatalizumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00110PalivizumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB00112BevacizumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
HgeneC1QCP02747DB01593ZincComplement C1q subcomponent subunit Csmall moleculeapproved|investigational
HgeneC1QCP02747DB00092AlefaceptComplement C1q subcomponent subunit Cbiotechapproved|investigational|withdrawn
TgeneC1QCP02747DB00002CetuximabComplement C1q subcomponent subunit Cbiotechapproved
TgeneC1QCP02747DB00051AdalimumabComplement C1q subcomponent subunit Cbiotechapproved
TgeneC1QCP02747DB00054AbciximabComplement C1q subcomponent subunit Cbiotechapproved
TgeneC1QCP02747DB00073RituximabComplement C1q subcomponent subunit Cbiotechapproved
TgeneC1QCP02747DB00005EtanerceptComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00056Gemtuzumab ozogamicinComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00072TrastuzumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00074BasiliximabComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00075MuromonabComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00078Ibritumomab tiuxetanComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00081TositumomabComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00087AlemtuzumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00095EfalizumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00108NatalizumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00110PalivizumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB00112BevacizumabComplement C1q subcomponent subunit Cbiotechapproved|investigational
TgeneC1QCP02747DB01593ZincComplement C1q subcomponent subunit Csmall moleculeapproved|investigational
TgeneC1QCP02747DB00092AlefaceptComplement C1q subcomponent subunit Cbiotechapproved|investigational|withdrawn

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RelatedDiseases for C1QC_C1QC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneC1QCC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneC1QCC3150902C1q DEFICIENCY1UNIPROT
TgeneC1QCC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC1QCC3150902C1q DEFICIENCY1UNIPROT